Application of different surgical approaches in interval debulking surgery for advanced ovarian cancer: a comparative analysis

Wu Yingyu; Wu Jialin; Xiao Lin; Tang Yujie; Shang Xiaojuan

doi:10.13406/j.cnki.cyxb.003902

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Application of different surgical approaches in interval debulking surgery for advanced ovarian cancer: a comparative analysis

Excellence in medical insights\: surgical robots and robotic surgery | 更新时间：2026-03-19

- Application of different surgical approaches in interval debulking surgery for advanced ovarian cancer: a comparative analysis
- Journal of Chongqing Medical University Vol. 51, Issue 3, Pages: 323-330(2026)
- 作者机构：
  
  重庆医科大学附属第一医院妇科，重庆 400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.003902
  CLC： R737
- Received：13 January 2025，
  
  Revised：2025-04-19，
  
  Accepted：28 April 2025，
  
  Published：28 March 2026
- 稿件说明：
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伍硬语,武加林,肖琳等.不同手术方式在晚期卵巢癌中间型肿瘤细胞减灭术中的应用对比研究[J].重庆医科大学学报,2026,51(03):323-330.

Wu Yingyu,Wu Jialin,Xiao Lin,et al.Application of different surgical approaches in interval debulking surgery for advanced ovarian cancer: a comparative analysis[J].Journal of Chongqing Medical University,2026,51(03):323-330.
伍硬语,武加林,肖琳等.不同手术方式在晚期卵巢癌中间型肿瘤细胞减灭术中的应用对比研究[J].重庆医科大学学报,2026,51(03):323-330. DOI： 10.13406/j.cnki.cyxb.003902.

Wu Yingyu,Wu Jialin,Xiao Lin,et al.Application of different surgical approaches in interval debulking surgery for advanced ovarian cancer: a comparative analysis[J].Journal of Chongqing Medical University,2026,51(03):323-330. DOI： 10.13406/j.cnki.cyxb.003902.

摘要

目的

比较机器人手术、腹腔镜手术和开腹手术在晚期卵巢癌中间型肿瘤细胞减瘤术中减瘤结局和生存预后的差异及影响因素。

方法

回顾性收集2017年1月至2023年6月在重庆医科大学附属第一医院接受中间型肿瘤细胞减灭术的158例Ⅲ/Ⅳ期卵巢癌患者的临床资料，纳入患者分为机器人组、腹腔镜组和开腹组，评估组间临床特征、手术结果和预后生存的差异。

结果

尽管组间的手术减瘤结局没有显著差异，但与腹腔镜和开腹手术相比，机器人手术表现出更短的手术时间（

0.001），更少的手术出血量（

0.001）和更低的围术期输血率（

=0.008）。机器人组的中位无进展生存期（progression-free survival，PFS）明显更长（

=0.032），而3组间总体生存时间差异无统计学意义（

=0.229）。多因素分析显示术前CA125水平是无进展生存时间的独立预后因素。

结论

机器人手术治疗晚期卵巢癌的围术期优于传统腹腔镜和开腹手术，特别是手术时间、出血量和输血率方面。更长的无进展生存时间可能归因于较低的肿瘤负荷，对于肿瘤负荷较低、对化疗反应良好的患者，机器人手术是一种可行的选择。

Abstract

Objective

To investigate the differences between robotic surgery，laparoscopic surgery，and laparotomy in cytoreduction outcomes and survival prognosis in interval debulking surgery for advanced ovarian cancer and related influencing factors.

Methods

A retrospective analysis was performed for the clinical data of 158 patients with stage Ⅲ/Ⅳ ovarian cancer who underwent interval debulking surgery in The First Affiliated Hospital of Chongqing Medical University from January 2017 to June 2023，and the patients were divided into robotic surgery group，laparoscopic surgery group，and laparotomy group. The three groups were compared in terms of clinical features，surgical outcomes，and survival prognosis.

Results

Although there was no significant difference in cytoreduction outcomes between groups，compared with the laparoscopic surgery group and the laparotomy group，the robotic surgery group had a significantly shorter time of operation（

0.001），a significantly lower intraoperative blood loss（

0.001），and a significantly lower perioperative transfusion rate（

=0.008）. The robotic surgery group had a significantly longer progression-free survival（

=0.032），while there was no significant difference in overall survival between the three groups（

=0.229）. The multivariate analysis showed that preoperative CA125 was an independent prognostic factor for progression-free survival.

Conclusion

In the treatment of advanced ovarian cancer，robotic surgery is superior to laparoscopic surgery and laparotomy in the perioperative period，especially in the aspects of time of operation，blood loss，and transfusion rate. A longer progression-free survival may be attributed to a lower tumor burden，and robotic surgery might be a feasible surgical approach for patients with a low tumor burden and good response to chemotherapy.

关键词

Keywords

references

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