Febrile infection-related epilepsy syndrome

Wu Ye; Sang Tian; Guan Qian

doi:10.13406/j.cnki.cyxb.003752

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Febrile infection-related epilepsy syndrome

Febrile Infection-Related Epilepsy Syndrome Column | 更新时间：2025-10-22

- Febrile infection-related epilepsy syndrome
- Journal of Chongqing Medical University Vol. 50, Issue 3, Pages: 275-279(2025)
- 作者机构：
  
  北京大学第一医院儿童医学中心，北京 102627
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.003752
  CLC： R729
- Received：15 December 2024，
  
  Revised：2025-01-04，
  
  Accepted：13 January 2025，
  
  Published：28 March 2025
- 稿件说明：
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吴晔,桑田,管巧.热性感染相关性癫痫综合征[J].重庆医科大学学报,2025,50(0):275-279.

Wu Ye,Sang Tian,Guan Qian.Febrile infection-related epilepsy syndrome[J].Journal of Chongqing Medical University,2025,50(0):275-279.
吴晔,桑田,管巧.热性感染相关性癫痫综合征[J].重庆医科大学学报,2025,50(0):275-279. DOI： 10.13406/j.cnki.cyxb.003752.

Wu Ye,Sang Tian,Guan Qian.Febrile infection-related epilepsy syndrome[J].Journal of Chongqing Medical University,2025,50(0):275-279. DOI： 10.13406/j.cnki.cyxb.003752.

摘要

热性感染相关性癫痫综合征（febrile infection-related epilepsy syndrome，FIRES）是一种发生在既往健康的儿童和青少年的炎症相关急性脑病，以热性感染后出现的超级难治性癫痫持续状态为临床特征，多数预后不良。近年来随着对该病认识的加深，治疗理念也有所转变，更提倡在规范抗癫痫发作治疗的基础上，早期及时免疫治疗和综合支持。本文从FIRES的定义、临床特征、辅助检查、发病机制、诊断及评估、治疗、预后和未来研究方向进行了全面阐述，以期提高认识，改善预后。

Abstract

Febrile infection-related epilepsy syndrome is an inflammation-related acute encephalopathy that occurs in previously healthy children and adolescents. It is clinically characterized by super-refractory status epilepticus that occurs after a febrile infection and is often associated with poor prognosis. In recent years，with a deeper understanding of this disease，the treatment approaches have shifted to early and timely immunotherapy and comprehensive support on the basis of standardized anti-epileptic seizure treatment. This review comprehensively elaborates the definition，clinical characteristics，auxiliary examinations，pathogenesis，diagnosis and evaluation，treatment，prognosis，and future research directions of febrile infection-related epilepsy syndrome，aiming to enhance understanding and improve prognosis.

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references

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