Shen Anle,Han Yali,Yu Liting,et al.Analysis of the safety of dinutuximab β for the treatment of neuroblastoma[J].Journal of Chongqing Medical University,2025,50(8):1042-1046.
Shen Anle,Han Yali,Yu Liting,et al.Analysis of the safety of dinutuximab β for the treatment of neuroblastoma[J].Journal of Chongqing Medical University,2025,50(8):1042-1046. DOI: 10.13406/j.cnki.cyxb.003814.
Analysis of the safety of dinutuximab β for the treatment of neuroblastoma
To analyze the clinical characteristics of adverse reactions caused by dinutuximab β for the treatment of neuroblastoma(NB) in China and to provide safety evidence for the rational use of dinutuximab β in clinical practice.
Methods
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Clinical data were retrospectively collected from 16 pediatric patients with NB who had been treated with dinutuximab β at Shanghai Children’s Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine from January 2022 to November 2023,and the adverse reactions caused by dinutuximab β were summarized and analyzed.
Results
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The male-to-female ratio was 5:3 among the 16 children with NB. The retroperitoneum was the main initial site of involvement,accounting for 75%. Thirteen(81.25%) patients had high-risk NB. The adverse reactions caused by dinutuximab β mainly included decreased hemoglobin,fever,vomiting,and diarrhea. The incidence of adverse reactions was highest in the first course of treatment,and the median time of adverse reactions was 2-5 days.
Conclusion
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Targeted monitoring should be carried out at an early stage during dinutuximab β administration. Adverse reactions should be detected and managed early to ensure the safety of medication for children.
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references
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