广州中医药大学深圳医院(福田)内分泌科室,深圳 518000
Received:12 March 2025,
Revised:2025-06-10,
Accepted:20 June 2025,
Published:28 October 2025
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陈家祈,徐菁晗,刘添娇,等.2型糖尿病患者合并阻塞性睡眠呼吸暂停的研究进展[J].重庆医科大学学报,2025,50(10):1309-1316.
Chen Jiaqi,Xu Jinghan,Liu Tianjiao,et al.Research advances in type 2 diabetes mellitus with obstructive sleep apnea[J].Journal of Chongqing Medical University,2025,50(10):1309-1316.
陈家祈,徐菁晗,刘添娇,等.2型糖尿病患者合并阻塞性睡眠呼吸暂停的研究进展[J].重庆医科大学学报,2025,50(10):1309-1316. DOI: 10.13406/j.cnki.cyxb.003918.
Chen Jiaqi,Xu Jinghan,Liu Tianjiao,et al.Research advances in type 2 diabetes mellitus with obstructive sleep apnea[J].Journal of Chongqing Medical University,2025,50(10):1309-1316. DOI: 10.13406/j.cnki.cyxb.003918.
随着肥胖人群的增长及人口老龄化,2型糖尿病(type 2 diabetes mellitus,T2DM)及阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)的发病率不断上升,超过五成的T2DM患者合并OSA。合并OSA的T2DM患者有较高的大血管、微血管并发症的发病风险,严重危害患者的生活质量,尽早识别合并OSA的T2DM患者可改善其预后。本文总结了T2DM合并OSA的病理机制、生物标志物和治疗措施的最新研究进展,为T2DM合并OSA的筛查和诊疗提供思路。
With the increase in the obese population and the aging of the society,the incidence rates of type 2 diabetes mellitus (T2DM) and obstructive sleep apnea(OSA) continue to increase,and more than half of the patients with T2DM also suffer from OSA. T2DM patients with OSA have a higher risk of developing macrovascular and microvascular complications,which severely impairs their quality of life,and early identification of T2DM patients with OSA can improve their prognosis. This article summarizes the latest research advances in the pathogenesis,biomarkers,and treatment measures of T2DM with OSA,in order to provide insights for the screening,diagnosis,and treatment of T2DM with OSA.
Kapur VK , Auckley DH , Chowdhuri S , et al . Clinical practice guideline for diagnostic testing for adult obstructive sleep apnea:an American academy of sleep medicine clinical practice guideline [J ] . J Clin Sleep Med , 2017 , 13 ( 3 ): 479 - 504 .
Fallahi A , Jamil DI , Karimi EB , et al . Prevalence of obstructive sleep apnea in patients with type 2 diabetes:a systematic review and meta-analysis [J ] . Diabetes Metab Syndr , 2019 , 13 ( 4 ): 2463 - 2468 .
Zhang PH , Zhang R , Zhao F , et al . The prevalence and characteristics of obstructive sleep apnea in hospitalized patients with type 2 diabetes in China [J ] . J Sleep Res , 2016 , 25 ( 1 ): 39 - 46 .
Foster GD , Sanders MH , Millman R , et al . Obstructive sleep apnea among obese patients with type 2 diabetes [J ] . Diabetes Care , 2009 , 32 ( 6 ): 1017 - 1019 .
Chen ST , Wang JL , Wang JP , et al . Obesity as a mediator linking sleep-disordered breathing to both impaired fasting glucose and type 2 diabetes [J ] . Sleep Breath , 2023 , 27 ( 3 ): 1067 - 1080 .
Labarca G , Dreyse J , Salas C , et al . Risk of mortality among patients with moderate to severe obstructive sleep apnea and diabetes mellitus:results from the SantOSA cohort [J ] . Sleep Breath , 2021 , 25 ( 3 ): 1467 - 1475 .
Tahrani AA , Ali A , Raymond NT , et al . Obstructive sleep apnea and diabetic nephropathy:a cohort study [J ] . Diabetes Care , 2013 , 36 ( 11 ): 3718 - 3725 .
Altaf QA , Dodson P , Ali A , et al . Obstructive sleep apnea and retinopathy in patients with type 2 diabetes. a longitudinal study [J ] . Am J Respir Crit Care Med , 2017 , 196 ( 7 ): 892 - 900 .
Tahrani AA , Ali A , Raymond NT , et al . Obstructive sleep apnea and diabetic neuropathy:a novel association in patients with type 2 diabetes [J ] . Am J Respir Crit Care Med , 2012 , 186 ( 5 ): 434 - 441 .
Uchiyama T , Ota H , Ohbayashi C , et al . Effects of intermittent hypoxia on cytokine expression involved in insulin resistance [J ] . Int J Mol Sci , 2021 , 22 ( 23 ): 12898 .
Hursel R , Rutters F , Gonnissen HKJ , et al . Effects of sleep fragmentation in healthy men on energy expenditure,substrate oxidation,physical activity,and exhaustion measured over 48 h in a respiratory chamber [J ] . Am J Clin Nutr , 2011 , 94 ( 3 ): 804 - 808 .
Avogaro A , Toffolo G , Valerio A , et al . Epinephrine exerts opposite effects on peripheral glucose disposal and glucose-stimulated insulin secretion. A stable label intravenous glucose tolerance test minimal model study [J ] . Diabetes , 1996 , 45 ( 10 ): 1373 - 1378 .
Nonogaki K . New insights into sympathetic regulation of glucose and fat metabolism [J ] . Diabetologia , 2000 , 43 ( 5 ): 533 - 549 .
Kumar GK , Rai V , Sharma SD , et al . Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress [J ] . J Physiol , 2006 , 575 ( Pt 1 ): 229 - 239 .
Farías JG , Herrera EA , Carrasco-Pozo C , et al . Pharmacological models and approaches for pathophysiological conditions associated with hypoxia and oxidative stress [J ] . Pharmacol Ther , 2016 , 158 : 1 - 23 .
Zeng S , Wang YY , Ai L , et al . Chronic intermittent hypoxia-induced oxidative stress activates TRB3 and phosphorylated JNK to mediate insulin resistance and cell apoptosis in the pancreas [J ] . Clin Exp Pharmacol Physiol , 2024 , 51 ( 3 ): e13843 .
Kim S , Whelan J , Claycombe K , et al . Angiotensin II increases leptin secretion by 3T3-L1 and human adipocytes via a prostaglandin-independent mechanism [J ] . J Nutr , 2002 , 132 ( 6 ): 1135 - 1140 .
Berger S , Polotsky VY . Leptin and leptin resistance in the pathogenesis of obstructive sleep apnea:a possible link to oxidative stress and cardiovascular complications [J ] . Oxid Med Cell Longev , 2018 , 2018 : 5137947 .
He Q , Yang QC , Zhou Q , et al . Effects of varying degrees of intermittent hypoxia on proinflammatory cytokines and adipokines in rats and 3T3-L1 adipocytes [J ] . PLoS One , 2014 , 9 ( 1 ): e86326 .
Yamamoto Y , Fujiuchi S , Hiramatsu M , et al . Resistin is closely related to systemic inflammation in obstructive sleep apnea [J ] . Respiration , 2008 , 76 ( 4 ): 377 - 385 .
Hu ZP , Deng HC , Qu H . Plasma SFRP5 levels are decreased in Chinese subjects with obesity and type 2 diabetes and negatively correlated with parameters of insulin resistance [J ] . Diabetes Res Clin Pract , 2013 , 99 ( 3 ): 391 - 395 .
Chopra S , Rathore A , Younas H , et al . Obstructive sleep apnea dynamically increases nocturnal plasma free fatty acids,glucose,and cortisol during sleep [J ] . J Clin Endocrinol Metab , 2017 , 102 ( 9 ): 3172 - 3181 .
Antomagesh F , Rajeswari JJ , Vijayan MM . Chronic Cortisol elevation restricts glucose uptake but not insulin responsiveness in zebrafish skeletal muscle [J ] . Gen Comp Endocrinol , 2023 , 336 : 114231 .
Díaz-García E , García-Tovar S , Alfaro E , et al . Inflammasome activation:a keystone of proinflammatory response in obstructive sleep apnea [J ] . Am J Respir Crit Care Med , 2022 , 205 ( 11 ): 1337 - 1348 .
Zhao L , Liu Y , Wang XR . TNF-α promotes insulin resistance in obstructive sleep apnea-hypopnea syndrome [J ] . Exp Ther Med , 2021 , 21 ( 6 ): 568 .
Keller T , Hader C , De Zeeuw J , et al . Obstructive sleep apnea syndrome:the effect of diabetes and autonomic neuropathy [J ] . J Physiol Pharmacol , 2007 , 58 Suppl 5 : S313 - S318 .
Baum P , Toyka KV , Blüher M , et al . Inflammatory mechanisms in the pathophysiology of diabetic peripheral neuropathy (DN)-new aspects [J ] . Int J Mol Sci , 2021 , 22 ( 19 ): 10835 .
Wu XD , Chen KY , Williams KJ . The role of pathway-selective insulin resistance and responsiveness in diabetic dyslipoproteinemia [J ] . Curr Opin Lipidol , 2012 , 23 ( 4 ): 334 - 344 .
Yazıcı D , Sezer H . Insulin resistance,obesity and lipotoxicity [J ] . Adv Exp Med Biol , 2017 , 960 : 277 - 304 .
Chen LG , Chen XW , Huang X , et al . Regulation of glucose and lipid metabolism in health and disease [J ] . Sci China Life Sci , 2019 , 62 ( 11 ): 1420 - 1458 .
Glass CK , Olefsky JM . Inflammation and lipid signaling in the etiology of insulin resistance [J ] . Cell Metab , 2012 , 15 ( 5 ): 635 - 645 .
Wu LY , Parhofer KG . Diabetic dyslipidemia [J ] . Metabolism , 2014 , 63 ( 12 ): 1469 - 1479 .
Adedayo AM , Olafiranye O , Smith D , et al . Obstructive sleep apnea and dyslipidemia:evidence and underlying mechanism [J ] . Sleep Breath , 2014 , 18 ( 1 ): 13 - 18 .
Bahiru E , Hsiao R , Phillipson D , et al . Mechanisms and treatment of dyslipidemia in diabetes [J ] . Curr Cardiol Rep , 2021 , 23 ( 4 ): 26 .
Yan SF , Ramasamy R , Schmidt AM . The RAGE axis:a fundamental mechanism signaling danger to the vulnerable vasculature [J ] . Circ Res , 2010 , 106 ( 5 ): 842 - 853 .
Cook S , Scherrer U . Insulin resistance,a new target for nitric oxide-delivery drugs [J ] . Fundam Clin Pharmacol , 2002 , 16 ( 6 ): 441 - 453 .
da Silva AA , do Carmo JM , Li X , et al . Role of hyperinsulinemia and insulin resistance in hypertension:metabolic syndrome revisited [J ] . Can J Cardiol , 2020 , 36 ( 5 ): 671 - 682 .
Zhou MS , Schulman IH , Raij L . Vascular inflammation,insulin resistance,and endothelial dysfunction in salt-sensitive hypertension:role of nuclear factor kappa B activation [J ] . J Hypertens , 2010 , 28 ( 3 ): 527 - 535 .
Wang Y , Li CX , Lin YN , et al . The role of aldosterone in OSA and OSA-related hypertension [J ] . Front Endocrinol(Lausanne) , 2022 , 12 : 801689 .
Prabhakar NR , Peng YJ , Nanduri J . Hypoxia-inducible factors and obstructive sleep apnea [J ] . J Clin Invest , 2020 , 130 ( 10 ): 5042 - 5051 .
刘盈睿 , 王嘉仪 , 王业沣 , 等 . 糖皮质激素诱导转录物1在糖尿病小鼠认知功能障碍中的作用及机制 [J ] . 中山大学学报(医学科学版) , 2025 , 46 ( 5 ): 826 - 835 .
Liu YR , Wang JY , Wang YF , et al . Role and mechanism of glucocorti-coid-induced transcript 1 in cognitive dysfunction of diabetic mice [J ] . J Sun Yat Sen Univ Med Sci , 2025 , 46 ( 5 ): 826 - 835 .
Sun L , Liu JY , Li LR . Serum YKL-40 levels are associated with type 2 diabetes mellitus in patients with obstructive sleep apnea syndrome [J ] . Genet Mol Res , 2015 , 14 ( 3 ): 8919 - 8925 .
Fleming WE , Holty JC , Bogan RK , et al . Use of blood biomarkers to screen for obstructive sleep apnea [J ] . Nat Sci Sleep , 2018 , 10 : 159 - 167 .
李 影 , 郑玉龙 , 万玉峰 , 等 . 唾液酸、C反应蛋白对阻塞型睡眠呼吸暂停低通气综合征合并2型糖尿病的影响 [J ] . 中国现代医学杂志 , 2022 , 32 ( 5 ): 75 - 79 .
Li Y , Zheng YL , Wan YF , et al . Effect of serum sialic acid and C-reactive protein on patients with obstructive sleep apnea syndrome and type 2 diabetes mellitus [J ] . China J Mod Med , 2022 , 32 ( 5 ): 75 - 79 .
汪书琴 , 胡 涛 . 2型糖尿病合并阻塞性睡眠呼吸暂停低通气综合征患者Sestrin2、NLR、PLR水平变化及与胰岛素抵抗的相关性 [J ] . 中国现代医药杂志 , 2023 , 25 ( 2 ): 20 - 25 .
Wang SQ , Hu T . Correlation between serum Sestrin2,NLR,PLR levels and insulin resistance in type 2 diabetes mellitus with obstructive sleep apnea hypopnea syndrome patients [J ] . Mod Med J China , 2023 , 25 ( 2 ): 20 - 25 .
Gong LN , Wang ZZ , Wang ZG , et al . Sestrin2 as a potential target for regulating metabolic-related diseases [J ] . Front Endocrinol(Lausanne) , 2021 , 12 : 751020 .
El-Gazzar AG , Kamel MH , Elbahnasy OKM , et al . Prognostic value of platelet and neutrophil to lymphocyte ratio in COPD patients [J ] . Expert Rev Respir Med , 2020 , 14 ( 1 ): 111 - 116 .
龚淑兰 , 吕 晔 , 王琳 . 2型糖尿病并阻塞性睡眠呼吸暂停综合征与炎症相关性研究分析 [J ] . 中外医疗 , 2023 , 42 ( 14 ): 5 - 8 .
Gong SL , Lü Y , Wang L . Correlation between type 2 diabetes mellitus and obstructive sleep apnea syndrome and inflammation [J ] . China Foreign Med Treat , 2023 , 42 ( 14 ): 5 - 8 .
Guo Q , Wang Y , Li QY , et al . Levels of thioredoxin are related to the severity of obstructive sleep apnea:based on oxidative stress concept [J ] . Sleep Breath , 2013 , 17 ( 1 ): 311 - 316 .
曹 冰 , 王 莉 , 邢钰敏 , 等 . 2型糖尿病患者血清鸢尾素、摄食抑制因子-1、3-硝基酪氨酸水平与糖脂代谢和阻塞性睡眠呼吸暂停低通气综合征的关系研究 [J ] . 现代生物医学进展 , 2022 , 22 ( 20 ): 3887 - 3891,3907 .
Cao B , Wang L , Xing YM , et al . Relationship study between serum irisin,nesfatin-1 and 3-nitrotyrosine levels in patients with type 2 diabetes mellitus and glucose and lipid metabolism and obstructive sleep apnea hypopnea syndrome [J ] . Prog Mod Biomed , 2022 , 22 ( 20 ): 3887 - 3891,3907 .
Kanbay A , Ceylan E , Köseoğlu Hİ , et al . Endocan:a novel predictor of endothelial dysfunction in obstructive sleep apnea syndrome [J ] . Clin Respir J , 2018 , 12 ( 1 ): 84 - 90 .
Klisic A , Kavaric N , Stanisic V , et al . Endocan and a novel score for dyslipidemia,oxidative stress and inflammation(DOI score) are independently correlated with glycated hemoglobin(HbA 1c ) in patients with prediabetes and type 2 diabetes [J ] . Arch Med Sci , 2019 , 16 ( 1 ): 42 - 50 .
侯玮琼 , 杨勋超 , 姜 北 , 等 . 2型糖尿病合并OSAS患者AHI与血管损伤标志物的相关性 [J ] . 安徽医学 , 2022 , 43 ( 10 ): 1157 - 1161 .
Hou WQ , Yang XC , Jiang B , et al . Correlation between AHI and vascular injury markers in patients with type 2 diabetes mellitus complicated with OSAS [J ] . Anhui Med J , 2022 , 43 ( 10 ): 1157 - 1161 .
Perakakis N , Triantafyllou GA , Fernández-Real JM , et al . Physiology and role of irisin in glucose homeostasis [J ] . Nat Rev Endocrinol , 2017 , 13 ( 6 ): 324 - 337 .
Cowan E , Burch KJ , Green BD , et al . Obestatin as a key regulator of metabolism and cardiovascular function with emerging therapeutic potential for diabetes [J ] . Br J Pharmacol , 2016 , 173 ( 14 ): 2165 - 2181 .
Liu Y , Chen X , Qu Y , et al . Central nesfatin-1 activates lipid mobilization in adipose tissue and fatty acid oxidation in muscle via the sympathetic nervous system [J ] . Biofactors , 2020 , 46 ( 3 ): 454 - 464 .
Buechler C , Feder S , Haberl EM , et al . Chemerin isoforms and activity in obesity [J ] . Int J Mol Sci , 2019 , 20 ( 5 ): 1128 .
刘亚男 , 何 宁 , 勾璇 . 2型糖尿病合并阻塞性睡眠呼吸暂停低通气综合征患者血清Chemerin、Nesfatin-1、Obestatin的检测水平及意义 [J ] . 临床和实验医学杂志 , 2021 , 20 ( 24 ): 2614 - 2617 .
Liu YN , He N , Gou X . Detection levels and significance of serum Chemerin,Nesfatin-1 and Obestatin in patients with type 2 diabetes mellitus complicated obstructive sleep apnea hypopnea syndrome [J ] . J Clin Exp Med , 2021 , 20 ( 24 ): 2614 - 2617 .
Uchiyama T , Ota H , Itaya-Hironaka A , et al . Up-regulation of selenoprotein P and HIP/PAP mRNAs in hepatocytes by intermittent hypoxia via down-regulation of miR-203 [J ] . Biochem Biophys Rep , 2017 , 11 : 130 - 137 .
Takasawa S , Shobatake R , Itaya-Hironaka A , et al . Upregulation of IL-8,osteonectin,and myonectin mRNAs by intermittent hypoxia via OCT1- and NRF2-mediated mechanisms in skeletal muscle cells [J ] . J Cell Mol Med , 2022 , 26 ( 24 ): 6019 - 6031 .
Uchiyama T , Itaya-Hironaka A , Yamauchi A , et al . Intermittent hypoxia up-regulates CCL2 , RETN, and TNFα mRNAs in adipocytes via down-regulation of miR-452 [J ] . Int J Mol Sci , 2019 , 20 ( 8 ): 1960 .
林浩辉 , 苏杰 , 郑伟强 , 等 . 基于miRNA-24表达探讨阻塞性睡眠呼吸暂停综合征患者胰岛β细胞功能受损状况的研究 [J ] . 江西医药 , 2021 , 56 ( 9 ): 1358 - 1361 .
Lin HH , Su J , Zheng WQ , et al . A study on the impairment of pancreatic βcell function in patients with obstructive sleep apnea syndrome based on miRNA-24 expression [J ] . Jiangxi Med J , 2021 , 56 ( 9 ): 1358 - 1361 .
何金花 , 刘丹枫 , 高丽娟 , 等 . 2型糖尿病合并OSAHS患者miR-34a、SIRT1水平的检测及意义 [J ] . 国际检验医学杂志 , 2021 , 42 ( 8 ): 1006 - 1009 .
He JH , Liu DF , Gao LJ , et al . Detection and significance of miR-34a and SIRT1 levels in patients with type 2 diabetes mellitus combined with OSAHS [J ] . Int J Lab Med , 2021 , 42 ( 8 ): 1006 - 1009 .
Xu HJ , Zheng XJ , Qian YJ , et al . Metabolomics profiling for obstructive sleep apnea and simple snorers [J ] . Sci Rep , 2016 , 6 : 30958 .
Lebkuchen A , Carvalho VM , Venturini G , et al . Metabolomic and lipidomic profile in men with obstructive sleep apnoea:implications for diagnosis and biomarkers of cardiovascular risk [J ] . Sci Rep , 2018 , 8 ( 1 ): 11270 .
Tang SS , Liang CH , Liu YL , et al . Intermittent hypoxia is involved in gut microbial dysbiosis in type 2 diabetes mellitus and obstructive sleep apnea-hypopnea syndrome [J ] . World J Gastroenterol , 2022 , 28 ( 21 ): 2320 - 2333 .
Ko CY , Fan JM , Hu AK , et al . Disruption of sleep architecture in Prevotella enterotype of patients with obstructive sleep apnea-hypopnea syndrome [J ] . Brain Behav , 2019 , 9 ( 5 ): e01287 .
Aron-Wisnewsky J , Vigliotti C , Witjes J , et al . Gut microbiota and human NAFLD:disentangling microbial signatures from metabolic disorders [J ] . Nat Rev Gastroenterol Hepatol , 2020 , 17 ( 5 ): 279 - 297 .
Herth J , Sievi NA , Schmidt F , et al . Effects of continuous positive airway pressure therapy on glucose metabolism in patients with obstructive sleep apnoea and type 2 diabetes:a systematic review and meta-analysis [J ] . Eur Respir Rev , 2023 , 32 ( 169 ): 230083 .
Labarca G , Reyes T , Jorquera J , et al . CPAP in patients with obstructive sleep apnea and type 2 diabetes mellitus:Systematic review and meta-analysis [J ] . Clin Respir J , 2018 , 12 ( 8 ): 2361 - 2368 .
Veasey SC , Rosen IM . Obstructive sleep apnea in adults [J ] . N Engl J Med , 2019 , 380 ( 15 ): 1442 - 1449 .
Lam JCM , Lai AYK , Tam TCC , et al . CPAP therapy for patients with sleep apnea and type 2 diabetes mellitus improves control of blood pressure [J ] . Sleep Breath , 2017 , 21 ( 2 ): 377 - 386 .
Myhill PC , Davis WA , Peters KE , et al . Effect of continuous positive airway pressure therapy on cardiovascular risk factors in patients with type 2 diabetes and obstructive sleep apnea [J ] . J Clin Endocrinol Metab , 2012 , 97 ( 11 ): 4212 - 4218 .
Gasa M , Tamisier R , Launois SH , et al . Residual sleepiness in sleep apnea patients treated by continuous positive airway pressure [J ] . J Sleep Res , 2013 , 22 ( 4 ): 389 - 397 .
Baslas V , Chand P , Jurel SK , et al . A pilot study to determine the effect of three months of oral appliance therapy using a mandibular advancement device on HbA1c in subjects with type 2 diabetes mellitus and obstructive sleep apnea [J ] . J Prosthodont , 2019 , 28 ( 3 ): 271 - 275 .
Quah B , Sng TJH , Yong CW , et al . Orthognathic surgery for obstructive sleep apnea [J ] . Oral Maxillofac Surg Clin North Am , 2023 , 35 ( 1 ): 49 - 59 .
Peppard PE , Young T , Palta M , et al . Longitudinal study of moderate weight change and sleep-disordered breathing [J ] . JAMA , 2000 , 284 ( 23 ): 3015 - 3021 .
Newman AB , Foster G , Givelber R , et al . Progression and regression of sleep-disordered breathing with changes in weight:the Sleep Heart Health Study [J ] . Arch Intern Med , 2005 , 165 ( 20 ): 2408 - 2413 .
Shechter A , Foster GD , Lang W , et al . Effects of a lifestyle intervention on REM sleep-related OSA severity in obese individuals with type 2 diabetes [J ] . J Sleep Res , 2017 , 26 ( 6 ): 747 - 755 .
Sawada K , Karashima S , Kometani M , et al . Effect of sodium glucose cotransporter 2 inhibitors on obstructive sleep apnea in patients with type 2 diabetes [J ] . Endocr J , 2018 , 65 ( 4 ): 461 - 467 .
Furukawa S , Miyake T , Senba H , et al . The effectiveness of dapagliflozin for sleep-disordered breathing among Japanese patients with obesity and type 2 diabetes mellitus [J ] . Endocr J , 2018 , 65 ( 9 ): 953 - 961 .
Tang Y , Sun Q , Bai XY , et al . Effect of dapagliflozin on obstructive sleep apnea in patients with type 2 diabetes:a preliminary study [J ] . Nutr Diabetes , 2019 , 9 ( 1 ): 32 .
Kusunoki M , Hisano F , Wakazono N , et al . Effect of treatment with sodium-glucose cotransporter 2 inhibitor on the initiation of continuous positive airway pressure therapy in type 2 diabetic patients with obstructive sleep apnea syndrome [J ] . J Clin Med Res , 2021 , 13 ( 10/11 ): 497 - 501 .
Kow CS , Ramachandram DS , Hasan SS , et al . Efficacy and safety of GLP-1 receptor agonists in the management of obstructive sleep apnea in individuals without diabetes:a systematic review and meta-analysis of randomized,placebo-controlled trials [J ] . Sleep Med , 2025 , 129 : 40 - 44 .
Jiang WL , Li WG , Cheng J , et al . Efficacy and safety of liraglutide in patients with type 2 diabetes mellitus and severe obstructive sleep apnea [J ] . Sleep Breath , 2023 , 27 ( 5 ): 1687 - 1694 .
Zunica ERM , Heintz EC , Dantas WS , et al . Effects of metformin on glucose metabolism and mitochondrial function in patients with obstructive sleep apnea:a pilot randomized trial [J ] . Physiol Rep , 2024 , 12 ( 3 ): e15948 .
王晓依 , 张 桢 , 韩洁 , 等 . 卡格列净联合德谷胰岛素利拉鲁肽、吡格列酮二甲双胍治疗肥胖T2DM效果及对胰岛素敏感性影响 [J ] . 中华内分泌外科杂志 , 2024 , 18 ( 5 ): 728 - 732 .
Wang XY , Zhang Z , Han J , et al . Effect of cagglinide combined with degulin liraglutide and pioglitazone metformin on obese T2DM and its influence on insulin sensitivity [J ] . Chin J Endocr Surg , 2024 , 18 ( 5 ): 728 - 732 .
卢 琳 , 何 杰 , 李培培 , 等 . 达格列净联合二甲双胍治疗肥胖2型糖尿病合并OSAS疗效及安全性的Meta分析 [J ] . 疑难病杂志 , 2020 , 19 ( 8 ): 778 - 784 .
Lu L , He J , Li PP , et al . Meta-analysis of efficacy and safety of dapagliflozin combined with metformin in the treatment of obese type 2 diabetes mellitus with obstructive sleep apnea syndrome [J ] . Chin J Difficult Complicat Cases , 2020 , 19 ( 8 ): 778 - 784 .
常红叶 , 徐晓静 , 杨爱霞 , 等 . 二甲双胍联合贝那鲁肽治疗阻塞性睡眠呼吸暂停综合征合并2型糖尿病临床疗效 [J ] . 中国现代医药杂志 , 2021 , 23 ( 5 ): 41 - 43 .
Chang HY , Xu XJ , Yang AX , et al . Clinical efficacy of metformin combined with benadrutide in the treatment of obstructive sleep apnea syndrome complicated with type 2 diabetes mellitus [J ] . Mod Med J China , 2021 , 23 ( 5 ): 41 - 43 .
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