辛伐他汀对血管升压素诱导大鼠心脏成纤维细胞增殖的影响

徐琳; 赵连友; 范延红; 田建伟; 杨学东; 张海涛; 陈永清; 彭育红

doi:10.16016/j.1000-5404.2001.12.029

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辛伐他汀对血管升压素诱导大鼠心脏成纤维细胞增殖的影响

更新时间：2026-01-09

- 辛伐他汀对血管升压素诱导大鼠心脏成纤维细胞增殖的影响
- Journal of Army Medical University Vol. 23, Issue 12, (2001)
- 作者机构：
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- DOI：10.16016/j.1000-5404.2001.12.029
  CLC： R965
- Online First：30 December 2001，
  
  Published：2001
- 稿件说明：
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徐琳,赵连友,范延红,田建伟,杨学东,张海涛,陈永清,彭育红,辛伐他汀对血管升压素诱导大鼠心脏成纤维细胞增殖的影响[J].陆军军医大学学报(原第三军医大学学报),2001,23(12):0-.

徐琳, 赵连友, 范延红, et al. 辛伐他汀对血管升压素诱导大鼠心脏成纤维细胞增殖的影响[J]. Journal of Army Medical University, 2001, 23(12).
徐琳,赵连友,范延红,田建伟,杨学东,张海涛,陈永清,彭育红,辛伐他汀对血管升压素诱导大鼠心脏成纤维细胞增殖的影响[J].陆军军医大学学报(原第三军医大学学报),2001,23(12):0-. DOI：10.16016/j.1000-5404.2001.12.029

徐琳, 赵连友, 范延红, et al. 辛伐他汀对血管升压素诱导大鼠心脏成纤维细胞增殖的影响[J]. Journal of Army Medical University, 2001, 23(12). DOI： 10.16016/j.1000-5404.2001.12.029.

摘要

目的　探讨辛伐他汀 (Simvastatin

Sim)对血管升压素 (AVP)诱导的新生SD大鼠心脏成纤维细胞 (CFs)增殖的影响

为防治高血压心肌纤维化提供理论依据。方法　采用胰酶消化、差速贴壁法培养新生SD大鼠CFs

以3H 胸腺嘧啶核苷 (3H TdR)掺入法测定DNA合成、四氮唑盐 (MTT)比色法测定细胞数目

分别观察不同浓度Sim对AVP诱导CFs增殖的作用及甲羟戊酸 (Meval onate

MVA)干预的影响。结果　①CFs(2 0 0个细胞 )的3H TdR掺入率随着Sim干预浓度的增加而降低

其中 1 0 - 6mol/LSim和 1 0 - 5mol/LSim组的3H TdR掺入率分别为 (1 1 75± 2 0 2 6 6 )、(771± 1 6 4 86 )cpm

明显低于对照组 (1 95 5± 3 72 45 )cpm(P 0 0 1 ) ;②MTT比色法A490 值随Sim浓度的增加而降低

其中 1 0 - 6、1 0 - 5mol/LSim组的A490 值分别为 0 2 1 5± 0 0 4 1和 0 1 6 3± 0 0 1 8

均较对照组A490值 0 3 93± 0 0 4 8显著降低 (P 0 0 1 ) ;③ 1 0 - 5mol/LSim +1 0 - 3mol/LMVA组的3H TdR掺入率、MTT比色法A490 值分别为 (1 995±3 5 3 83 )cpm和 0 41 8± 0 0 4 5

均显著高于 1 0 - 5mol/LSim组 (P 0 0 1 )。结论　辛伐他汀可抑制AVP诱导的CFsDNA的合成和细胞数目增加

提示Sim可抑制CFs增殖

其机制可能通过甲?

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