武汉大学人民医院肿瘤中心,武汉 430060
Received:28 February 2025,
Revised:2025-04-15,
Accepted:22 April 2025,
Published:28 June 2025
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张志敏,章必成.非小细胞肺癌免疫治疗热点问题解析[J].重庆医科大学学报,2025,50(6):726-733.
Zhang Zhimin,Zhang Bicheng.An analysis of hot issues in immunotherapy for non-small cell lung cancer[J].Journal of Chongqing Medical University,2025,50(6):726-733.
张志敏,章必成.非小细胞肺癌免疫治疗热点问题解析[J].重庆医科大学学报,2025,50(6):726-733. DOI: 10.13406/j.cnki.cyxb.003854.
Zhang Zhimin,Zhang Bicheng.An analysis of hot issues in immunotherapy for non-small cell lung cancer[J].Journal of Chongqing Medical University,2025,50(6):726-733. DOI: 10.13406/j.cnki.cyxb.003854.
以免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)为代表的免疫治疗已在非小细胞肺癌(non-small cell lung cancer,NSCLC)患者中广泛应用并取得了明显的治疗效果,获得国内外多个指南或专家共识的推荐。然目前的NSCLC免疫治疗中仍存在一些争议性的临床问题值得探讨,例如:围术期免疫治疗选择、免疫耐药机制及耐药后的治疗策略、免疫治疗疗效评估、免疫不良反应的管理、驱动基因阳性患者免疫治疗策略、特殊人群免疫治疗选择以及其他关注的免疫治疗临床问题等。本文列举了NSCLC免疫治疗中的7个热点问题并逐一进行解析,以期给肿瘤临床医师带来帮助。
Immunotherapy,represented by immune checkpoint inhibitors,has been widely used in patients with non-small cell lung cancer(NSCLC). With remarkable therapeutic efficacy,immunotherapy has been recommended by multiple domestic and international guidelines and expert consensuses. However,there are still some controversial clinical issues worth discussing in the current immunotherapy of NSCLC,such as perioperative immunotherapy selection,immune resistance mechanisms and treatment strategies after drug resistance,the evaluation of immunotherapy efficacy,the management of adverse immune reactions,immunotherapy strategies for driver gene-positive patients,immunotherapy selection in special populations,and other immunotherapy-related clinical issues of concern. This article presents and discusses seven hot issues in NSCLC immunotherapy,aiming to provide a reference for tumor clinicians.
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