Association of single nucleotide polymorphisms of suppressor of cytokine signaling 1 gene with pulmonary tuberculosis in Liangshan Yi ethnic minority

Chao Wang; Wenbin Jiang; Yanxia Xue; Jiao Wang; Jie Luo; Huan Xu; Cheng Yang; Ming Chen; Shaoli Deng

doi:10.16016/j.1000-5404.201608118

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Association of single nucleotide polymorphisms of suppressor of cytokine signaling 1 gene with pulmonary tuberculosis in Liangshan Yi ethnic minority

更新时间：2026-01-09

- Association of single nucleotide polymorphisms of suppressor of cytokine signaling 1 gene with pulmonary tuberculosis in Liangshan Yi ethnic minority
- Journal of Third Military Medical University Vol. 39, Issue 3, Pages: 291-295(2017)
- 作者机构：
- 作者简介：
- 基金信息：
  
  Supported by the General Program of National Natural Science Foundation of China(81371760);Major Project of National Infectious Diseases of China(2013ZX10003006-003-002)
- DOI：10.16016/j.1000-5404.201608118
  CLC：
- Received：22 August 2016，
  
  Published：15 January 2017
- 稿件说明：
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Chao Wang, Wenbin Jiang, Yanxia Xue, et al. Association of single nucleotide polymorphisms of suppressor of cytokine signaling 1 gene with pulmonary tuberculosis in Liangshan Yi ethnic minority[J]. Journal of Third Military Medical University, 2017, 39(3): 291-295.
DOI：

Chao Wang, Wenbin Jiang, Yanxia Xue, et al. Association of single nucleotide polymorphisms of suppressor of cytokine signaling 1 gene with pulmonary tuberculosis in Liangshan Yi ethnic minority[J]. Journal of Third Military Medical University, 2017, 39(3): 291-295. DOI： 10.16016/j.1000-5404.201608118.

摘要

Abstract

Objective

To investigate the genetic association of 2 tag single nucleotide polymorphisms (tagSNP) of suppressor of cytokine signaling 1 (SOCS1) gene

rs243327 and rs33932899 with the risk of pulmonary tuberculosis in the people of Yi ethnic minority living in Liangshan

Sichuan Province.

Methods

A total of 188 patients of Yi nationality with pulmonary tuberculosis and 229 Yi healthy people were enrolled in this study. Their blood samples were collected during March 2015 and June 2016 in Liangshan Yi Autonomous Prefecture. Two tagSNP polymorphisms were analyzed by gene sequencing

and the genotype and allele frequency between pulmonary tuberculosis group and healthy control group were determined by Chi square test.

Results

Both rs243327 and rs3393289 showed no deviation from Hardy-Weinberg equilibrium (HWE) in either the case or the control. The results showed that there was a significant correlation between rs243327 polymorphism and pulmonary tuberculosis

and the frequency of CC genotype was higher in pulmonary tuberculosis patients than healthy control (CC

CT:

=1.611

95%

: 1.058~2.453

=0.026; CC

CT+TT:

=1.651

95%

: 1.107~2.461

=0.014)

indicating that CC carriers of rs243327 may increase the risk of pulmonary tuberculosis in Yi people

and had genetic susceptibility of tuberculosis. Meanwhile

the frequency of C allele was also higher in the patients than the healthy control (C

=1.516

95%

: 1.089~2.109

=0.013)

and C allele might be susceptible allele for pulmonary tuberculosis. While there was no significant correlation between rs33932899 polymorphism and pulmonary tuberculosis (GG

CG:

=1.148

95%

: 0.762~1.731

=0.436; GG

CC:

=2.184

95%

: 0.874~5.454

=0.088; GG

CG+CC:

=1.229

95%

: 0.875~1.928

=0.193;G

=1.290

95%

: 0.932~1.785

=0.124). This indicated that rs33932899 was not associated with the susceptibility of pulmonary tuberculosis.

Conclusion

rs243327 polymorphism may be associated with the occurrence and development of pulmonary tuberculosis in the Liangshan Yi population.

关键词

Keywords

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