Doses to organs at risk in radiotherapy for cervical cancer based on dose-volume histogram and International Commission on Radiation Units and Measurements Report 89: a comparative study

Wang Shanshan; Song Yanbo

doi:10.13406/j.cnki.cyxb.004069

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Doses to organs at risk in radiotherapy for cervical cancer based on dose-volume histogram and International Commission on Radiation Units and Measurements Report 89: a comparative study

Clinical research | 更新时间：2026-06-11

- Doses to organs at risk in radiotherapy for cervical cancer based on dose-volume histogram and International Commission on Radiation Units and Measurements Report 89: a comparative study
- Journal of Chongqing Medical University Vol. 51, Issue 6, Pages: 876-881(2026)
- 作者机构：
  
  重庆医科大学附属第一医院肿瘤科/重庆市卫生健康委员会免疫、炎症与肿瘤重点实验室，重庆　400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.004069
  CLC： R737.33
- Received：27 November 2025，
  
  Revised：2026-02-08，
  
  Accepted：24 February 2026，
  
  Published：28 June 2026
- 稿件说明：
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王珊珊，宋延波.基于DVH和ICRU-89号报告评估宫颈癌放射治疗危及器官剂量的对比研究[J].重庆医科大学学报，2026，51（6）：876-881.

Wang Shanshan,Song Yanbo.Doses to organs at risk in radiotherapy for cervical cancer based on dose-volume histogram and International Commission on Radiation Units and Measurements Report 89: a comparative study[J].Journal of Chongqing Medical University,2026,51(6):876-881.
王珊珊，宋延波.基于DVH和ICRU-89号报告评估宫颈癌放射治疗危及器官剂量的对比研究[J].重庆医科大学学报，2026，51（6）：876-881. DOI： 10.13406/j.cnki.cyxb.004069.

Wang Shanshan,Song Yanbo.Doses to organs at risk in radiotherapy for cervical cancer based on dose-volume histogram and International Commission on Radiation Units and Measurements Report 89: a comparative study[J].Journal of Chongqing Medical University,2026,51(6):876-881. DOI： 10.13406/j.cnki.cyxb.004069.

摘要

目的

探讨宫颈癌患者外照射联合近距离放射治疗时，基于外照射阶段剂量-体积直方图（dose-volume histogram，DVH）获取的危及器官（organs at risk，OARs）（比如膀胱、直肠等）的剂量与国际辐射单位与测量委员会（International Commission on Radiation Units and Measurements，ICRU）89号报告推荐方法计算的OARs剂量进行比较，分析两者间的差异。

方法

回顾性纳入100例行外照射联合近距离放射治疗的宫颈癌患者，外照射剂量为45 Gy（1.8 Gy/次×25次，每日1次，每周5次）。从DVH上获取膀胱、直肠的D

2cc

、D

0.1cc

剂量并转换为2 Gy等效生物剂量（equivalent dose in 2 Gy fractions，EQD2），与ICRU剂量（ICRU-89号报告推荐方法计算OARs的EQD2剂量43.20 Gy）进行比较。

结果

DVH上膀胱D

2cc

、D

0.1cc

平均EQD2剂量分别为（45.97±0.59） Gy、（46.67±0.55） Gy，较ICRU剂量分别高出6.4%（

0.001）、8.0%（

0.001）；直肠D

2cc

、D

0.1cc

平均EQD2剂量分别为（45.46±0.89） Gy、（46.34±0.73） Gy，比ICRU剂量分别高出5.2%（

0.001）、7.3%（

0.001）。

结论

宫颈癌外照射联合近距离放射治疗时，采用ICRU-89号报告推荐方法计算外照射阶段OARs的受照射剂量明显低于从DVH上获取的实际受照射剂量，从而低估宫颈癌外照射联合近距离治疗时OARs的总受照射剂量，可能增加放射性膀胱炎、直肠炎的发生风险。建议在宫颈癌外照射联合近距离放射治疗时，根据DVH实际剂量评估OARs的受照剂量。

Abstract

Objective

To investigate the differences in the doses to organs at risk（OARs）（bladder and rectum） derived from dose-volume histogram （DVH） during external beam radiotherapy versus those calculated by the method recommended in International Commission on Radiation Units and Measurements（ICRU） Report 89 in patients with cervical cancer undergoing external beam radiotherapy combined with brachytherapy.

Methods

A retrospective analysis was performed for 100 patients with cervical cancer who received external beam radiotherapy combined with brachytherapy，with a dose of 45 Gy（25 fractions of 1.8 Gy，once daily，5 times per week） for external beam radiotherapy. The D

2cc

and D

0.1cc

doses of the bladder and the rectum were obtained from the DVH and were converted to equivalent dose in 2 Gy fractions（EQD2），which were then compared with the ICRU dose （i.e.，the EQD2 dose of 43.20 Gy for OARs calculated by the method recommended in ICRU Report 89）.

Results

The mean EQD2 doses of bladder D

2cc

and D

0.1cc

obtained from the DVH were （45.97±0.59） Gy and （46.67±0.55） Gy，respectively，which were 6.4%（

0.001） and 8.0%（

0.001） higher than the ICRU dose；the mean EQD2 doses of rectum D

2cc

and D

0.1cc

obtained from the DVH were （45.46±0.89） Gy and （46.34±0.73） Gy，respectively，which were 5.2%（

0.001） and 7.3%（

0.001） higher than the ICRU dose.

Conclusion

For patients with cervical cancer undergoing external beam radiotherapy combined with brachytherapy，the doses to OARs calculated using the method recommended in ICRU Report 89 during external beam radiotherapy are significantly lower than the actual doses derived from DVH，thereby underestimating the total doses to OARs，which may increase the incidence rates of radiation-induced cystitis and proctitis. It is recommended to evaluate the doses to OARs based on the actual doses obtained from the DVH during external beam radiotherapy combined with brachytherapy for cervical cancer.

关键词

Keywords

references

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