武汉大学人民医院肿瘤中心,武汉 430000
Received:29 November 2024,
Revised:2025-03-10,
Accepted:19 March 2025,
Published:28 June 2025
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张铭博,宋羽霄,章必成.肿瘤相关巨噬细胞和T细胞亚群相互作用的研究进展[J].重庆医科大学学报,2025,50(6):714-720.
Zhang Mingbo,Song Yuxiao,Zhang Bicheng.Research advances in the interaction between tumor-associated macrophages and T cell subsets[J].Journal of Chongqing Medical University,2025,50(6):714-720.
张铭博,宋羽霄,章必成.肿瘤相关巨噬细胞和T细胞亚群相互作用的研究进展[J].重庆医科大学学报,2025,50(6):714-720. DOI: 10.13406/j.cnki.cyxb.003843.
Zhang Mingbo,Song Yuxiao,Zhang Bicheng.Research advances in the interaction between tumor-associated macrophages and T cell subsets[J].Journal of Chongqing Medical University,2025,50(6):714-720. DOI: 10.13406/j.cnki.cyxb.003843.
肿瘤相关巨噬细胞在肿瘤微环境中占据主要地位,在传统上被分为M1和M2型,但近年来研究发现其内部异质性大,不能简单归类。T细胞在肿瘤免疫中扮演关键角色,其种群数量和功能状态直接影响治疗效果,肿瘤相关巨噬细胞与T细胞各亚群CD4
+
T细胞、调节性T细胞和CD8
+
T细胞之间的相互作用对肿瘤免疫治疗具有指导意义。肿瘤相关巨噬细胞与T细胞的相互作用涉及多种分子和信号通路,包括程序性死亡受体1及其配体、细胞因子及其受体等。此外,外源性因素如放化疗和感染也会对二者的相互作用产生影响。研究肿瘤免疫微环境内巨噬细胞类群和不同亚群T细胞间的相互作用,有助于理解病灶内部的免疫状态和机制,为肿瘤免疫治疗提供新靶点和新策略。
Tumor-associated macrophages(TAMs) play a pivotal role in the tumor microenvironment and have traditionally been classified into M1 and M2 phenotypes;however,recent studies have revealed considerable internal heterogeneity among these macrophages,which requires a more detailed classification. T cells play a key role in tumor immunity,and their population dynamics and functional states have a direct impact on therapeutic outcomes. The interactions between TAMs and various T cell subsets,including CD4
+
T cells,regulatory T cells,and CD8
+
T cells,have a guiding significance for tumor immunotherapy. Such interactions between TAMs and T cells involve a variety of molecules and signaling pathways,such as programmed death receptor 1 and its ligand,as well as various cytokines and their receptors. Furthermore,exogenous factors,including chemoradiotherapy and infections,can also influence these interactions. Research on the interactions
between different macrophage populations and T cell subsets within the tumor immune microenvironment can help to understand immune status and mechanism in lesions,thereby providing new targets and strategies for tumor immunotherapy.
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