Value of <italic style="font-style: italic">Helicobacter</italic> <italic style="font-style: italic">pylori</italic> antibody typing combined with white light endoscopy technology in evaluating precancerous lesions of chronic atrophic gastritis

Shen Fei; Shen Tianben; Zang Lei; Xu Lili; Chu Wenfeng; Jin Tiandi; Bian Jieying; Qin Lucui

doi:10.13406/j.cnki.cyxb.003967

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Value of Helicobacter pylori antibody typing combined with white light endoscopy technology in evaluating precancerous lesions of chronic atrophic gastritis

Precision medicine in cancer and translational studies | 更新时间：2026-03-19

- Value of Helicobacter pylori antibody typing combined with white light endoscopy technology in evaluating precancerous lesions of chronic atrophic gastritis
- Journal of Chongqing Medical University Vol. 51, Issue 3, Pages: 353-361(2026)
- 作者机构：
  
  上海交通大学医学院附属新华医院消化内镜诊治部，上海 200092
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.003967
  CLC： R735.2
- Received：27 April 2025，
  
  Revised：2025-08-04，
  
  Accepted：10 August 2025，
  
  Published：28 March 2026
- 稿件说明：
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沈飞,沈天犇,臧蕾等.幽门螺杆菌感染抗体分型联合白光胃镜技术评估慢性萎缩性胃炎胃癌前病变的价值[J].重庆医科大学学报,2026,51(03):353-361.

Shen Fei,Shen Tianben,Zang Lei,et al.Value of Helicobacter pylori antibody typing combined with white light endoscopy technology in evaluating precancerous lesions of chronic atrophic gastritis[J].Journal of Chongqing Medical University,2026,51(03):353-361.
沈飞,沈天犇,臧蕾等.幽门螺杆菌感染抗体分型联合白光胃镜技术评估慢性萎缩性胃炎胃癌前病变的价值[J].重庆医科大学学报,2026,51(03):353-361. DOI： 10.13406/j.cnki.cyxb.003967.

Shen Fei,Shen Tianben,Zang Lei,et al.Value of Helicobacter pylori antibody typing combined with white light endoscopy technology in evaluating precancerous lesions of chronic atrophic gastritis[J].Journal of Chongqing Medical University,2026,51(03):353-361. DOI： 10.13406/j.cnki.cyxb.003967.

摘要

目的

探究幽门螺杆菌（helicobacter pylori，Hp）感染抗体分型联合白光胃镜技术评估慢性萎缩性胃炎（chronic atrophic gastritis，CAG）胃癌前病变的价值。

方法

选择2020年1月至2024年1月于本院收治的176例CAG患者作为研究对象，收集患者的胃镜检查、组织病理学检查以及Hp抗体测试的结果，探讨了胃镜下的分类及其细分类型、胃癌前病变严重程度、Hp感染状态以及Hp感染相关的抗体分型之间的关联性。采用外部验证队列（

=85）验证联合诊断的效能。

结果

176例患者中闭合型（C型）89例（50.57%），开放型（O型）87例（49.43%）。组织病理学显示无上皮内瘤变69.89%（123/176），低/高级别上皮内瘤变分别为15.91%（28/176）和11.36%（20/176），胃浸润癌2.84%（5/176）。Hp抗体阳性率为75.00%（132/176），其中Ⅰ型占50.57%（89/176）。从C1到O3亚型，胃癌前病变严重程度呈渐进性加重（

0.05）。Hp阳性（尤其I型）患者的病变程度显著重于阴性及Ⅱ型感染者（均

0.05）。受试者工作特征曲线分析表明，胃镜分型联合Hp分型诊断胃癌前病变严重程度的ROC曲线下面积、灵敏度和特异度均显著优于单一检测（外部验证

0.05）。

结论

胃镜分型、亚型与胃癌前病变严重程度呈正相关，Hp感染状态及抗体分型与胃癌前病变严重程度密切相关。开放型胃镜、Hp阳性及I型感染与更严重病变相关，且具有协同作用。胃镜分型联合Hp感染分型诊断胃癌前病变严重程度的灵敏度、特异度高于单独检测，可作为评估胃癌前病变的重要临床工具。

Abstract

Objective

To explore the value of using

Helicobacter

pylori

（Hp） antibody typing combined with white light endoscopy technology to evaluate precancerous lesions in chronic atrophic gastritis.

Methods

A total of 176 patients with chronic atrophic gastritis admitted to Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine between January 2020 and January 2024 were selected as the research subjects. The results of gastroscopy examination，histopathological examination，and Hp antibody testing were collected to explore the correlations of gastric atrophy classificat

ion and subtypes under gastroscopy，severity of precancerous lesions，Hp infection status，and Hp antibody typing. An external validation cohort（

=85） was used to verify the effectiveness of joint diagnosis.

Results

Among the 176 patients，89（50.57%） were classified as closed type（C type） and 87（49.43%） were classified as open type（O type）. Histopathological examination showed no intraepithelial neoplasia in 69.89%（123/176） of cases，low/high-grade intraepithelial neoplasia in 15.91%（28/176） and 11.36% （20/176） of cases，and gastric invasive carcinoma in 2.84%（5/176） of cases. The Hp antibody positivity rate was 75.00%（132/176），with type Ⅰaccounting for 50.57%（89/176）. From C1 to O3 subtypes，the severity of precancerous gastric lesions gradually increased（

0.05）. The severity of lesions in Hp-positive（especially type Ⅰ） patients was significantly greater than that in Hp-negative patients and those with type Ⅱ infection（both

0.05）. The area under the receiver operating characteristic curve，sensitivity，and specificity of gastroscopy-based classification combined with Hp typing for diagnosing the severity of precancerous gastric lesions were significantly superior to those of single detection methods （external validation

0.05）.

Conclusion

Gastroscopy-based classification and subtypes are positively correlated with the severity of precancerous gastric lesions，while Hp infection status and antibody typing are closely related to lesion severity. Open type，Hp positivity，and type I infection are associated with more severe lesions and have a synergistic effect. The sensitivity and specificity of gastroscopy-based classification combined with Hp typing in diagnosis of precancerous gastric lesion severity are higher than those of individual methods. This combined approach can be used as an important clinical tool for evaluating precancerous gastric lesions.

关键词

Keywords

references

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Value of Helicobacter pylori antibody typing combined with white light endoscopy technology in evaluating precancerous lesions of chronic atrophic gastritis

DOI：10.13406/j.cnki.cyxb.003967

摘要

Abstract

关键词

Keywords

references