1.河南中医药大学第一附属医院妇产科,郑州 450000
2.商丘市立医院创伤显微手足外科,商丘 476000
Received:28 June 2025,
Revised:2025-09-04,
Accepted:14 October 2025,
Published:28 May 2026
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赵倩倩,李淑荣,王丽娜等.铁死亡在妇产科疾病中的作用及机制研究进展[J].重庆医科大学学报,2026,51(05):741-750.
Zhao Qianqian,Li Shurong,Wang Lina,et al.Research advances in the role and mechanism of cell ferroptosis in obstetrical and gynecological diseases[J].Journal of Chongqing Medical University,2026,51(05):741-750.
赵倩倩,李淑荣,王丽娜等.铁死亡在妇产科疾病中的作用及机制研究进展[J].重庆医科大学学报,2026,51(05):741-750. DOI: 10.13406/j.cnki.cyxb.003965.
Zhao Qianqian,Li Shurong,Wang Lina,et al.Research advances in the role and mechanism of cell ferroptosis in obstetrical and gynecological diseases[J].Journal of Chongqing Medical University,2026,51(05):741-750. DOI: 10.13406/j.cnki.cyxb.003965.
铁死亡是一种铁依赖型的新型非凋亡性细胞程序性死亡,其特征是铁代谢紊乱、氧化还原障碍及脂质过氧化(lipid peroxidation,LPO)等,受到多种基因的调控。近年来研究证实,铁死亡与多种器官损伤密切相关,在疾病的发展和治疗反应中起着至关重要的作用,但其在妇产科疾病中的影响尚不明确,相关研究还很有限。故本文就常见妇产科疾病中铁死亡的关键性证据、特异性通路及铁死亡在其中的相关作用机制进行综述,以期为妇产科疾病的防治提供新见解,从而寻找治疗的新靶点和新策略。
Ferroptosis is a novel form of iron-dependent non-apoptotic programmed cell death characterized by iron metabolic disorders,redox disorders,and lipid peroxidation,and it is regulated by a variety of genes. In recent years,studies have confirmed that ferroptosis is closely associated with the injury of multiple organs and plays a crucial role in disease progression and therapeutic response; however,its impact on obstetrical and gynecological diseases remains unclear,with a limited number of studies. Therefore,this article reviews the key evidence of ferroptosis in common obstetrical and gynecological diseases,specific signaling pathways involved,and the mechanism of ferroptosis in these diseases,in order to provide new insights into the prevention and treatment of obstetrical and gynecological diseases and identify new therapeutic targets and strategies.
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