Impact of the proportion of follicles with a diameter of ≥17 mm on trigger day on the pregnancy outcome of assisted reproductive technology during controlled ovarian hyperstimulation

Wang Mengdi; Li Yingxing; Lü Xingyu; Enoch Appiah Adu-Gyamfi; Tang Xiaojun; Zhong Zhaohui; Ding Yubin

doi:10.13406/j.cnki.cyxb.003732

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Impact of the proportion of follicles with a diameter of ≥17 mm on trigger day on the pregnancy outcome of assisted reproductive technology during controlled ovarian hyperstimulation

Endometrial carcinogenesis and assisted reproductive technology | 更新时间：2025-10-23

- Impact of the proportion of follicles with a diameter of ≥17 mm on trigger day on the pregnancy outcome of assisted reproductive technology during controlled ovarian hyperstimulation
- Journal of Chongqing Medical University Vol. 50, Issue 2, Pages: 230-236(2025)
- 作者机构：
  
  1.重庆医科大学公共卫生学院，重庆 400016
  2.四川锦欣西囡妇女儿童医院生殖医学科，成都 610011
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.003732
  CLC： R173
- Received：13 February 2024，
  
  Revised：2024-03-11，
  
  Accepted：10 May 2024，
  
  Published：28 February 2025
- 稿件说明：
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王梦迪,李莹星,吕兴钰,等.控制性超促排卵过程中扳机日直径≥17 mm卵泡占比对辅助生殖助孕结局的影响[J].重庆医科大学学报,2025,50(2):230-236.

Wang Mengdi,Li Yingxing,Lü Xingyu,et al.Impact of the proportion of follicles with a diameter of ≥17 mm on trigger day on the pregnancy outcome of assisted reproductive technology during controlled ovarian hyperstimulation[J].Journal of Chongqing Medical University,2025,50(2):230-236.
王梦迪,李莹星,吕兴钰,等.控制性超促排卵过程中扳机日直径≥17 mm卵泡占比对辅助生殖助孕结局的影响[J].重庆医科大学学报,2025,50(2):230-236. DOI： 10.13406/j.cnki.cyxb.003732.

Wang Mengdi,Li Yingxing,Lü Xingyu,et al.Impact of the proportion of follicles with a diameter of ≥17 mm on trigger day on the pregnancy outcome of assisted reproductive technology during controlled ovarian hyperstimulation[J].Journal of Chongqing Medical University,2025,50(2):230-236. DOI： 10.13406/j.cnki.cyxb.003732.

摘要

目的

分析扳机日直径≥17 mm卵泡占比（直径≥17 mm卵泡数/直径≥14 mm卵泡数）对辅助生殖患者助孕结局的影响。

方法

回顾性分析2018年7月至2023年9月于成都锦欣西囡妇科医院行体外受精/胞浆内单精子注射（

in vitro

fertilization，IVF/intracytoplasmic sperm injection，ICSI）助孕的3 848个周期。每位患者接受卵泡期长效长方案或拮抗剂方案治疗。通过直径≥17 mm卵泡占比分为A、B、C 3组（卵泡期长效长方案：A组：≤60%，B组：61%~73%，C组：

73%；拮抗剂方案：A组：≤62%，B组：63%~75%，C组：

75%），使用多因素logistic回归评估直径≥17 mm卵泡占比是否影响患者的活产率，临床妊娠率和流产率等助孕结局。

结果

①卵泡期长效长方案：以A组为参考，多因素logistic回归分析结果显示，C组的流产风险是A组的1.700倍（95%CI=1.123~2.576；

=0.012）。此外，未发现直径≥17 mm卵泡占比对患者的活产率、卵巢过度刺激综合征（ovarian hyperstimulation syndrome，OHSS）发生率、临床妊娠率的影响。②拮抗剂方案：未发现直径≥17 mm卵泡占比与患者助孕结局之间存在关联。

结论

对于接受卵泡期长效长方案的患者而言，扳机日直径≥17 mm卵泡占比越高，患者的流产风险越大。对于接受拮抗剂方案治疗的患者而言，未发现直径≥17 mm卵泡占比与不良妊娠结局之间的关联。

Abstract

Objective

To investigate the impact of the proportion of follicles with a diameter of ≥17 mm on trigger day（follicles≥17 mm/follicles≥14 mm） on the pregnancy outcome of patients receiving assisted reproductive technology.

Methods

A retrospective analysis was performed for the data of 3848 cycles of

in vitro

fertilization/intracytoplasmic sperm injection for promoting pregnancy in Chengdu Jinxin Xinan Women’s Hospital from July 2018 to September 2023，and the patients received the long-acting long regimen or the antagonist regimen in the follicular phase. According to the proportion of follicles with a diameter of ≥17 mm，the patients were divided into groups A，B，and C（the long-acting long regimen： ≤60% for group A，61%-73% for group B，and

73% for group C；the antagonist regimen：≤62% for group A，63%-75% for group B，and

75%

for group C）. A multivariate logistic regression analysis was used to assess the impact of the proportion of follicles with a diameter of ≥17 mm on the pregnancy outcomes of patients，including live birth rate，clinical pregnancy rate，and miscarriage rate.

Results

As for the long-acting long regimen in the follicular phase，the multivariate logistic regression analysis showed that the risk of miscarriage in group C was 1.700 times that in group A（95%CI=1.123~2.576，

=0.012），and in addition，the proportion of follicles with a diameter of ≥17 mm had no impact on live birth rate，the incidence rate of ovarian hyperstimulation syndrome，or clinical pregnancy rate. As for the antagonist regimen，no association was found between the proportion of follicles with a diameter of ≥17 mm and the pregnancy outcomes of the patients.

Conclusion

For the patients receiving the long-acting long regimen in the follicular phase，the risk of miscarriage increases with the increase in the proportion of follicles with a diameter of ≥17 mm on trigger day，while for the patients receiving the antagonist regimen，no association is found between the proportion of follicles with a diameter of ≥17 mm on trigger day and adverse pregnancy outcomes.

关键词

Keywords

references

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