1.西南大学药学院/中医药学院,重庆 400715
2.重庆医科大学附属第一医院急诊科,重庆 400016
Received:15 March 2025,
Revised:2025-04-17,
Accepted:29 April 2025,
Published:28 July 2025
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孙梦,钟杨,杨涵珺,等.地黄梓醇抗糖脂代谢紊乱相关疾病及其机制的研究进展[J].重庆医科大学学报,2025,50(7):849-859.
Sun Meng,Zhong Yang,Yang Hanjun,et al.Research progress on the mechanisms of action of catalpol from Rehmannia glutinosa against glycolipid metabolic disorders and related diseases[J].Journal of Chongqing Medical University,2025,50(7):849-859.
孙梦,钟杨,杨涵珺,等.地黄梓醇抗糖脂代谢紊乱相关疾病及其机制的研究进展[J].重庆医科大学学报,2025,50(7):849-859. DOI: 10.13406/j.cnki.cyxb.003857.
Sun Meng,Zhong Yang,Yang Hanjun,et al.Research progress on the mechanisms of action of catalpol from Rehmannia glutinosa against glycolipid metabolic disorders and related diseases[J].Journal of Chongqing Medical University,2025,50(7):849-859. DOI: 10.13406/j.cnki.cyxb.003857.
梓醇作为地黄的主要活性成分,具有良好的抗氧化、抗炎和调节糖脂代谢作用。本文整理并归纳了近年来关于梓醇对糖脂代谢紊乱相关疾病的影响及作用机制。发现梓醇能够纠正糖脂代谢紊乱,防治糖尿病并发症包括大血管和微血管病变的发生发展:梓醇能够通过调节5’-腺苷-磷酸活化蛋白激酶(adenosine 5’-monophosphate-activated protein kinase,AMPK)信号通路调控脂肪生成与氧化,影响叉头转录因子1(forehead transcription factor 1,FOXO1)和糖原合成酶激酶3(glycogen synthase kinase 3,GSK-3)的磷酸化进而调节糖原合成与分解,从而直接影响糖脂代谢。梓醇通过介导磷脂酰肌醇3-激酶(phosphatidylinositol 3-kinase,PI3K)/蛋白激酶B(protein kinase B,PKB或AKT)、氧化低密度脂蛋白(oxidized low-density lipoprotein,oxLDL)/凝集素样氧化低密度脂蛋白受体-1(lectin like oxidized low density lipoprotein receptor 1,LOX-1)等信号通路保护心脑血管系统、肾功能和视网膜结构与功能。梓醇还通过抑制核因子κB(nuclear factor kappa-light-chain-enhancer of activated B cells,NF-κB)信号通路以及内质网应激等方式减轻炎症反应,进一步缓解了由炎症引起的胰岛素抵抗和糖脂代谢紊乱。
Catalpol,the primary active component of
Rehmannia glutinosa
,exhibits potent antioxidant and anti-inflammatory effects and regulatory effects on glucose and lipid metabolism. This article systematically reviews recent studies on the impact of catalpol in addressing glycolipid metabolic disorders and related diseases and the underlying mechainsms. Catalpol can correct glucose and lipid metabolism imbalances to prevent the development and progression of diabetes complications including macrovascular and microvascular diseases,through modulating the adenosine 5’-monophosphate-activated protein kinase signaling pathway to regulate lipogenesis and fat oxidation and altering the phosphorylation of forkhead transcription factor 1 and glycogen synthase kinase 3 to influence glycogen synthesis and breakdown. Catalpol plays a protective role in the cardio-cerebrovascular system,renal function,and retinal structure and function through mediating signaling pathways such as phosphatidylinositol 3-kinase/protein kinase B and oxidized low-density lipoprotein /lectin-like oxidized low-density lipoprotein receptor-1. By suppressing the nuclear factor kappa-light-chain-enhancer of activated B cells pathway and endoplasmic reticulum stress,catalpol can alleviate inflammatory responses,thereby mitigating inflammation-induced insulin resistance and glycolipid metabolic disorders.
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