上海交通大学医学院附属第六人民医院减重代谢外科,上海 200233
Received:21 February 2024,
Revised:2024-05-17,
Accepted:13 September 2024,
Published:28 August 2025
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赵亚聪,王晨,狄建忠.GLP-1受体激动剂类药物在肥胖治疗中的研究现状[J].重庆医科大学学报,2025,50(8):1011-1015.
Zhao Yacong,Wang Chen,Di Jianzhong.Research status of GLP-1 receptor agonists in the treatment of obesity[J].Journal of Chongqing Medical University,2025,50(8):1011-1015.
赵亚聪,王晨,狄建忠.GLP-1受体激动剂类药物在肥胖治疗中的研究现状[J].重庆医科大学学报,2025,50(8):1011-1015. DOI: 10.13406/j.cnki.cyxb.003722.
Zhao Yacong,Wang Chen,Di Jianzhong.Research status of GLP-1 receptor agonists in the treatment of obesity[J].Journal of Chongqing Medical University,2025,50(8):1011-1015. DOI: 10.13406/j.cnki.cyxb.003722.
肥胖作为一种慢性复杂疾病,会引起很多其他疾病。肥胖的产生受多种因素的影响。现有肥胖的治疗方式主要是行为干预、药物治疗、内镜治疗及胃袖状切除手术等。其中药物治疗方面一直有新的突破和进展。本文主要介绍了胰高血糖素样肽-1(glucagon-like peptide-1,GLP-1)受体激动剂中几种代表性药物例如利拉鲁肽(liraglutide)、司美格鲁肽(semaglutide)、替尔泊肽(tirzepatide)等最新临床情况以及使用后的不良反应。本文章主要是对这些抗肥胖药物的安全性和有效性进行分析,为日后临床用药提供了指导意见。
As a chronic and complex disease,obesity can cause many other diseases. Obesity is influenced by many factors. At present,the main treatment methods for obesity are behavioral intervention,medication,endoscopic therapy,and sleeve gastrectomy. New breakthroughs and progress have achieved in medication. This article mainly introduces the latest clinical situation and adverse reactions of several representative drugs in glucagon-like peptide-1 receptor agonists,such as liraglutide,semaglutide,and tirzepatide. This article mainly aims to analyze the safety and efficacy of these anti-obesity drugs and provide guidance for future clinical medication.
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