Effect of Honghua Injection on distribution of levofloxacin in uterine tissue of pelvic inflammatory rats

Lingxi Kong; Yan Huang; Feng Qiu; Haixia He; Cheng Luo

doi:10.16016/j.1000-5404.201609061

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Effect of Honghua Injection on distribution of levofloxacin in uterine tissue of pelvic inflammatory rats

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- Effect of Honghua Injection on distribution of levofloxacin in uterine tissue of pelvic inflammatory rats
- J Third Mil Med Univ Vol. 39, Issue 4, Pages: 361-366(2017)
- 作者机构：
- 作者简介：
- 基金信息：
  
  the Medical Research Program of Chongqing Health and Family Planning Commission(20142188)
- DOI：10.16016/j.1000-5404.201609061
  CLC：
- Received：08 September 2016，
  
  Published：28 February 2017
- 稿件说明：
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Lingxi Kong, Yan Huang, Feng Qiu, et al. Effect of Honghua Injection on distribution of levofloxacin in uterine tissue of pelvic inflammatory rats[J]. J Third Mil Med Univ, 2017, 39(4): 361-366.
DOI：

Lingxi Kong, Yan Huang, Feng Qiu, et al. Effect of Honghua Injection on distribution of levofloxacin in uterine tissue of pelvic inflammatory rats[J]. J Third Mil Med Univ, 2017, 39(4): 361-366. DOI： 10.16016/j.1000-5404.201609061.

摘要

Abstract

Objective

To study the effect of Honghua Injection on the distribution of levofloxacin (LVFX) in the uterine tissue of pelvic inflammatory rat model.

Method

Ninety-six female rats with bacterial pelvic inflammation

were randomly divided into (

=48 per group) experimental group (combined treatment of Honghua and LVFX) and control group (only LVFX). Rats in experimental group were intramuscularly injected with Honghua Injection (0.8 mL/kg) for 3 consecutive days

and those in the control group were given the same volume of normal saline. On the day 4

all the rats were orally administered with LVFX(80 mg/kg). Six rats of each group were sacrificed at each time point of 0.25

0.5

1.5

8 and 12 h after Honghua Injection for collecting the plasma and uterine samples. Concentrations of LVFX in the plasma and uterine homogenous tissues were detected by high performance liquid chromatography (HPLC)

and pharmacokinetic parameters were calculated with DAS 2 software.

Results

Concentration-time curves of LVFX of the both groups fit the two-compartment model. The values of main pharmacokinetic parameters in plasma and uterine tissue of experiment and control groups were listed as follows:

max

were 14.28±0.84 and 14.45±1.93 μg/mL for plasma

15.85±1.32 and 12.65±1.01 μg/mL for uterine;

max

were 1.42±0.20 and 1.50±0.01 h for plasma

1.25±0.27 and 1.17±0.26 h for uterine;

1/2β

were 7.69±2.61 and 7.32±2.80 h for plasma

7.95±5.29 and 9.16±3.00 h for uterine;Clearance (CL) were 1.25±0.18 and 1.35±0.25 L/(kg·h) for plasma

1.08±0.08 and 1.47±0.16 L/(kg·h) for uterine;Area under curve (AUC)

were 55.13±5.42 and 51.73±5.27 μg·h/mL for plasma

63.69±3.95 and 48.95±4.11 μg·h/mL for uterine. Moreover

the differences of parameters

max

CL and AUC

in the uterine tissue were statistically significant between the 2 groups (

0.01).

Conclusion

Honghua Injection can obviously increase the concentration of LVFX in the uterine tissue of pelvic inflammatory rats.

关键词

Keywords

references

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