1.甘肃中医药大学中医临床学院,兰州 730101
2.甘肃中医药大学敦煌医学与转化教育部重点实验室,兰州 730101
Received:17 November 2024,
Revised:2025-02-20,
Accepted:24 February 2025,
Published:28 December 2025
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苏苗,李金田,洪涛.气道上皮祖细胞在慢性阻塞性肺疾病中的研究进展[J].重庆医科大学学报,2025,50(12):1689-1694.
Su Miao,Li Jintian,Hong Tao.Research advances in airway epithelial progenitor cells in chronic obstructive pulmonary disease[J].Journal of Chongqing Medical University,2025,50(12):1689-1694.
苏苗,李金田,洪涛.气道上皮祖细胞在慢性阻塞性肺疾病中的研究进展[J].重庆医科大学学报,2025,50(12):1689-1694. DOI: 10.13406/j.cnki.cyxb.003797.
Su Miao,Li Jintian,Hong Tao.Research advances in airway epithelial progenitor cells in chronic obstructive pulmonary disease[J].Journal of Chongqing Medical University,2025,50(12):1689-1694. DOI: 10.13406/j.cnki.cyxb.003797.
慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)是一种常见的可预防和治疗的慢性气道疾病,患病率和死亡率均较高。气道上皮损伤与COPD的发病机制及其呼吸系统并发症密切相关。气道上皮祖细胞主要来源于气道分泌细胞,可以修复受损的气道上皮。许多研究表明,COPD患者的气道上皮祖细胞减少且功能失调,这可能是COPD和呼吸系统并发症的重要原因。本文就COPD中气道上皮祖细胞的功能及减少和功能失调的机制研究进展进行综述,以期为COPD的治疗和预后靶点提供新的思路。
Chronic obstructive pulmonary disease(COPD) is a common chronic airway disease that can be prevented and treated, with relatively high prevalence and mortality rates. Airway epithelial injury is closely associated with the pathogenesis of COPD and its respiratory complications. Airway epithelial progenitor cells mainly come from airway secretory cells and can repair the damaged airway epithelium. Many studies have shown that the reduction in the number of airway epithelial progenitor cells and dysfunction of these cells may be important causes of COPD and respiratory complications. This article reviews the research advances in the function of airway epithelial progenitor cells in COPD and the mechanisms of the reduction and dysfunction of these cells, in order to provide new ideas for the treatment of COPD and related prognosis targets .
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