Zhang Shenrui,Xiao Xinhua,Zheng Jia.Research advances in plasma lipid metabolites for predicting the progression of gestational diabetes mellitus to postpartum type 2 diabetes mellitus[J].Journal of Chongqing Medical University,2026,51(01):16-20.
Zhang Shenrui,Xiao Xinhua,Zheng Jia.Research advances in plasma lipid metabolites for predicting the progression of gestational diabetes mellitus to postpartum type 2 diabetes mellitus[J].Journal of Chongqing Medical University,2026,51(01):16-20. DOI: 10.13406/j.cnki.cyxb.003971.
Research advances in plasma lipid metabolites for predicting the progression of gestational diabetes mellitus to postpartum type 2 diabetes mellitus
Gestational diabetes mellitus(GDM) is one of the most common pregnancy complications,and its incidence has been gradually increasing year by year. GDM is an independent risk factor for adverse pregnancy outcomes and has a long-term impact on the health of both mothers and their offspring. The history of GDM can significantly increase the risk of type 2 diabetes mellitus (T2DM) in women,and although several risk factors have been identified,there is still a lack of early warning indicators for the progression to T2DM in patients with GDM. Therefore,it is urgently needed to discover novel biomarkers for predicting the risk of postpartum T2DM in GDM patients,thereby identifying the population at a high risk of diabetes as early as possible. In recent years,lipidomics,an important branch of metabolomics,has shown unique advantages in determining novel biomarkers for the risk of postpartum T2DM through high-throughput assessment of small-molecule lipid profile. This article systematically elaborates on the advances in the application of lipidomic techniques in the above field and summarizes the research findings of novel lipid-based biomarkers,in order to provide a theoretical framework for discovering intervention targets for GDM and developing precise treatment strategies based on lipidomics.
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Related Author
Zhang Shenrui
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Related Institution
Department of Endocrinology,Peking Union Medical College Hospital
Department of Endocrinology,Peking Union Medical College Hospital,Peking Union Medical College, Chinese Academy of Medical Sciences,Key Laboratory of Endocrinology of National Health Commission, Diabetes Research Center of Chinese Academy of Medical Sciences
Department of Endocrinology, The Hospital of PLA
Department of Endocrinology,Shenzhen Hospital(Futian) of Guangzhou University of Chinese Medicine
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