陆军军医大学大坪医院肿瘤科,重庆 400042
Received:01 February 2025,
Revised:2025-06-16,
Published:28 January 2026
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杜佳,李梦侠,陈川.放疗联合免疫治疗驱动基因阴性非小细胞肺癌:进展与挑战[J].重庆医科大学学报,2026,51(01):66-72.
Du Jia,Li Mengxia,Chen Chuan.Radiotherapy combined with immunotherapy in treatment of driver gene-negative non-small cell lung cancer: updates and challenges[J].Journal of Chongqing Medical University,2026,51(01):66-72.
杜佳,李梦侠,陈川.放疗联合免疫治疗驱动基因阴性非小细胞肺癌:进展与挑战[J].重庆医科大学学报,2026,51(01):66-72. DOI: 10.13406/j.cnki.cyxb.003903.
Du Jia,Li Mengxia,Chen Chuan.Radiotherapy combined with immunotherapy in treatment of driver gene-negative non-small cell lung cancer: updates and challenges[J].Journal of Chongqing Medical University,2026,51(01):66-72. DOI: 10.13406/j.cnki.cyxb.003903.
非小细胞肺癌(non-small cell lung cancer,NSCLC)是肺癌中最常见的类型,约占原发肺癌病例的85%。而驱动基因阴性NSCLC常面临治疗选择有限的困境。近年来,放疗与免疫治疗的联合成为驱动基因阴性NSCLC新的治疗策略之一,显示出改善生存率和提高疗效的潜力。本文综述了放疗联合免疫治疗的生物学机制以及在驱动基因阴性NSCLC中的临床应用,并探讨了其面临的挑战,以期为临床实践提供参考。
Non-small cell lung cancer(NSCLC),as the most common type of lung cancer,accounts for approximately 85% of primary lung cancer cases,while there are often limited treatment options for driver gene-negative NSCLC. In recent years,the combination of radiotherapy and immunotherapy has emerged as a novel treatment strategy for driver gene-negative NSCLC,demonstrating the potential to improve survival rates and treatment outcomes. This article reviews the biological mechanisms of radiotherapy combined with immunotherapy and the clinical application of this method in driver gene-negative NSCLC and discusses related challenges,in order to provide a reference for clinical practice.
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