Changes of myelinated nerve fibers in hippocampus of APP/PS1 transgenic mice with early symptoms of Alzheimer's disease: a stereological study

Zhenhua Zhao; Fenglei Chao; Lei Zhang; Yi Zhang; Chunni Zhou; Lin Jiang; Qian Xiao; Yanmin Luo; Wei Huang; Changqiong Li; Wei Tang; Tao Li; Yong Tang

doi:10.16016/j.1000-5404.201610106

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Changes of myelinated nerve fibers in hippocampus of APP/PS1 transgenic mice with early symptoms of Alzheimer's disease: a stereological study

更新时间：2026-01-09

- Changes of myelinated nerve fibers in hippocampus of APP/PS1 transgenic mice with early symptoms of Alzheimer's disease: a stereological study
- Journal of Third Military Medical University Vol. 39, Issue 8, Pages: 760-766(2017)
- 作者机构：
- 作者简介：
- 基金信息：
  
  the General Program of National Natural Science Foundation of China(81470057);the General Program of National Natural Science Foundation of China(81671259);the General Program of National Natural Science Foundation of China(81501101);the Project of the First Batch of "100 Academic and Discipline Talented Leaders" of Chongqing(2012);the Foundation of Excellent Doctoral Dissertation of Chongqing Medical University (2016);the Innovative Project for Graduate Students of Chongqing (2016)
- DOI：10.16016/j.1000-5404.201610106
  CLC：
- Published：2017-04
- 稿件说明：
移动端阅览
Zhenhua Zhao, Fenglei Chao, Lei Zhang, et al. Changes of myelinated nerve fibers in hippocampus of APP/PS1 transgenic mice with early symptoms of Alzheimer's disease: a stereological study[J]. Journal of Third Military Medical University, 2017, 39(8): 760-766.
DOI：

Zhenhua Zhao, Fenglei Chao, Lei Zhang, et al. Changes of myelinated nerve fibers in hippocampus of APP/PS1 transgenic mice with early symptoms of Alzheimer's disease: a stereological study[J]. Journal of Third Military Medical University, 2017, 39(8): 760-766. DOI： 10.16016/j.1000-5404.201610106.

摘要

Abstract

Objective

To investigate the changes of myelinated fibers and myelin sheaths in the hippocampus of APP/PS1 transgenetic mice with early onset of symptoms of Alzheimer's Disease (AD).

Methods

The spatial learning and memory abilities of 10-month-old APP/PS1 transgenic mice and wild-type mice were evaluated with Morris water maze test. The volume of the hippocampus

CA1 and the dentate gyrus (DG)

and the length of the myelinated nerve fibers and the total volume of the myelinated nerve fibers and myelin sheathes in the CA1 region and the DG were determined using an unbiased stereological method coupled with electron microscope technique.

Results

Compared with the wild-type mice

the transgenic mice showed a significantly increas

ed mean escape latency (

0.05) and a decreased percentage of time staying in the target quadrant (

0.01)

but with comparable frequencies of crossing the platform location (

0.05). The volumes of the hippocampus

CA1 region and the DG were significantly decreased in the transgenic mice compared with those in the wild-type mice (

0.01

0.05). The total length of the myelinated fibers in the hippocampal CA1 region and DG did not differ significantly between the transgenic and wild-type mice (

0.05)

but the total volumes of the myelinated fibers and myelin sheathes in the hippocampal CA1 region and DG were significantly smaller in the transgenic mice (

0.05

0.01).

Conclusion

Demyelization occurs in the hippocampal CA1 region and DG of 10-month-old APP/PS1 transgenic mice that show early AD symptoms

and these changes might contribute as one of the structural basis to memory and learning deficits in the mice.

关键词

Keywords

references

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