Effect of group-based multimodal exercise combined with nutrition education on health-related physical fitness and related outcomes in perimenopausal and postmenopausal women：a clinical controlled trial

Zhou Jing; Yang Jialing; Luo Fuyao; Yu Lili; Yang Jian; Lei Xun

doi:10.13406/j.cnki.cyxb.004086

您当前的位置：

首页 >

文章列表页 >

Effect of group-based multimodal exercise combined with nutrition education on health-related physical fitness and related outcomes in perimenopausal and postmenopausal women：a clinical controlled trial

Clinical research | 更新时间：2026-05-13

- Effect of group-based multimodal exercise combined with nutrition education on health-related physical fitness and related outcomes in perimenopausal and postmenopausal women：a clinical controlled trial
- Journal of Chongqing Medical University Vol. 51, Issue 5, Pages: 679-688(2026)
- 作者机构：
  
  1.重庆医科大学公共卫生学院，重庆 400016
  2.重庆市第五人民医院公共卫生科，重庆 400062
  3.重庆医科大学附属第三医院妇产中心，重庆 401120
  4.重庆医科大学附属第三医院营养科，重庆 401120
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.004086
  CLC： R711.75
- Received：01 March 2026，
  
  Revised：2026-03-17，
  
  Accepted：18 March 2026，
  
  Published：28 May 2026
- 稿件说明：
移动端阅览
周靖，杨嘉玲，罗芙瑶，等.团体式多模式运动联合营养教育对围绝经期及绝经后女性健康体适能及相关结局的影响：一项临床对照试验[J].重庆医科大学学报，2026，51（5）：679-688.

Zhou Jing,Yang Jialing,Luo Fuyao,et al.Effect of group-based multimodal exercise combined with nutrition education on health-related physical fitness and related outcomes in perimenopausal and postmenopausal women：a clinical controlled trial[J].Journal of Chongqing Medical University,2026,51(5):679-688.
周靖，杨嘉玲，罗芙瑶，等.团体式多模式运动联合营养教育对围绝经期及绝经后女性健康体适能及相关结局的影响：一项临床对照试验[J].重庆医科大学学报，2026，51（5）：679-688. DOI： 10.13406/j.cnki.cyxb.004086.

Zhou Jing,Yang Jialing,Luo Fuyao,et al.Effect of group-based multimodal exercise combined with nutrition education on health-related physical fitness and related outcomes in perimenopausal and postmenopausal women：a clinical controlled trial[J].Journal of Chongqing Medical University,2026,51(5):679-688. DOI： 10.13406/j.cnki.cyxb.004086.

摘要

目的

探讨团体式多模式运动联合营养教育对围绝经期及绝经后女性健康体适能及相关结局指标的影响。

方法

纳入围绝经期及绝经后女性122例，其中对照组54例和干预组68例。干预组接受为期8周中等强度团体式多模式运动联合营养教育干预，每周3次、每次60 min；营养教育采用“线上为主、线下为辅”的形式，包括每日推送膳食指导卡片及在线答疑。对照组维持日常活动。组间基线比较采用独立样本

检验、Mann-Whitney

检验、Pearson

χ²

检验及Fisher精确检验；以第8周结局指标为因变量，在校正教育水平及相应基线值后，对正态分布指标采用协变量调整线性回归分析，对非正态分布结局指标采用Gamma分布广义线性模型分析，并采用Bonferroni法进行多重比较校正。

结果

2组基线特征中仅受教育水平差异有统计学意义（

0.05），其余指标差异均无统计学意义（均

0.05）。在校正受教育水平及相应基线值后，干预组多项健康体适能指标改善优于对照组，其中台阶指数［

=7.60，95%置信区间（confidence interval，CI）=4.87~10.33］、握力（

=0.90，95%CI=0.31~1.48）、跪式俯卧撑次数（

=5.77，95%CI=4.35~7.20）、30 s坐起次数（

=2.33，95%CI=1.47~3.20）、坐位体前屈（

=4.27，95%CI=3.14~5.41）及单脚闭眼站立时间（

=6.89，95%CI=4.50~9.23）差异均有统计学意义（均

0.05）；同时，体脂肪量下降、去脂体重增加（均

0.05）。次要结局中，饮食得分、社会支持、焦虑评分及体力活动水平差异均有统计学意义（均

0.05）。经Bonferroni校正后，体质指数（body mass index，BMI）和焦虑评分差异无统计学意义（校正后

0.05）。

结论

团体式多模式运动联合营养教育可能改善围绝经期及绝经后女性健康体适能，并对部分生活方式及心理社会结局产生积极影响，但上述结论仍需在更大样本和长期随访研究中进一步验证。

Abstract

Objective

To investigate the effect of group-based multimodal exercise combined with nutrition education on health-related physical fitness and related outcomes in perimenopausal and postmenopausal women.

Methods

A total of 122 perimenopausal and postmenopausal women were enrolled and divided into control group with 54 women and intervention group with 68 women. The women in the intervention group received moderate-intensity group-based multimodal exercise combined with nutrition education，for 60 minutes each time，3 times a week for 8 weeks； nutrition education was delivered online and offline，including daily dietary guidance cards and question-and-answer support. The women in the control group maintained their usual daily activities. The independent samples

-test，the Mann-Whitney

test，the Pearson chi-square test Fisher’s exact test were used for comparison of baseline data between groups； with outcome measures at week 8 as dependent variables，the covariate-adjusted linear regression analysis was used for normally distributed outcome measures after adjustment for educational level and the corresponding baseline value，and the generalized linear model with a Gamma distribution was used for non-normally distributed outcome measures； the Bonferroni method was used for multiple comparisons.

Results

As for baseline characteristics，there was only a significant difference in educational level between the two groups（

0.05），and there were no significant differences in all the other variables between the two groups（all

0.05）. After adjustment for educational level and the corresponding baseline value，the intervention group had greater improvements than the control group in multiple indicators for health-related physical fitness，including step index（

=7.60，95%CI=4.87-10.33，

0.05），handgrip strength（

=0.90，95%CI=0.31-1.48，

0.05），knee push-up repetitions（

=5.77，95%CI=4.35-7.20，

0.05），30-second sit-up repetitions（

=2.33，95%CI=1.47-3.20，

0.05），sit-and-reach performance（

=4.27，95%CI=3.14-5.41，

0.05），and single-leg stance time with eyes closed（

=6.89，95%CI=4.50-9.23，

0.05），as well as a significant reduction in body fat mass and a significant increase in fat-free mass（

0.05）. Among secondary outcomes，there were significant differences between the two groups in dietary score，social support，anxiety score，and physical activity level（

0.05）. After Bonferroni correction，there were no significant differences in body mass index and anxiety score between the two groups （adjusted

0.05）.

Conclusion

Group-based multimodal exercise combined with nutrition education may improve health-related physical fitness in perimenopausal and postmenopausal women and may also exert a positive effect on certain lifestyle and psychosocial outcomes. However，studies with a larger sample size and a longer follow-up period are needed for further confirmation.

关键词

Keywords

references

Dominguez S ， Lloyd LK ， Schmidt EA ， et al . Attitudes toward physical activity：identifying the relationships with health-related physical fitness and physical activity [J ] . Med Sci Phys Exerc ， 2002 ， 34 （ 5 ）： S64 ．

Garber CE ， Blissmer B ， Deschenes MR ， et al . American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory，musculoskeletal，and neuromotor fitness in apparently healthy adults：guidance for prescribing exercise [J ] . Med Sci Sports Exerc ， 2011 ， 43 （ 7 ）： 1334 - 1359 ．

谢敏豪，李红娟，王正珍，等 . 心肺耐力：体质健康的核心要素：以美国有氧中心纵向研究为例 [J ] . 北京体育大学学报， 2011 ， 34 （ 2 ）： 1 - 7 ．

Xie MH ， Li HJ ， Wang ZZ ， et al . Cardiorespiratory fitness：a core component of health-related physical fitness：introduction to the aerobics center longitudinal study [J ] . J Beijing Sport Univ ， 2011 ， 34 （ 2 ）： 1 - 7 ．

Lovejoy JC ， Champagne CM ， de Jonge L ， et al . Increased visceral fat and decreased energy expenditure during the menopausal transition [J ] . Int J Obes ， 2008 ， 32 （ 6 ）： 949 - 958 ．

Mensah Bonsu I ， Brandt C ， Ajidahun AT ， et al . Physical activity，lifestyle，sociocultural factors and prevalence of excess weight gain among postmenopausal women：A cross-sectional study [J ] . Womens Health ， 2023 ， 19 ： 17455057231184508 ．

Critchlow AJ ， Alexander SE ， Hiam DS ， et al . Associations between female sex hormones and skeletal muscle ageing：the Baltimore longitudinal study of aging [J ] . J Cachexia Sarcopenia Muscle ， 2025 ， 16 （ 3 ）： e13786 ．

Lee E ， Anselmo M ， Tahsin CT ， et al . Vasomotor symptoms of menopause，autonomic dysfunction，and cardiovascular disease [J ] . Am J Physiol Heart Circ Physiol ， 2022 ， 323 （ 6 ）： 1270 - 1280 ．

Duan HX ， Wang H ， Bai YW ， et al . Health-related physical fitness as a risk factor for falls in elderly people living in the community：a prospective study in China [J ] . Front Public Health ， 2022 ， 10 ： 874993 ．

Hansen M ， Gliemann L ， Hellsten Y . Optimizing female health：the crucial role of exercise initiation before and during the menopausal transition [J ] . Exerc Sport Sci Rev ， 2025 ， 53 （ 4 ）： 195 - 204 ．

Andarzi F ， Jahromi MK . Correlation between physical activity，appetite，and body composition during menopausal transition and postmenopause in Iranian women [J ] . Womens Health ， 2024 ， 20 ： 17455057241292859 ．

Anekwe CV ， Cano A ， Mulligan J ， et al . The role of lifestyle medicine in menopausal health：a review of non-pharmacologic interventions [J ] . Climacteric ， 2025 ， 28 （ 5 ）： 478 - 496 ．

Marsh ML ， Oliveira MN ， Vieira-Potter VJ . Adipocyte metabolism and health after the menopause：the role of exercise [J ] . Nutrients ， 2023 ， 15 （ 2 ）： 444 ．

Yue HY ， Yang YJ ， Xie FF ， et al . Effects of physical activity on depressive and anxiety symptoms of women in the menopausal transition and menopause：a comprehensive systematic review and meta-analysis of randomized controlled trials [J ] . Int J Behav Nutr Phys Act ， 2025 ， 22 （ 1 ）： 13 ．

Greendale GA ， Jackson NJ ， Shieh A ， et al . Leisure time physical activity and bone mineral density preservation during the menopause transition and postmenopause：a longitudinal cohort analysis from the Study of Women’s Health Across the Nation（SWAN） [J ] . Lancet Reg Health Am ， 2023 ， 21 ： 100481 ．

Hartman SJ ， LaCroix AZ ， Sears DD ， et al . Impacts of reducing sitting time or increasing sit-to-stand transitions on blood pressure and glucose regulation in postmenopausal women：three-arm randomized controlled trial [J ] . Circulation ， 2025 ， 152 （ 8 ）： 492 - 504 ．

何海洋，雷　迅，俞丽丽 . 运动在绝经综合征防治和绝经激素治疗风险预防的应用研究进展 [J ] . 中华健康管理学杂志， 2023 ， 17 （ 8 ）： 623 - 626 ．

He HY ， Lei X ， Yu LL . Research progress on the application of exercise in the prevention and treatment of menopausal syndrome and risk prevention of menopausal hormone therapy [J ] . Chin J Health Manag ， 2023 ， 17 （ 8 ）： 623 - 626 ．

Svensen E ， Koscien CP ， Alamdari N ， et al . A novel low-impact resistance exercise program increases strength and balance in females irrespective of menopause status [J ] . Med Sci Sports Exerc ， 2025 ， 57 （ 3 ）： 501 - 513 ．

Su CH ， Peng HY ， Tien CW ， et al . Effects of a 12-week Pilates program on functional physical fitness and basal metabolic rate in community-dwelling middle-aged women：a quasi-experimental study [J ] . Int J Environ Res Public Health ， 2022 ， 19 （ 23 ）： 16157 ．

Moore SR ， Cabre HE ， Smith-Ryan AE . Body composition，physical activity，and menopause symptoms：how do they relate? [J ] . Menopause ， 2024 ， 31 （ 4 ）： 336 - 341 ．

Carneiro MAS ， Kassiano W ， Oliveira-Júnior G ， et al . Effect of different load intensity transition schemes on muscular strength and physical performance in postmenopausal women [J ] . Med Sci Sports Exerc ， 2023 ， 55 （ 8 ）： 1507 - 1523 ．

Tan A ， Thomas RL ， Campbell MD ， et al . Effects of exercise training on metabolic syndrome risk factors in post-menopausal women-A systematic review and meta-analysis of randomised controlled trials [J ] . Clin Nutr ， 2023 ， 42 （ 3 ）： 337 - 351 ．

Grigolon RB ， Ceolin G ， Deng Y ， et al . Effects of nutritional inter⁃ventions on the severity of depressive and anxiety symptoms of women in the menopausal transition and menopause：a systematic review，meta analysis，and meta-regression [J ] . Menopause ， 2023 ， 30 （ 1 ）： 95 - 107 .

Hybholt M . Psychological and social health outcomes of physical activity around menopause：A scoping review of research [J ] . Maturitas ， 2022 ， 164 ： 88 - 97 ．

Choudhary A ， Bansal K . Menopause and movement：exercise for better sleep and psychological well-being-a systematic review [J ] . Menopause ， 2025 ， 32 （ 11 ）： 1063 - 1071 ．

Casey M ， Dabkowski E ， de Gracia MRL ， et al . Socioecological factors influencing physical activity engagement for women across the menopausal transition：a systematic review [J ] . Menopause ， 2024 ， 31 （ 5 ）： 433 - 446 ．

Li YM ， He HY ， Wang JX ， et al . Effect of multidisciplinary health education based on lifestyle medicine on menopausal syndrome and lifestyle behaviors of menopausal women：A clinical controlled study [J ] . Front Public Health ， 2023 ， 11 ： 1119352 ．

杨嘉玲，黄滢珠，周　靖，等 . 围绝经期女性参与团体式公益运动课程真实体验的质性研究 [J ] . 中华现代护理杂志， 2025 ， 31 （ 3 ）： 314 - 320 ．

Yang JL ， Huang YZ ， Zhou J ， et al . Real experience of perimenopausal women participating in group public welfare exercise program：a qualitative research [J ] . Chin J Mod Nurs ， 2025 ， 31 （ 3 ）： 314 - 320 ．

Martínez-Carbonell E ， López-Vivancos A ， Romero-Arenas S ， et al . Impact of multicomponent training frequency on health and fitness parameters in postmenopausal women：a comparative study [J ] . Healthcare ， 2024 ， 12 （ 19 ）： 1980 ．

Lewis BA ， Schuver KJ ， Swinney KB ， et al . Examining the feasibility and preliminary efficacy of a group-based physical activity intervention integrating strength training among pre- and perimenopausal women：A randomized pilot trial [J ] . Womens Health ， 2025 ， 21 ： 17455057251361243 ．

Daly RM ， Gianoudis J ， Kersh ME ， et al . Effects of a 12-month supervised，community-based，multimodal exercise program followed by a 6-month research-to-practice transition on bone mineral density，trabecular microarchitecture，and physical function in older adults：a randomized controlled trial [J ] . J Bone Miner Res ， 2020 ， 35 （ 3 ）： 419 - 429 ．

Liu CM ， Lin KF . Estimation of V̇O₂max：a comparative analysis of post-exercise heart rate and physical fitness index from 3-minute step test [J ] . J Exerc Sci Fit ， 2007 ， 5 ： 118 - 123 .

Rikli RE ， Jones CJ . Senior Fitness Test Manual [M ] . Champaign，IL ： Human Kinetics ， 2001

Wells KF ， Dillon EK . The sit and reach：a test of back and leg flexibility [J ] . Res Q Am Assoc Health Phys Educ Recreat ， 1952 ， 23 （ 1 ）： 115 - 118 ．

Reidpath DD ， Cheah JC ， Lam FC ， et al . Validity of self-measured waist and hip circumferences：results from a community study in Malaysia [J ] . Nutr J ， 2013 ， 12 ： 135 ．

World Health Organization . Physical status：the use of and interpretation of anthropometry，report of a WHO expert committee [R/OL ] . [ 2026-03-09 ] . https://www.who.int/publications/i/item/9241208546 https://www.who.int/publications/i/item/9241208546

Tao MF ， Shao HF ， Li CB ， et al . Correlation between the modified kupperman index and the menopause rating scale in Chinese women [J ] . Patient Prefer Adherence ， 2013 ， 7 ： 223 - 229 ．

Spitzer RL ， Kroenke K ， Williams JBW ， et al . A brief measure for assessing generalized anxiety disorder：the GAD-7 [J ] . Arch Intern Med ， 2006 ， 166 （ 10 ）： 1092 - 1097 ．

Kroenke K ， Spitzer RL ， Williams JB . The PHQ-9：validity of a brief depression severity measure [J ] . J Gen Intern Med ， 2001 ， 16 （ 9 ）： 606 - 613 ．

Hagströmer M ， Oja P ， Sjöström M . The International Physical Activity Questionnaire （IPAQ）：a study of concurrent and construct validity [J ] . Public Health Nutr ， 2006 ， 9 （ 6 ）： 755 - 762 ．

肖水源 . 《社会支持评定量表》的理论基础与研究应用 [J ] . 临床精神医学杂志， 1994 （ 2 ）： 98 - 100 ．

Xiao SY . Theoretical basis and research application of social support rating scale [J ] . J Clin Psychol Med ， 1994 （ 2 ）： 98 - 100 ．

Rael B ， Barba-Moreno L ， Romero-Parra N ， et al . Cardiorespiratory response to exercise in endurance-trained premenopausal and postmenopausal females [J ] . Eur J Appl Physiol ， 2021 ， 121 （ 3 ）： 903 - 913 ．

廖　琛，凌瑞恩，农丽颖 . 运动康复视角下Cross Fit组合练习对中年女性健康体适能的影响研究 [J ] . 体育科技， 2022 ， 43 （ 2 ）： 8 - 10，13 ．

Liao C ， Ling RE ， Nong LY . An empirical study on the influence of cross fit combination exercise on middle-aged women’s physical fitness from the perspective of sports rehabilitation specialty [J ] . Sport Sci Technol ， 2022 ， 43 （ 2 ）： 8 - 10，13 ．

Hettchen M ， von Stengel S ， Kohl M ， et al . Changes in menopausal risk factors in early postmenopausal osteopenic women after 13 months of high-intensity exercise：the randomized controlled ACTLIFE-RCT [J ] . Clin Interv Aging ， 2021 ， 16 ： 83 - 96 ．

Bai XR ， Xiao WS ， Soh KG ， et al . A 12-week Taijiquan practice improves balance control and functional fitness in fall-prone postmenopausal women [J ] . Front Public Health ， 2024 ， 12 ： 1415477 ．

Koçak M ， Şevgin Ö . The effect of exercise on menstrual symptoms：a randomized controlled trial [J ] . BMC Womens Health ， 2025 ， 25 （ 1 ）： 406 ．

Batrakoulis A ， Jamurtas AZ ， Fatouros IG . High-intensity interval training in metabolic diseases：physiological adaptations [J ] . ACSM’S Health Fit J ， 2021 ， 25 （ 5 ）： 54 - 59 ．

Newsome AM ， Reed R ， Sansone J ， et al . 2024 ACSM worldwide fitness trends：future directions of the health and fitness industry [J ] . ACSM’S Health Fit J ， 2024 ， 28 （ 1 ）： 14 - 26 ．

Batrakoulis A ， Jamurtas AZ ， Metsios GS ， et al . Comparative efficacy of 5 exercise types on cardiometabolic health in overweight and obese adults：a systematic review and network meta-analysis of 81 randomized controlled trials [J ] . Circ Cardiovasc Qual Outcomes ， 2022 ， 15 （ 6 ）： e008243 ．

Hurst C ， Robinson SM ， Witham MD ， et al . Resistance exercise as a treatment for sarcopenia：prescription and delivery [J ] . Age Ageing ， 2022 ， 51 （ 2 ）： afac003 ．

Hita-Contreras F ， Martínez-Amat A ， Cruz-Díaz D ， et al . Fall prevention in postmenopausal women：the role of Pilates exercise training [J ] . Climacteric ， 2016 ， 19 （ 3 ）： 229 - 233 ．

Juppi HK ， Sipilä S ， Fachada V ， et al . Total and regional body adiposity increases during menopause-evidence from a follow-up study [J ] . Aging Cell ， 2022 ， 21 （ 6 ）： e13621 ．

Rios M ， Pyne DB ， Fernandes RJ . The effects of CrossFit（ ® ） practice on physical fitness and overall quality of life [J ] . Int J Environ Res Public Health ， 2024 ， 22 （ 1 ）： 19 ．

Taylor J ， Stratton E ， McLean L ， et al . How junior doctors perceive personalised Yoga and group exercise in the management of occupational and traumatic stressors [J ] . Postgrad Med J ， 2022 ， 98 （ 1161 ）： e10 ．

Prochnow T ， Amo C ， Patterson MS ， et al . I CrossFit；do you?cross-sectional peer similarity of physical activity behavior in a group high intensity functional training setting [J ] . Int J Environ Res Public Health ， 2022 ， 19 （ 9 ）： 4932 ．

Nappi RE . The 2022 hormone therapy position statement of The North American Menopause Society：no news is good news [J ] . Lancet Diabetes Endocrinol ， 2022 ， 10 （ 12 ）： 832 - 834 ．

Baena-García L ， Flor-Alemany M ， Marín-Jiménez N ， et al . A 16-week multicomponent exercise training program improves menopause-related symptoms in middle-aged women. The FLAMENCO project randomized control trial [J ] . Menopause ， 2022 ， 29 （ 5 ）： 537 - 544 ．

Shing CLH , Bond B , Moreau KL , et al . The therapeutic role of exercise training during menopause for reducing vascular disease [J ] . Experimental Physiology ， 2024 . Epub ahead of print . https://doi.org/10.1113/EP092191 https://doi.org/10.1113/EP092191 .

Koçoğlu S ， Şevgin Ö ， Hoşbaş BD . Comparison of motor imagery focused pelvic floor exercises and relaxation exercises for treating dysmenorrhea：A randomized controlled study [J ] . Taiwan J Obstet Gynecol ， 2025 ， 64 （ 4 ）： 671 - 677 ．

Dugan SA ， Bromberger JT ， Segawa E ， et al . Association between physical activity and depressive symptoms：midlife women in SWAN [J ] . Med Sci Sports Exerc ， 2015 ， 47 （ 2 ）： 335 - 342 ．

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Role of interleukin-38 in regulating the expression of enzyme genes in the glutamine metabolic network of EL4 cells after T cell receptor signal activation

Association of early red blood cell distribution width with initiation of continuous renal replacement therapy in patients with sepsis

Research advances in immunometabolic regulation of cytokine storm in sepsis

Research advances in urosepsis and critical care management strategies

Doses to organs at risk in radiotherapy for cervical cancer based on dose-volume histogram and International Commission on Radiation Units and Measurements Report 89: a comparative study

Related Author

No data

Related Institution

No data

⁰