Efficacy of surface ablation with continuous versus pulsed high-intensity focused ultrasound in isolated bovine liver

Jing Wen; Jianzhong Zou; Qi Wang; Dazhao Ma; Xiaoya Ding

doi:10.16016/j.1000-5404.201610064

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Efficacy of surface ablation with continuous versus pulsed high-intensity focused ultrasound in isolated bovine liver

更新时间：2026-01-09

- Efficacy of surface ablation with continuous versus pulsed high-intensity focused ultrasound in isolated bovine liver
- Journal of Third Military Medical University Vol. 39, Issue 8, Pages: 749-754(2017)
- 作者机构：
- 作者简介：
- 基金信息：
  
  the National Basic Research and Development Program(973计划);the National Key Basic Research Development Program(2011CB707900);the Special Project for Major Scientific Equipment and Instrument Development of National Natural Science Foundation of China(81127901);the General Program of National Natural Science Foundation of China(11574039);the General Program of National Natural Science Foundation of China(11274404)
- DOI：10.16016/j.1000-5404.201610064
  CLC：
- Received：12 October 2016，
  
  Published：30 April 2017
- 稿件说明：
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Jing Wen, Jianzhong Zou, Qi Wang, et al. Efficacy of surface ablation with continuous versus pulsed high-intensity focused ultrasound in isolated bovine liver[J]. Journal of Third Military Medical University, 2017, 39(8): 749-754.
DOI：

Jing Wen, Jianzhong Zou, Qi Wang, et al. Efficacy of surface ablation with continuous versus pulsed high-intensity focused ultrasound in isolated bovine liver[J]. Journal of Third Military Medical University, 2017, 39(8): 749-754. DOI： 10.16016/j.1000-5404.201610064.

摘要

Abstract

Objective

To compare the effect of surface ablation with continuous high-intensity focused ultrasound (CHIFU) and pulsed high-intensity focused ultrasound (PHIFU) and investigate the optimization of surface ablation mode with HIFU.

Methods

Forty samples of fresh bovine liver tissues were divided into group A (

=30) and group B (

=10) for surface ablation with PHIFU and CHIFU

respectively. According to the duty cycles

the samples in group A were divided into 3 equal subgroups with duty cycles of 10% (group A1)

30% (group A2)

and 50% (group A3). With ultrasonographic guidance

the target areas in the liver tissues were irradiated with PHIFU and CHIFU for surface ablation

and the temperature changes in the geometric center of the target area were recorded. After ablation

tissue damages in the peripheral area and the areas within and outside the target area were observed

the energy efficiency factor (EEF) was calculated

and the temperature-time curve was analyzed.

Results

Compared with that in group B

the EEF in the 3 subgroups in group A all reduced significantly (

0.05)

and the reduction became more prominent as the duty cycles increased. Thermal damage outside the target area was observed only in group B. In each group

confined lesions were formed following the ablation

and the irradiated areas showed liquid necrosis in subgroup A1 and coagulation necrosis in the other groups. Within the target area of ablation

the tissue damage was intensified as the duty cycle increased

and the peak temperature in the center of the target area exceeded 60 ℃ in all the groups only with the exception of group A1.

Conclusion

Compared with CHIFU surface ablation

PHIFU surface ablation has a greater ablation efficiency and reduces tissue damage outside the target area. In PHIFU peripheral ablation

the temperature and tissue damage of the non-irradiated internal tissue within the target area can be controlled by adjusting the duty cycles.

关键词

Keywords

references

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