肌成纤维细胞凋亡与肥厚性瘢痕消退的关系

汪琴; 吴宗耀

doi:10.16016/j.1000-5404.1999.03.016

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肌成纤维细胞凋亡与肥厚性瘢痕消退的关系

更新时间：2026-01-09

- 肌成纤维细胞凋亡与肥厚性瘢痕消退的关系
- Journal of Army Medical University Vol. 21, Issue 3, (1999)
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- DOI：10.16016/j.1000-5404.1999.03.016
  CLC： R619.6
- Online First：30 March 1999，
  
  Published：1999
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汪琴,吴宗耀,肌成纤维细胞凋亡与肥厚性瘢痕消退的关系[J].陆军军医大学学报(原第三军医大学学报),1999,21(03):0-.

汪琴, 吴宗耀. 肌成纤维细胞凋亡与肥厚性瘢痕消退的关系[J]. Journal of Army Medical University, 1999, 21(3).
汪琴,吴宗耀,肌成纤维细胞凋亡与肥厚性瘢痕消退的关系[J].陆军军医大学学报(原第三军医大学学报),1999,21(03):0-. DOI：10.16016/j.1000-5404.1999.03.016

汪琴, 吴宗耀. 肌成纤维细胞凋亡与肥厚性瘢痕消退的关系[J]. Journal of Army Medical University, 1999, 21(3). DOI： 10.16016/j.1000-5404.1999.03.016.

摘要

目的：探讨肥厚性瘢痕消退与细胞凋亡的关系。方法：应用光镜、电镜、ＴＵＮＥＬ技术和免疫组织化学染色对６１例肥厚性瘢痕、２０例非肥厚性瘢痕和８例正常皮肤进行细胞凋亡，α－ＳＭ－ａｃｔｉｎ表达的分析。结果：肥厚性瘢痕中大多数肌成纤维细胞表达α－ＳＭａｃｔｉｎ；肥厚性瘢痕中存在细胞凋亡现象，肥厚性瘢痕消退过程中成纤维细胞数的减少与肌成纤维细胞凋亡增加相一致。结论：细胞凋亡现象是肥厚性瘢痕退化过程中肌成纤维细胞减少的主要原因。促进肌成纤维细胞凋亡可能是肥厚性瘢痕治疗的新途径

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