1.中国医学科学院/北京协和医学院/北京协和医院内分泌科/国家卫生健康委员会内分泌重点实验室/ 中国医学科学院糖尿病研究中心,北京 100730
2.首都医科大学附属北京朝阳医院内分泌科,北京 100020
Received:09 July 2025,
Revised:2025-09-05,
Published:28 January 2026
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李舜华,周丽媛,任婧等.肠道菌群和DNA甲基化在生命早期运动对成年期糖脂代谢影响中的作用[J].重庆医科大学学报,2026,51(01):28-33.
Li Shunhua,Zhou Liyuan,Ren Jing,et al.The role of gut microbiota and DNA methylation in the effect of early-life exercise on glucolipid metabolism in adulthood[J].Journal of Chongqing Medical University,2026,51(01):28-33.
李舜华,周丽媛,任婧等.肠道菌群和DNA甲基化在生命早期运动对成年期糖脂代谢影响中的作用[J].重庆医科大学学报,2026,51(01):28-33. DOI: 10.13406/j.cnki.cyxb.003966.
Li Shunhua,Zhou Liyuan,Ren Jing,et al.The role of gut microbiota and DNA methylation in the effect of early-life exercise on glucolipid metabolism in adulthood[J].Journal of Chongqing Medical University,2026,51(01):28-33. DOI: 10.13406/j.cnki.cyxb.003966.
糖尿病和肥胖等慢性代谢性疾病目前已成为全球健康的巨大挑战。生命早期不良宫内环境明显增加成年期代谢性疾病的易感性。母代运动干预是改善后代糖脂代谢健康的有效措施,但具体机制不明。肠道菌群是该领域的研究热点。新近证据表明,肠菌源代谢物可通过提供甲基供体等方式参与宿主DNA甲基化。本综述旨在以“肠道菌群-肠菌源代谢物-DNA甲基化”视角解析生命早期运动干预的代际代谢保护效应,以期为在生命早期水平上阻断糖脂代谢紊乱的代际传递提供新的理论依据和潜在的干预靶点。
Chronic metabolic disorders such as diabetes and obesity have emerged as major global health challenges. Adverse intrauterine environment during early life significantly increases the susceptibility to metabolic diseases in adulthood. Maternal exercise intervention has been recognized as an effective measure to improve glucolipid metabolic health in offspring; however,the underlying mechanism remains unclear. Gut microbiota has become a research hotspot in this field. Recent evidence has shown that gut microbiota-derived metabolites may influence host DNA methylation by providing methyl donors. This article aims to clarify the protective effect of early-life exercise intervention on intergenerational metabolism from the perspective of the “gut microbiota-gut microbiota-derived metabolites-DNA methylation” axis,in order to provide new theoretical bases and potential intervention targets for disrupting the intergenerational transmission of glucolipid metabolic disorders.
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