Influence of CTLA4Ig combined with rapamycin on the survival of renal allografts in rats

HUANG Chibing; et al

doi:10.13406/j.cnki.cyxb.2005.05.013

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Influence of CTLA4Ig combined with rapamycin on the survival of renal allografts in rats

更新时间：2024-01-17

- Influence of CTLA4Ig combined with rapamycin on the survival of renal allografts in rats
- Journal of Chongqing Medical University Issue 5, (2005)
- 作者机构：
  
  1. 第三军医大学附属新桥医院泌尿外科肾移植中心
  2. 第三军医大学附属新桥医院泌尿外科肾移植中心,重庆,400037
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.05.013
  CLC： R699.2
- Published：2005，
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[1]黄赤兵,张银甫,范明齐,王平贤,冯嘉渝,肖亚,贾维胜,方针强.共刺激阻断剂与雷帕霉素联合应用对移植肾存活的影响[J].重庆医科大学学报,2005(05):50-52.

HUANG Chibing, et al. Influence of CTLA4Ig combined with rapamycin on the survival of renal allografts in rats. [J]. Journal of Chongqing Medical University (5).(2005)
[1]黄赤兵,张银甫,范明齐,王平贤,冯嘉渝,肖亚,贾维胜,方针强.共刺激阻断剂与雷帕霉素联合应用对移植肾存活的影响[J].重庆医科大学学报,2005(05):50-52. DOI： 10.13406/j.cnki.cyxb.2005.05.013.

HUANG Chibing, et al. Influence of CTLA4Ig combined with rapamycin on the survival of renal allografts in rats. [J]. Journal of Chongqing Medical University (5).(2005) DOI： 10.13406/j.cnki.cyxb.2005.05.013.

摘要

目的:探讨共刺激阻断剂CTLA4Ig与雷帕霉素（Rapamycin

RPM）联合应用对大鼠移植肾存活的影响。方法:肾移植大鼠分为对照组、CTLA4Ig组、RPM组和CTLA4Ig+RPM组

观察术后血肌酐和移植肾病理改变、移植肾存活时间。结果:与对照组相比

CTLA4Ig组、RPM组、CTLA4Ig+RPM组移植肾存活时间均显著延长（P<0.01）

其中

CTLA4Ig+RPM组移植肾存活时间最长（76.5±17.1d）

术后15天、30天该组血肌酐浓度最低;术后30天

仍然存活的CTLA4Ig组移植肾显示较多淋巴细胞浸润

CTLA4Ig+RPM组移植肾显示很少淋巴细胞浸润。结论:共刺激阻断剂与雷帕霉素联合应用可有效抑制排斥反应

显著延长大鼠移植肾存活时间。

Abstract

Objective:To study the influence of Costimulatory Blockade CTLA4Ig combined with rapamycin(RPM)on the survival of renal allografts in rats.Methods:BN→Lewis rat kidney transplantation was performed.The recipients were grouped into group1(control)

group2(CTLA4Ig)

group3(rapamycin

RPM) and group4(CTLA4Ig+RPM).The survival of renal allografts

serum creatinine of the recipients and the pathological changes of the allografts were observed.Results:Significantly prolonged allografts survival time was seen in group 2

3 and 4 compared with control

with the longest in group 4.The lowest serum creatinine and fewest lymphocytes infiltrating grafts were also seen in group4.Conclusion:Combined use of CTLA4Ig and rapamycin(RPM)may suppress renal allograft rejection effectively and promote further prolongation of the survival of renal allografts.

关键词

共刺激阻断剂雷帕霉素肾移植

Keywords

Costimulatory Blockaderapamycinkidney transplantation

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第三军医大学附属新桥医院泌尿外科

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