Research advances in the mechanism of exosomes derived from cancer-associated fibroblasts in regulating tumor drug resistance

Wu Jiafan; Liu Yuan; Huang Wenwen; Li Xiao; Wang Xinyu; Li Ruhong

doi:10.13406/j.cnki.cyxb.003837

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Research advances in the mechanism of exosomes derived from cancer-associated fibroblasts in regulating tumor drug resistance

Precision medicine in cancer and translational studies | 更新时间：2026-02-13

- Research advances in the mechanism of exosomes derived from cancer-associated fibroblasts in regulating tumor drug resistance
- Journal of Chongqing Medical University Vol. 51, Issue 1, Pages: 78-83(2026)
- 作者机构：
  
  昆明医科大学附属延安医院普外科/云南省肿瘤免疫防治研究重点实验室，昆明 650000
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.003837
  CLC： R34
- Received：03 December 2024，
  
  Revised：2025-02-25，
  
  Published：28 January 2026
- 稿件说明：
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武家帆,刘源,黄文文等.肿瘤相关成纤维细胞源性外泌体调控肿瘤耐药机制的研究进展[J].重庆医科大学学报,2026,51(01):78-83.

Wu Jiafan,Liu Yuan,Huang Wenwen,et al.Research advances in the mechanism of exosomes derived from cancer-associated fibroblasts in regulating tumor drug resistance[J].Journal of Chongqing Medical University,2026,51(01):78-83.
武家帆,刘源,黄文文等.肿瘤相关成纤维细胞源性外泌体调控肿瘤耐药机制的研究进展[J].重庆医科大学学报,2026,51(01):78-83. DOI： 10.13406/j.cnki.cyxb.003837.

Wu Jiafan,Liu Yuan,Huang Wenwen,et al.Research advances in the mechanism of exosomes derived from cancer-associated fibroblasts in regulating tumor drug resistance[J].Journal of Chongqing Medical University,2026,51(01):78-83. DOI： 10.13406/j.cnki.cyxb.003837.

摘要

肿瘤微环境（tumor microenvironment，TME）作为肿瘤细胞赖以生存的内环境，在肿瘤治疗和耐药中起着举足轻重的作用。其中肿瘤相关成纤维细胞（cancer-associated fibroblast，CAF）可以重塑细胞外基质、分泌可溶性因子和释放细胞外囊泡，从而调控肿瘤生物学进程，并影响肿瘤耐药。CAF源性外泌体（CAF-derived exosome，CDE）即CAF释放的胞外囊泡，成为拓展CAF研究领域的关键一环，其可影响肿瘤发生发展进程，尤其对肿瘤放化疗耐药机制形成有重要作用。本文综述了CAF及CDE在肿瘤耐药中的作用，阐述了不同肿瘤耐药形成过程中CDE的具体调控机制，并对CDE在抑制肿瘤耐药形成中的应用进行了讨论与展望。

Abstract

Tumor microenvironment，as the indispensable internal environment for tumor cells，plays a pivotal role in tumor therapy and drug resistance. Cancer-associated fibroblasts（CAF） can remodel the extracellular matrix，secrete soluble factors，and release extracellular vesicles，thereby regulating the biological process of tumors and affecting the drug resistance of tumors. As the extracellular vesicles released by CAF，CAF-derived exosomes（CDE） has become a key link in expanding the research field of CAF，and it can affect the process of tumor development and progression and play an important role in the formation of tumor drug resistance to chemotherapy and radiotherapy. This article reviews the role of CAF and CDE in tumor drug resistance，elaborates on the specific regulatory mechanisms of CDE in the formation of drug resistance in different types of tumor，and discusses the application and perspectives of CDE in inhibiting the formation of drug resistance in tumors.

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