复旦大学附属妇产科医院产科,上海 200090
Received:23 April 2025,
Revised:2025-05-12,
Accepted:19 May 2025,
Published:28 September 2025
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张潇月,刘真真,裴江南,等.乳酸脱氢酶:子痫前期的潜在调控因子[J].重庆医科大学学报,2025,50(9):1242-1246.
Zhang Xiaoyue,Liu Zhenzhen,Pei Jiangnan,et al.Lactate dehydrogenase: a potential regulatory molecule in preeclampsia[J].Journal of Chongqing Medical University,2025,50(9):1242-1246.
张潇月,刘真真,裴江南,等.乳酸脱氢酶:子痫前期的潜在调控因子[J].重庆医科大学学报,2025,50(9):1242-1246. DOI: 10.13406/j.cnki.cyxb.003875.
Zhang Xiaoyue,Liu Zhenzhen,Pei Jiangnan,et al.Lactate dehydrogenase: a potential regulatory molecule in preeclampsia[J].Journal of Chongqing Medical University,2025,50(9):1242-1246. DOI: 10.13406/j.cnki.cyxb.003875.
子痫前期(pre-eclampsia,PE)是一种严重威胁母婴安全的妊娠并发症,其发病机制尚未完全阐明。近年研究表明,糖酵解关键酶乳酸脱氢酶(lactate dehydrogenase,LDH)在PE发生发展中有重要作用。本文系统综述了PE患者血清及胎盘中LDH及其同工酶水平的异常改变对PE发病的影响;并深入分析LDH各亚基通过调控缺氧、炎症、自噬异常及细胞损伤等多重途径参与胎盘功能障碍的分子机制;最后,还探讨了LDH代谢产物乳酸在PE发病中的影响。LDH不仅是PE的潜在生物标志物,其介导的非代谢功能调控以及代谢重编程可能为PE防治提供新靶点。
Preeclampsia(PE) is a severe pregnancy complication that poses significant risks to maternal and fetal health,and its pathogenesis remains unclear. Recent studies have shown that lactate dehydrogenase(LDH),a key enzyme in glycolysis,plays a pivotal role in the development and progression of PE. This article reviews the abnormal changes in the levels of LDH and its isozymes in serum and placental tissue and their impact on the pathogenesis of PE and analyzes the molecular mechanisms by which LDH subunits contribute to placental dysfunction through multiple pathways including hypoxia,inflammation,autophagy dysregulation,and cellular damage. In addition,this article discusses the role of lactate,a metabolic product of LDH activity,in the pathogenesis of PE. LDH can be used as a potential biomarker for PE,and the regulation of non-metabolic functions and metabolic reprogramming mediated by LDH provide new targets for the prevention and treatment of PE.
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