Neurovascular coupling in patients with depression：a study based on multimodal magnetic resonance imaging

Zhao Yue; Guo Yuanyuan; Li Chenglong; Zhang Juanjuan; Tian Yanghua

doi:10.13406/j.cnki.cyxb.003781

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Neurovascular coupling in patients with depression：a study based on multimodal magnetic resonance imaging

Frontiers in brain science and neuropsychiatric disorders | 更新时间：2025-10-22

- Neurovascular coupling in patients with depression：a study based on multimodal magnetic resonance imaging
- Journal of Chongqing Medical University Vol. 50, Issue 6, Pages: 778-784(2025)
- 作者机构：
  
  1.安徽医科大学第一附属医院神经内科，合肥 230022
  2.安徽医科大学第三附属医院神经内科，合肥 230061
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.003781
  CLC： R749.4
- Received：26 September 2024，
  
  Revised：2024-11-30，
  
  Accepted：13 January 2025，
  
  Published：28 June 2025
- 稿件说明：
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赵越,郭媛媛,李成龙,等.基于多模态核磁共振探讨抑郁症患者的神经血管耦合研究[J].重庆医科大学学报,2025,50(6):778-784.

Zhao Yue,Guo Yuanyuan,Li Chenglong,et al.Neurovascular coupling in patients with depression：a study based on multimodal magnetic resonance imaging[J].Journal of Chongqing Medical University,2025,50(6):778-784.
赵越,郭媛媛,李成龙,等.基于多模态核磁共振探讨抑郁症患者的神经血管耦合研究[J].重庆医科大学学报,2025,50(6):778-784. DOI： 10.13406/j.cnki.cyxb.003781.

Zhao Yue,Guo Yuanyuan,Li Chenglong,et al.Neurovascular coupling in patients with depression：a study based on multimodal magnetic resonance imaging[J].Journal of Chongqing Medical University,2025,50(6):778-784. DOI： 10.13406/j.cnki.cyxb.003781.

摘要

目的

使用静息态功能磁共振和动脉自旋标记灌注磁共振，分析抑郁症（depression，DEP）患者的神经血管耦合改变，并探究其与抑郁症状之间的关系。

方法

对25例DEP患者和35例健康对照（healthy controls，HC）进行神经心理学评估和多模态磁共振扫描。通过动脉自旋标记灌注磁共振计算脑血流量（cerebral blood flow，CBF），通过功能磁共振计算局部一致性（regional homogeneity，ReHo）。最后计算CBF和ReHo之间的皮尔逊相关系数以获得神经血管耦合。

结果

在全脑水平，与HC相比，DEP患者CBF-ReHo耦合降低。在脑区水平，DEP患者CBF-ReHo耦合降低的有26个脑区，主要位于视觉网络、默认网络和听觉网络。进一步相关性分析发现，左侧枕下回、左侧角回、左侧丘脑的耦合值与汉密尔顿抑郁量表（hamilton depression scale，HAMD）评分呈负相关。

结论

DEP患者存在明显降低的神经血管耦合，并且与抑郁的严重程度相关。

Abstract

Objective

To investigate altered neurovascular coupling in patients with depression（DEP） using resting-state functional magnetic resonance imaging（MRI） and arterial spin labeling perfusion MRI，as well as its association with depressive symptoms.

Methods

Neuropsychological assessment and multimodal MRI scans were performed for 25 DEP patients and 35 healthy controls （HCs）. Arterial spin labeling perfusion MRI was used to calculate cerebral blood flow（CBF），and functional MRI was used to calculate regional homogeneity （ReHo）. The Pearson correlation coefficient between CBF and ReHo was calculated to obtain neurovascular coupling.

Results

At the whole-brain level，CBF-ReHo coupling was reduced in DEP patients compared with HCs. At the brain region level，CBF-ReHo coupling was reduced in 26 brain regions in DEP patients，which were mainly located in the visual network，the default network，and the auditory network. The correlation analysis showed that the coupling values of the left suboccipital gyrus，the left angular gyrus，and the left thalamus were negatively correlated with Hamilton Depression Scale score.

Conclusion

There is a significant reduction in neurovascular coupling in DEP patients，which is correlated with the severity of DEP.

关键词

Keywords

references

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