1.贵州医科大学口腔医学院,贵阳 550001
2.贵州医科大学附属口腔医院修复种植科,贵阳 550001
Received:16 February 2025,
Revised:2025-04-12,
Accepted:16 February 2025,
Published:28 October 2025
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袁怡婷,田艾.转录因子PU.1在炎症性疾病中的研究进展[J].重庆医科大学学报,2025,50(10):1392-1398.
Yuan Yiting,Tian Ai.Research advances in the transcription factor purine rich box-1 in inflammatory diseases[J].Journal of Chongqing Medical University,2025,50(10):1392-1398.
袁怡婷,田艾.转录因子PU.1在炎症性疾病中的研究进展[J].重庆医科大学学报,2025,50(10):1392-1398. DOI: 10.13406/j.cnki.cyxb.003922.
Yuan Yiting,Tian Ai.Research advances in the transcription factor purine rich box-1 in inflammatory diseases[J].Journal of Chongqing Medical University,2025,50(10):1392-1398. DOI: 10.13406/j.cnki.cyxb.003922.
炎症性疾病是由免疫系统异常激活引起的一类疾病,包括自身免疫性疾病、慢性炎症性肠病、代谢性炎症疾病和牙周炎等。转录因子富含嘌呤盒1(purine rich box-1,PU.1)通过调控免疫细胞的发育、分化及炎症信号通路,在炎症性疾病的发生发展过程中发挥重要作用。近年来,研究逐渐揭示PU.1在炎症反应中的核心作用,并突出了其作为潜在治疗靶点的临床应用价值。本文系统综述PU.1的生物学特征与调控机制,探讨其在炎症反应及常见炎症性疾病中的作用,并分析其临床应用策略,以期为未来研究及临床应用提供参考。
Inflammatory diseases are a group of disorders caused by abnormal activation of the immune system,including autoimmune diseases,chronic inflammatory bowel disease,metabolic inflammatory diseases,and periodontitis. The transcription factor purine rich box-1(PU.1) plays an important role in the development and progression of inflammatory diseases by regulating the development and differentiation of immune cells and related inflammatory signaling pathways. In recent years,studies have gradually revealed the central role of PU.1 in inflammatory response and highlighted its clinical application value as a potential therapeutic target. This article systematically summarizes the biological features and regulatory mechanisms of PU.1,explores its role in inflammatory response and common inflammatory diseases,and analyzes its clinical application strategies,in order to provide a reference for future research and clinical application.
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