Effects of different absorption enhancers on intestinal absorption of montelukast sodium in rabbits

Yaqi Cao; Zhangyang Wang; Qing Dai

doi:10.16016/j.1000-5404.201611102

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Effects of different absorption enhancers on intestinal absorption of montelukast sodium in rabbits

更新时间：2026-01-09

- Effects of different absorption enhancers on intestinal absorption of montelukast sodium in rabbits
- Journal of Third Military Medical University Vol. 39, Issue 9, Pages: 897-903(2017)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201611102
  CLC：
- Received：28 November 2016，
  
  Published：15 May 2017
- 稿件说明：
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Yaqi Cao, Zhangyang Wang, Qing Dai. Effects of different absorption enhancers on intestinal absorption of montelukast sodium in rabbits[J]. Journal of Third Military Medical University, 2017, 39(9): 897-903.
DOI：

Yaqi Cao, Zhangyang Wang, Qing Dai. Effects of different absorption enhancers on intestinal absorption of montelukast sodium in rabbits[J]. Journal of Third Military Medical University, 2017, 39(9): 897-903. DOI： 10.16016/j.1000-5404.201611102.

摘要

Abstract

Objective

To investigate the rectal absorption profile of montelukast sodium in the rabbits and determine the effects of different absorption enhancers on the absorption.

Methods

A method of high-performance liquid chromatography (HPLC) was established to detect the blood concentrations of montelukast sodium in the rabbits. The blood concentration was measured in the rabbits after rectal administration in the presences of different absorption enhancers

including Tween-80

sodium caprate

sodium cholate

laurocapram

laurate sodium

L-arginine

chlorpromazine hydrochloride and EDTA-2Na. With he blood concentration after venous administration as control

the rectal absorption profile of montelukast sodium and the effects of different absorption enhancers were evaluated.

Results

Montelukast sodium was minimally absorbed in the rectum. All the absorption enhancers exerted promoting effects on its intestinal absorption in a concentration-dependent manner. The absorption enhancing effects of the absorption enhancers were as following order

10% Tween-80

1% sodium caprate

0.2% sodium cholate

4% laurocapram

3% laurate sodium

1.5% L-arginine (

0.05). The effect of 2% chlorpromazine hydrochloride and 1%EDTA-2Na was similar

with mild effect.

Conclusion

The rectum is not a favorable absorption site for montelukast sodium. Absorption enhancers can promote its rectal absorption. 10% Tween-80 has the best enhancing effect on its absorption.

关键词

Keywords

references

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