1.广西壮族自治区人民医院重症医学科,南宁 530021
2.南方医科大学南方医院重症医学科,广州 510515
Received:17 December 2025,
Revised:2026-01-15,
Accepted:21 January 2026,
Published:28 April 2026
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张记旺,向淑麟,熊滨,等.新药环泊酚麻醉-镇静治疗对患者血压影响的研究进展[J].重庆医科大学学报,2026,51(4):536-539.
Zhang Jiwang,Xiang Shulin,Xiong Bin,et al.Research advances in the effect of ciprofol anesthesia-sedation on blood pressure[J].Journal of Chongqing Medical University,2026,51(4):536-539.
张记旺,向淑麟,熊滨,等.新药环泊酚麻醉-镇静治疗对患者血压影响的研究进展[J].重庆医科大学学报,2026,51(4):536-539. DOI: 10.13406/j.cnki.cyxb.004056.
Zhang Jiwang,Xiang Shulin,Xiong Bin,et al.Research advances in the effect of ciprofol anesthesia-sedation on blood pressure[J].Journal of Chongqing Medical University,2026,51(4):536-539. DOI: 10.13406/j.cnki.cyxb.004056.
环泊酚作为我国自主研发的Ⅰ类创新静脉麻醉-镇静药物,具有起效迅速、恢复快、注射痛发生率低等优势,近年来已广泛应用于临床麻醉与重症镇静。既往研究表明,环泊酚在麻醉与镇静效果方面不劣于丙泊酚,且在血流动力学稳定性方面,尤其是在降低低血压发生率方面,显示出潜在优势。本文围绕环泊酚的药理学特性、临床研究进展及其对血压的影响进行系统综述,重点分析其在成人手术麻醉、日间诊疗、儿科患者及重症监护室(intensive care unit,ICU)镇静中的应用证据,并探讨当前研究的局限性与未来发展方向,以期为临床合理选择麻醉与镇静策略提供参考。
Ciprofol is a novel drug for intravenous anesthesia-sedation independently developed by China,with the advantages of rapid onset,quick recovery,and a low incidence rate of injection pain,and it has been widely used in clinical anesthesia and sedation in severe cases in recent years. Previous studies have shown that ciprofol is not inferior to propofol in the efficacy of anesthesia and sedation and shows potential in hemodynamic stability,especially in reducing the incidence rate of hypotension. This article reviews the pharmacological features of ciprofol,the advances in clinical research,and the effect of ciprofol on blood pressure,with a focus on its application in surgical anesthesia for adults,daytime diagnosis and treatment,pediatric patients,and sedation in the intensive care unit (ICU). It also discusses the limitations of current studies and the directions for future research,in order to provide a reference for selection of appropriate anesthesia and sedation strategies in clinical practice.
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