Correlation of estrogen receptor expression to activity of cell proliferation and chincopathology in brain tumors

WANG Shunhe; et al

doi:10.13406/j.cnki.cyxb.2005.05.012

您当前的位置：

首页 >

文章列表页 >

Correlation of estrogen receptor expression to activity of cell proliferation and chincopathology in brain tumors

更新时间：2024-01-17

- Correlation of estrogen receptor expression to activity of cell proliferation and chincopathology in brain tumors
- Journal of Chongqing Medical University Issue 5, (2005)
- 作者机构：
  
  1. 重庆医科大学基础医学院病理教研室
  2. 重庆医科大学基础医学院病理教研室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.05.012
  CLC： R739.4
- Published：2005，
扫描看全文
[1]王顺和,王光辉,李园园,杨慧敏.ER在脑肿瘤中的表达与细胞增殖和临床病理的关系[J].重庆医科大学学报,2005(05):47-49+56.

WANG Shunhe, et al. Correlation of estrogen receptor expression to activity of cell proliferation and chincopathology in brain tumors. [J]. Journal of Chongqing Medical University (5).(2005)
[1]王顺和,王光辉,李园园,杨慧敏.ER在脑肿瘤中的表达与细胞增殖和临床病理的关系[J].重庆医科大学学报,2005(05):47-49+56. DOI： 10.13406/j.cnki.cyxb.2005.05.012.

WANG Shunhe, et al. Correlation of estrogen receptor expression to activity of cell proliferation and chincopathology in brain tumors. [J]. Journal of Chongqing Medical University (5).(2005) DOI： 10.13406/j.cnki.cyxb.2005.05.012.

摘要

目的:探讨脑肿瘤中激素受体ER的表达与肿瘤细胞增殖和临床病理的关系。方法:应用免疫组织化学SP法

检测ER和PCNA在64例脑肿瘤标本中的表达。结果:星形细胞瘤、室管膜瘤和髓母细胞瘤肿瘤细胞中ER表达的阳性率分别为39.47%（15/38）、35.71%（5/14）和41.60%（5/12）

PCNA阳性率分别为65.79%（25/38）、92.86%（13/14）和66.67%（8/12）

高度恶性星形细胞瘤（Ⅲ级）ER阳性率（42.8%）明显高于良性Ⅰ级（33.3%）。星形细胞瘤中ER与PCNA、ER与肿瘤分级及PCNA与肿瘤分级之间有显著相关性（P<0.05）。结论:ER在神经胶质瘤中表达随着肿瘤的恶性程度的增高而增加

PCNA的表达与恶性增殖正相关。推测ER可能参与了胶质细胞恶性生长以及原癌基因的调控过程。

Abstract

Objective:To explore the correlation of ER expression to the activity of cell proliferation and clinicopathology in brain tumors(astrocytomas

ependynomas

and medulloblastomas).Methods:The expression of ER and proliferating cell nuclear antigen(PCNA) were determined by SP immunohistochemical method in 64 cases of brain tumors tissues.Correlation ER expression with chinicopathological characteristics was studied.Results:The positive rates of ER expression in astrocytomas

ependynomas

and medulloblastomas were 39.47%(15/38)

35.71%(5/14) and 41.60%(5/12) respectively.Maliganat astrocytomas(42.8%) had a significantly higher ER expression rate compared with Benign astrocytomas(33.3%)(P<0.05).ER positive glial tumors had higher PCNA labeling index(LI)compared with ER negative glial tumors(P<0.01).The expression of ER in astrocytomas tissues was significantly related with PCNA.Conclusion:Frequency of ER occurrence is higher in highly malignant astrocytomas.ER expression is correlated with proliferative activity.The expressions of ER in astrocytomas is related to higher rate of cell proliferation and histological grated and may play a pivotal role in astrocytic tumor initiation and regulation of proto-oncogene.

关键词

雌激素受体星形细胞瘤增殖细胞核抗原免疫组织化学

Keywords

Estrogen receptor(ER)AstrocytomasProliferating cell nuclear antigen(PCNA)immunohistochemistry

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Expression and significance of FOXP3 in colon cancer cells

Expression of HIF-1α and Sema4D in pancreatic carcinoma and its clinical significance

HISTOCHEMICAL AND IMMUNOHISTOCHEMI- CAL STUDY OF MAMMAKY PAGET’S DISEASE

THE EXPRESSION AND SIGMFICANCE OF HMB45,S-100 PROTEIN AND VIMENTIN IN PRIMARY MALIGNANT MELANOMA

Histopathologic examination of uterine smooth muscle tumors

Related Author

Qiu Lei

Shao Hua

Miao Yongchang

Jia Rujiang

Yin Qingchen

Wang Xiuchao

Hou Liyan

Xu Chao

Related Institution

Department of Gastrointestinal Surgery,The Second People’s Hospital of Lianyungang City

Department of General Surgery,Handan Central Hospital

Department of Pancreatic Oncology,Tianjin Medical University Cancer Institute and Hospital

重庆医科大学临床学院眼科

广州中山医科大学中山眼科中心

⁰