Role of photodynamic therapy in prevention of arteriovenous fistula restenosis in rabbits

Peng Guo; Yangdong Liu; Bo Tu; Qining Fu; Yu Zhao; Liangzhu Hu; Yongsheng Shi; Chao Li; Junxiu Dong

doi:10.16016/j.1000-5404.201611144

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Role of photodynamic therapy in prevention of arteriovenous fistula restenosis in rabbits

更新时间：2026-01-09

- Role of photodynamic therapy in prevention of arteriovenous fistula restenosis in rabbits
- Journal of Third Military Medical University Vol. 39, Issue 7, Pages: 635-640(2017)
- 作者机构：
- 作者简介：
- 基金信息：
  
  National Clinical Key-discipline Construction Program of China(卫办医政函[2012]649)
- DOI：10.16016/j.1000-5404.201611144
  CLC：
- Received：16 November 2016，
  
  Published：2017-07
- 稿件说明：
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Peng Guo, Yangdong Liu, Bo Tu, et al. Role of photodynamic therapy in prevention of arteriovenous fistula restenosis in rabbits[J]. Journal of Third Military Medical University, 2017, 39(7): 635-640.
DOI：

Peng Guo, Yangdong Liu, Bo Tu, et al. Role of photodynamic therapy in prevention of arteriovenous fistula restenosis in rabbits[J]. Journal of Third Military Medical University, 2017, 39(7): 635-640. DOI： 10.16016/j.1000-5404.201611144.

摘要

Abstract

Objective

To determine the effect of photodynamic therapy (PDT) on the patency rate and venous endometrial hyperplasia of arteriovenous fistula restenosis (AVF).

Methods

Atotal of 32 New Zealand rabbits of both sexes (weighing 2.0~2.5 kg) were randomly divided into control group

simple photosensitizer group

simple light group and PDT group (

=8 for each group). The AVF model was inflicted in the neck of rabbits

and corresponding treatments were given according to the groups. In 2

22 and 29 d post operation

color Doppler ultrasound examination was adopted to detect the blood flows. The intimal hyperplasia was observed and measured in 4 weeks postoperatively. The expression of proliferating cell nuclear antigen (PCNA) was detected to assess the proliferative activity by immunohistochemical staining

The apoptosis of vascular smooth muscle cells (VSMCs) was tested by terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay.

Results

The AVF blood flow was significantly stronger in the PDT group than the other 3 groups in 15

22 and 29 d postoperatively (

0.05). And the hyperplasia thickness was obviously milder in the former group than the latter groups in 4 weeks (

0.05). The PDT group had remarkably weaker expression of PCNA (

0.05) and higher apoptotic rate of VSMCs when compared with the 3 groups (

0.05).

Conclusion

PDT efficiently promotes the apoptosis of VSMCs

inhibits the venous endometrial hyperplasia

and thus enhances the blood flow of AVF.

关键词

Keywords

references

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