Applicability and regional adjustment of the six-minute walk distance prediction equation for children in Chongqing，China

Luo Yi; Wu Liping; Liu Yulin

doi:10.13406/j.cnki.cyxb.004052

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Applicability and regional adjustment of the six-minute walk distance prediction equation for children in Chongqing，China

Clinical research | 更新时间：2026-05-13

- Applicability and regional adjustment of the six-minute walk distance prediction equation for children in Chongqing，China
- Journal of Chongqing Medical University Vol. 51, Issue 5, Pages: 715-721(2026)
- 作者机构：
  
  1.重庆医科大学附属儿童医院呼吸科，国家儿童健康与疾病临床医学研究中心，儿童发育疾病研究教育部重点实验室，儿童神经发育与认知障碍重庆市重点实验室，重庆 400014
  2.重庆医科大学附属儿童医院护理部，重庆 400014
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.004052
  CLC： R720.4
- Received：30 September 2025，
  
  Revised：2026-01-07，
  
  Accepted：13 January 2026，
  
  Published：28 May 2026
- 稿件说明：
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罗艺，吴利平，刘玉琳.儿童六分钟步行距离预测方程在重庆地区的适用性评价及本土化修正[J].重庆医科大学学报，2026，51（5）：715-721.

Luo Yi,Wu Liping,Liu Yulin.Applicability and regional adjustment of the six-minute walk distance prediction equation for children in Chongqing，China[J].Journal of Chongqing Medical University,2026,51(5):715-721.
罗艺，吴利平，刘玉琳.儿童六分钟步行距离预测方程在重庆地区的适用性评价及本土化修正[J].重庆医科大学学报，2026，51（5）：715-721. DOI： 10.13406/j.cnki.cyxb.004052.

Luo Yi,Wu Liping,Liu Yulin.Applicability and regional adjustment of the six-minute walk distance prediction equation for children in Chongqing，China[J].Journal of Chongqing Medical University,2026,51(5):715-721. DOI： 10.13406/j.cnki.cyxb.004052.

摘要

目的

验证香港儿童六分钟步行距离（six-minute walk distance，6MWD）预测方程在重庆地区的适用性，并建立本土化修正方程，形成区域性参考标准。

方法

选取重庆市744例7~12岁健康儿童（男358例，女386例），进行标准化的六分钟步行试验（six-minute walk test，6MWT）。系统比较重庆儿童与香港参照人群的生长指标及6MWD分布，并采用配对

检验、Bland-Altman一致性分析及均方根误差（root mean square error，RMSE）等量化香港方程的预测偏差。基于重庆本地数据，以测试前后心率差值（change in heart rate，ΔHR）和身高为自变量，通过多元线性回归建立性别特异性的本土化6MWD预测方程。

结果

重庆儿童主要年龄段的体格指标及6MWD实测值低于香港同龄儿童。香港方程预测值明显高估（平均偏差+184.67 m，RMSE=198.16 m）。本土化修正方程分别为：男童，6MWD=251.43+2.14×ΔHR+1.55×身高；女童，6MWD=288.61+1.83×ΔHR+1.30×身高（模型解释度良好，决定系数（

²）=0.544/0.479）。新方程预测精度明显提高（RMSE降至50.19 m），与实测值相关性增强（

=0.719），

且消除了系统性偏差。

结论

香港方程在重庆儿童中适用性较差。本研究构建的重庆本土化修正方程拟合优度良好、预测精准，为建立重庆地区儿童6MWD参考值提供了可靠依据。

Abstract

Objective

To investigate the applicability of the Hong Kong-based six-minute walk distance（6MWD） prediction equation in children in Chongqing，China，to establish locally adapted equations，and to formulate a regional reference standard.

Methods

A total of 744 healthy children （358 boys and 386 girls） aged 7-12 years from Chongqing were enrolled，and the standardized six-minute walk test（6MWT） was performed. Growth indicators and 6MWD distribution were systematically compared between the Chongqing cohort and the Hong Kong reference population，and the paired

-test，Bland-Altman agreement analysis，and root mean square error （RMSE） were used to quantify the predictive bias of the Hong Kong equation. Based on the local data of Chongqing and with the change in heart rate（ΔHR） and height as independent variables，multiple linear regression was used to establish localized sex-specific 6MWD prediction equations.

Results

The Chongqing children generally had lower anthropometric measures and 6MWD measured values in key age groups compared with their Hong Kong peers. The Hong Kong equation significantly overestimated 6MWD in the Chongqing cohort，with a mean bias of +184.67 m and an RMSE of 198.16 m. The newly established localized equations were 6MWD=251.43+2.14×ΔHR+1.55×height for boys and 6MWD=288.61+1.83×ΔHR+1.30×height for girls，with satisfactory model explanation（

=0.544/0.479）. The new equations had a significant improvement in predictive accuracy（RMSE decreased to 50.19 m），a stronger correlation with measured values（

=0.719），and the elimination of systematic bias.

Conclusion

The Hong Kong-based equation has poor applicability in children in Chongqing. The locally adapted equations for Chongqing developed in this study show a good degree of fitting and accurate prediction，which provides a reliable basis for establishing 6MWD reference values for children in Chongqing.

关键词

Keywords

references

贾晓慧，胡师东 . 儿童呼吸康复的评估技术 [J ] . 中国实用儿科杂志， 2024 ， 39 （ 8 ）： 575 - 579 ．

Jia XH ， Hu SD . Assessment techniques for pediatric pulmonary rehabilitation [J ] . Chin J Pract Pediatr ， 2024 ， 39 （ 8 ）： 575 - 579 ．

Ishaaya E ， Yee N ， DeCato TW . Six-minute walk testing： performance，properties，and clinical applications [J ] . Clin Chest Med ， 2025 ， 46 （ 3 ）： 467 - 479 ．

Qu JB ， Shi H ， Guo YG ， et al . Is the six-minute walk test still reliable compared to cardiopulmonary exercise test for exercise capacity in children with congenital heart disease? [J ] . Front Pediatr ， 2022 ， 10 ： 965739 ．

Coulshed A ， Coulshed D ， Pathan F . Systematic review of the use of the 6-minute walk test in measuring and improving prognosis in patients with ischemic heart disease [J ] . CJC Open ， 2023 ， 5 （ 11 ）： 816 - 825 ．

Alhammad SA ， Alqahtani AS ， Alwadeai KS ， et al . Walking capacity and its association with quality of life among children with down syndrome in Saudi Arabia [J ] . BMC Pediatr ， 2024 ， 24 （ 1 ）： 55 ．

Wosiak AM ， Stasiak A ， Smolewska E . Physical activity in children with juvenile idiopathic arthritis： a review of recent literature [J ] . Reumatologia ， 2025 ， 63 （ 3 ）： 191 - 201 ．

Ballal Tahaelbashir SE ， Birima Noureldin WN ， Toto Korea IK ， et al . Aerobic exercise-based pulmonary rehabilitation for bronchial asthma in pediatrics： a systematic review [J ] . Cureus ， 2025 ， 17 （ 11 ）： e96568 ．

Salazar G ， Vásquez F ， Concha F ， et al . The influence of body composition on the six-minute walk test in Chilean preschool and school children [J ] . Nutr Hosp ， 2022 ， 39 （ 1 ）： 27 - 32 ．

de Assis Pereira Cacau L ， Carvalho VO ， Dos Santos Pin A ， et al . Reference values for the 6-Min walk distance in healthy children age 7 to 12 years in Brazil： main results of the TC6minBrasil multi-center study [J ] . Respir Care ， 2018 ， 63 （ 3 ）： 339 - 346 ．

Ubuane PO ， Ajiboye OA ， Adekunle MO ， et al . Reference values and equations for the 6-minute walk distance of Nigerian children aged 6-11 years： A cross-sectional study [J ] . Pediatr Pulmonol ， 2022 ， 57 （ 9 ）： 2103 - 2115 ．

Latorre Román PA ， Salazar CM ， Montilla JAP ， et al . Reference values in the 6-minute walk test in Chilean children aged 3-10 years and relationship with cardiometabolic risk [J ] . Pediatr Exerc Sci ， 2024 ， 37 （ 1 ）： 54 - 61 ．

Kahraman BO ， Yuksel E ， Nalbant A ， et al . Arm span as a predictor of the six-minute walk test in healthy children [J ] . Braz J Phys Ther ， 2021 ， 25 （ 3 ）： 281 - 285 ．

Li AM ， Yin J ， Au JT ， et al . Standard reference for the six-minute-walk test in healthy children aged 7 to 16 years [J ] . Am J Respir Crit Care Med ， 2007 ， 176 （ 2 ）： 174 - 180 ．

国家质量监督检验检疫总局，中国国家标准化管理委员会 . 学生健康检查技术规范： GB/T 26343—2010 [S ] . 北京：中国标准出版社， 2011 ．

General Administration of Quality Supervision ， Inspection and Quarantine of the People’s Republic of China ， Standardization Administration of the People’s Republic of China . Technical standard for physical examination for students ： GB/T 26343—2010 [S ] . Beijing ： Standards Press of China ， 2011 ．

ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories . ATS statement： guidelines for the six-minute walk test [J ] . Am J Respir Crit Care Med ， 2002 ， 166 （ 1 ）： 111 - 117 ．

Holland AE ， Spruit MA ， Troosters T ， et al . An official European Respiratory Society/American Thoracic Society technical standard： field walking tests in chronic respiratory disease [J ] . Eur Respir J ， 2014 ， 44 （ 6 ）： 1428 - 1446 ．

中华医学会心血管病学分会，中国康复医学会心肺预防与康复专业委员会，中华心血管病杂志编辑委员会 . 六分钟步行试验临床规范应用中国专家共识 [J ] . 中华心血管病杂志， 2022 ， 50 （ 5 ）： 432 - 442 ．

Chinese Society of Cardiology ， Cardiopulmonary Prevention and Rehabilitation Committee of Chinese Association of Rehabilitation Medicine ， Editorial Board of Chinese Journal of Cardiology . Chinese expert consensus on standardized clinical application of 6-minute walk test [J ] . Chin J Cardiol ， 2022 ， 50 （ 5 ）： 432 - 442 ．

Heinicke G ， Clay R ， DeCato TW . Six-minute-walk testing [J ] . Am J Respir Crit Care Med ， 2021 ， 204 （ 3 ）： P5 - P6 ．

de Andrade Guimarães AL ， Gomes Neto M ， Carvalho VO . Can the use of reference values for the 6-Min walk test from another country result in misinterpretation? [J ] . Pediatr Pulmonol ， 2022 ， 57 （ 11 ）： 2866 - 2867 ．

Corda J ， Holland AE ， Tannenbaum EL ， et al . Clinimetric properties of field exercise tests in cystic fibrosis： a systematic review [J ] . Eur Respir Rev ， 2024 ， 33 （ 174 ）： 240142 ．

Ghouili H ， Dergaa I ， Dridi A ， et al . Developing normative values and predictive models for the 6-minute walk test across diverse adolescent developmental stages [J ] . Eur J Sport Sci ， 2024 ， 24 （ 9 ）： 1365 - 1378 ．

Kasović M ， Štefan L ， Petrić V . Normative data for the 6-Min walk test in 11-14 year-olds： a population-based study [J ] . BMC Pulm Med ， 2021 ， 21 （ 1 ）： 297 ．

Del Corral T ， Tapia-Castañeda J ， Ríos-Pérez G ， et al . Assessment of the determinants of changes and test-retest reliability in the 6-Min walk test performance over a 4-month period in healthy 6-12-year-old children [J ] . Eur J Appl Physiol ， 2022 ， 122 （ 4 ）： 935 - 944 ．

Reyes A ， Chaves R ， Vasconcelos O ， et al . Modeling the dynamics of children’s musculoskeletal fitness [J ] . Int J Environ Res Public Health ， 2023 ， 20 （ 4 ）： 2938 ．

Sulla-Torres J ， Vidal-Espinoza R ， Avendaño-Llanque C ， et al . Reference values for the 6-Min walking test in children and adolescents living in a moderate altitude region of Peru [J ] . BMC Pediatr ， 2024 ， 24 （ 1 ）： 141 ．

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