Wang Zhixu,Song Yuxiao,Zhang Bicheng.Metabolic reprogramming of polyamines in macrophages and T cells within the tumor microenvironment[J].Journal of Chongqing Medical University,2025,50(6):721-725.
Wang Zhixu,Song Yuxiao,Zhang Bicheng.Metabolic reprogramming of polyamines in macrophages and T cells within the tumor microenvironment[J].Journal of Chongqing Medical University,2025,50(6):721-725. DOI: 10.13406/j.cnki.cyxb.003802.
Metabolic reprogramming of polyamines in macrophages and T cells within the tumor microenvironment
In the tumor microenvironment(TME),the metabolic reprogramming of macrophages and T cells plays a critical role in the formation of an immunosuppressive state and tumor immune escape. Polyamines are key signaling molecules and precursors for biosynthesis,and the metabolic state of polyamines profoundly regulate the functions of tumor cells and immune cells. Cytokines and other substances within the TME induce the expression of enzymes related to polyamine metabolism,drive the metabolic reprogramming of polyamines,and thus influence macrophage polarization and T cell differentiation; meanwhile,the metabolic reprogramming of polyamines leads to the competitive depletion of polyamine resources within the TME,promote tumor cells to optimize their metabolic strategies for survival advantages,and inhibit the function of immune cells. Therefore,inhibitors of polyamine metabolism may be used as antitumor drugs by regulating metabolic reprogramming.
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