HSF1 expression in cervical carcinoma and its correlation with clinical pathological characteristics and prognosis

Shaomin Yu; Min Cheng; Liangsi Hou; Wenjun Zhang; Bin Liu; hu Hua Ling

doi:10.16016/j.1000-5404.201610023

您当前的位置：

首页 >

文章列表页 >

HSF1 expression in cervical carcinoma and its correlation with clinical pathological characteristics and prognosis

更新时间：2026-01-09

- HSF1 expression in cervical carcinoma and its correlation with clinical pathological characteristics and prognosis
- Journal of Third Military Medical University Vol. 39, Issue 6, Pages: 560-563(2017)
- 作者机构：
  
  1.400016 重庆，重庆医科大学附属第一医院妇产科
  2.400016 重庆，重庆医科大学基础医学院病理学教研室
- 作者简介：
- 基金信息：
  
  the Key Project of Chongqing Science and Technology Commission(CSTC2014yykfB10011);the National Science and Technology Welfare Plan of China(2013GS500101-18)
- DOI：10.16016/j.1000-5404.201610023
  CLC： R341; R730.23; R737.33
- Received：07 October 2016，
  
  Revised：2016-12-14，
  
  Published：2017-06
- 稿件说明：
移动端阅览
Shaomin Yu, Min Cheng, Liangsi Hou, et al. HSF1 expression in cervical carcinoma and its correlation with clinical pathological characteristics and prognosis[J]. Journal of Third Military Medical University, 2017, 39(6): 560-563.
DOI：

Shaomin Yu, Min Cheng, Liangsi Hou, et al. HSF1 expression in cervical carcinoma and its correlation with clinical pathological characteristics and prognosis[J]. Journal of Third Military Medical University, 2017, 39(6): 560-563. DOI： 10.16016/j.1000-5404.201610023.

摘要

目的

分析宫颈癌组织中热休克因子1(heat-shock factor 1，HSF1) 表达与临床病理特征及生存的相关性。

方法

收集2009年11月至2013年12月于重庆医科大学附属第一医院妇科直接行手术治疗的FIGO分期为ⅠA~ⅡA期的宫颈癌病例，检测并分析癌组织中HSF1的表达与临床病理特征及无进展生存时间 (progress free survival

PFS) 的相关性。

结果

癌组织中HSF1表达强度与癌细胞肌层浸润深度呈显著正相关 (

=0.02)；在高级别病变、脉管癌栓阳性及淋巴结阳性患者组织中HSF1表达高于低级别病变、无脉管癌栓及淋巴结转移患者，但差异无统计学意义 (

=0.45、0.80、0.13)。HSF1表达的高、低对早期宫颈癌的PFS没有显著影响 (

=0.33)，但癌症基因组图谱 (the Cancer Genome Atlas，TCGA) 数据库中320例宫颈癌患者的基因数据分析显示：HSF1基因表达越强，患者的预后越差 (

=0.02)。

结论

癌组织中HSF1高强度表达与宫颈癌进展程度直接相关，并可能直接影响生存。

Abstract

Objective

To assess the correlation of heat shock factor 1 (HSF1) expression with clinical pathological characteristics and prognosis in the patients with cervical carcinoma.

Methods

A total of 119 patients with stage ⅠA-ⅡA cervical carcinoma

who were diagnosed in our hospital during November 2009 and December 2013 and received primary surgery

were enrolled. Their clinical data and tissue samples were collected. HSF1 expression was detected through immunohistochemistry

and its prognostic significance was analyzed retrospectively.

Results

High HSFl expression was significantly correlated with the deep stromal invasion (

=0.02). Similarly

higher HSF1 expression was also found in higher grade carcinoma samples (

=0.45)

and in the patients with lymph vascular involvement (

=0.13) and lymph node metastasis (

=0.80)

though without statistical significance. Although the expression of HSFl did not demonstrate prognostic significance to the progression-free survival (

=0.33) in the 119 patients with early stage cervical carcinoma

the data of 320 cervical carcinoma patients in the Cancer Genome Atlas (TCGA) showed the correlation of high HSFl expression with poor prognosis (

=0.02).

Conclusion

High HSF1 expression may reflect the invasiveness of cervical carcinoma

which probably predicts the poor survival.

关键词

Keywords

references

Salvatici M, Achilarre M T, Sandri M T, et al. Squamous cell carcinoma antigen (SCC-Ag) during follow-up of cervical cancer patients: Role in the early diagnosis of recurrence[J]. Gynecol Oncol, 2016, 142(1): 115-119. DOI:10.1016/j.ygyno.2016.04.029

Scherz-Shouval R, Santagata S, Mendillo M L, et al. The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy[J]. Cell, 2014, 158(3): 564-578. DOI:10.1016/j.cell.2014.05.045

Fang F, Chang R, Yang L. Heat shock factor 1 promotes invasion and metastasis of hepatocellular carcinoma in vitro and in vivo[J]. Cancer, 2012, 118(7): 1782-1794. DOI:10.1002/cncr.26482

冯子童, 田辉, 岳韦名, 等.转录因子HSF1在食管鳞状细胞癌组织中的表达及其临床意义[J].中国肿瘤生物治疗杂志, 2015, 22(4): 489-494. DOI:10.3872/j.issn.1007-385X.2015.04.014

Feng Z T, Tian H, Yue W M, et al. Expression and clinical significance of transcription factor hsf1 in human esophageal squamous carcinoma[J]. Chinese Journal of Cancer Bio therapy, 2015, 22(4): 489-494. DOI:10.3872/j.issn.1007-385X.2015.04.014

Hoang A T, Huang J, Rudra-Ganguly N, et al. A novel association between the human heat shock transcription factor 1 (HSF1) and prostate adenocarcinoma[J]. Am J Pathol, 2000, 156(3): 857-864. DOI:10.1016/S0002-9440(10)64954-1

Dudeja V, Chugh R K, Sangwan V, et al. Prosurvival role of heat shock factor 1 in the pathogenesis of pancreatobiliary tumors[J]. Am J Physiol Gastrointest Liver Physiol, 2011, 300(6): G948-G955. DOI:10.1152/ajpgi.00346.2010

Santagata S, Hu R, Lin N U, et al. High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer[J]. Proc Nat Acad Sci U S A, 2011, 108(45): 18378-18383. DOI:10.1073/pnas

Jin X, Moskophidis D, Mivechi N F. Heat shock transcription factor 1 is a key determinant of HCC development by regulating hepatic steatosis and metabolic syndrome[J]. Cell Metab, 2011, 14(1): 91-103. DOI:10.1016/j.cmet.2011.03.025

Budwit-Novotny D A, McCarty K S, Cox E B, et al. Immunohistochemical analyses of estrogen receptor in endometrial adenocarcinoma using a monoclonal antibody[J]. Cancer Res, 1986, 46(10): 5419-5425.

Izu H, Inouye S, Fujimoto M, et al. Heat shock transcription factor 1 is involved in quality-control mechanisms in male germ cells[J]. Biol Reprod, 2004, 70(1): 18-24. DOI:10.1095/biolreprod.103.020065

Page T J, Sikder D, Yang L, et al. Genome-wide analysis of human HSF1 signaling reveals a transcriptional program linked to cellular adaptation and survival[J]. Mol Biosyst, 2006, 2(12): 627-639. DOI:10.1039/b606129j

Das S, Bhattacharyya N P. Heat shock factor 1 regulates hsa-miR-432 expression in human cervical cancer cell line[J]. Biochem Biophys Res Commun, 2014, 453(3): 461-466. DOI:10.1016/j.bbrc.2014.09.100

Rossi A, Ciafrè S, Balsamo M, et al. Targeting the heat shock factor 1 by RNA interference: a potent tool to enhance hyperthermochemotherapy efficacy in cervical cancer[J]. Cancer Res, 2006, 66(15): 7678-7685. DOI:10.1158/0008-5472

潘秀玉, 艾文霞, 熊慧华, 等. ⅠA~ⅡB期宫颈癌盆腔淋巴结转移高危因素的临床分析[J].华中科技大学学报:医学版, 2011, 40(6): 686-691, 696. DOI:10.3870/j.issn.1672-0741.2011.06.013

Pan X Y, Ai W X, Xiong H H, et al. Analysis of risk factors of Ⅰa-Ⅱ b cervical carcinoma with pelvic lymphnode metastasis[J]. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong, 2011, 40(6): 686-691, 696. DOI:10.3870/j.issn.1672-0741.2011.06.013

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Difference of γ-tubulin and aurora-A expression in human cervical cancer and H8 cells

Expression and significance of pro-apoptotic factors and anti-apoptotic factors in cervical intraepithelial neoplasia and cervical carcinoma

Related Author

巫静娴

赵涌

刘晓云

熊正爱

郑洪

Related Institution

No data

⁰