Clinically relevant risk factors for acute kidney injury after pediatric congenital heart surgery

Jingwen Zhang; Jia You; Qin Chen; Rui Xiao; Hong Li; Zhiyong Du; He Huang; Tiande Yang

doi:10.16016/j.1000-5404.201611112

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Clinically relevant risk factors for acute kidney injury after pediatric congenital heart surgery

更新时间：2026-01-09

- Clinically relevant risk factors for acute kidney injury after pediatric congenital heart surgery
- Journal of Third Military Medical University Vol. 39, Issue 9, Pages: 929-934(2017)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201611112
  CLC：
- Received：12 November 2016，
  
  Published：15 May 2017
- 稿件说明：
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Jingwen Zhang, Jia You, Qin Chen, et al. Clinically relevant risk factors for acute kidney injury after pediatric congenital heart surgery[J]. Journal of Third Military Medical University, 2017, 39(9): 929-934.
DOI：

Jingwen Zhang, Jia You, Qin Chen, et al. Clinically relevant risk factors for acute kidney injury after pediatric congenital heart surgery[J]. Journal of Third Military Medical University, 2017, 39(9): 929-934. DOI： 10.16016/j.1000-5404.201611112.

摘要

Abstract

Objective

To investigate the risk factors for acute kidney injury (AKI) in children aged < 4 years old following congenital heart surgery.

Methods

Clinical data of pediatric patients (younger than 4 years old) undergoing congenital heart surgery in our hospital from April 2015 to April 2016 were collected. The modified criteria of pediatric risk

injury

and failure

and loss

and end-stage kidney disease (pRIFLE) were used to detect the incidence of AKI. The differences between the children with AKI and without were analyzed. Multivariate logistic regression analysis was employed to study the risk factors of AKI following congenital heart surgery.

Results

Of the 298 patients subjected

there were 152 boys and 146 girls. The incidence of AKI accounted for 35.91% (107 cases)

and 82 children (27.52%) attained at risk stage

16 (5.37%) at injury stage

and 9 (3.02%) at failure stage. Compared with the children without AKI

those with AKI had younger age

shorter height

lower weight and lower Scr pre-operatively

but more complications of preoperative cyanosis and comorbidities

higher class in American Society of Anesthesiologists (ASA) physical status classification system

longer duration of surgery

cardiac pulmonary bypass (CPB) time

and aortic clamping time (ACT). They also had higher levels of urea

uric acid

serum creatinine (Scr)

cystatin-C and retinol-binding protein

but lower estimated creatinine clearance (eCCl)

longer hospital stay and higher mortality after surgery. Logistic regression analysis showed that younger than 1 year old

cynosis

lower pre-operative Scr

and longer duration of surgery were independent risk factors for AKI.

Conclusion

Younger than 1 year old

complication of cynosis

lower pre-operative Scr

and longer duration of surgery significantly increase the incidence of AKI after congenital heart surgery.

关键词

Keywords

references

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