Effect of electroconvulsive therapy on brain-derived neurotrophic factor and oxidative stress factors in adolescents with major depressive disorder

Wang Yuna; Du Ning; Geng Dandan; Ran Pan; Xu Heyan; Guo Jiamei; Kuang Li

doi:10.13406/j.cnki.cyxb.003720

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Effect of electroconvulsive therapy on brain-derived neurotrophic factor and oxidative stress factors in adolescents with major depressive disorder

Clinical research | 更新时间：2025-10-23

- Effect of electroconvulsive therapy on brain-derived neurotrophic factor and oxidative stress factors in adolescents with major depressive disorder
- Journal of Chongqing Medical University Vol. 50, Issue 1, Pages: 123-129(2025)
- 作者机构：
  
  重庆医科大学附属第一医院精神医学中心，重庆 400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.003720
  CLC： 749.4
- Received：14 September 2024，
  
  Revised：2024-12-06，
  
  Accepted：11 December 2024，
  
  Published：28 January 2025
- 稿件说明：
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王余娜,杜宁,耿丹丹,等.电休克对青少年重度抑郁症BDNF和氧化应激因子的影响[J].重庆医科大学学报,2025,50(1):123-129.

Wang Yuna,Du Ning,Geng Dandan,et al.Effect of electroconvulsive therapy on brain-derived neurotrophic factor and oxidative stress factors in adolescents with major depressive disorder[J].Journal of Chongqing Medical University,2025,50(1):123-129.
王余娜,杜宁,耿丹丹,等.电休克对青少年重度抑郁症BDNF和氧化应激因子的影响[J].重庆医科大学学报,2025,50(1):123-129. DOI： 10.13406/j.cnki.cyxb.003720.

Wang Yuna,Du Ning,Geng Dandan,et al.Effect of electroconvulsive therapy on brain-derived neurotrophic factor and oxidative stress factors in adolescents with major depressive disorder[J].Journal of Chongqing Medical University,2025,50(1):123-129. DOI： 10.13406/j.cnki.cyxb.003720.

摘要

目的

为探究电休克（electroconvulsive therapy，ECT）治疗对重度抑郁症（major depressive disorder，MDD）青少年患者的疗效，进行MDD青少年患者电休克治疗期间氧化应激水平、血清脑源性神经营养因子（brain-derived neurotrophic factor，BDNF）和抑郁程度的相关性分析。

方法

选择2023年5月至2023年12月在重庆医科大学附属第一医院38例重度抑郁症青少年患者为回顾性分析试验组（MDD组），采用问卷招募20例健康儿童作对照组。电休克治疗前及治疗结束后，采集MDD组17项汉密尔顿抑郁量表（17-items Hamilton depression scale，HAMD-17）、心理弹性量表（connor-davidson resilience scale，CD-RISC）等量表评分，并检测超氧化物歧化酶（superoxide dismutase，SOD）、丙二醛（malondialdehyde，MDA）、BDNF水平。对照组仅采集血样和人口学数据。

结果

MDD组治疗前的SOD和BDNF低于对照组（

0.001），差异具有统计学意义。MDA高于对照组（

0.001）。经过电休克治疗后，MDD组SOD较治疗前增高（

0.001）、BDNF较治疗前增高（

0.001），MDA较治疗前降低（

0.001），SOD、MDA、BDNF治疗后与治疗前比较差异均有统计学意义。HAMD-17治疗后降低（

0.001）、PDQ-D治疗后降低（

=0.004）、CFQ量表评分治疗后降低（

=0.001），评分差异有统计学意义；CD-RISC、AAQ-2量表评分治疗前后无统计学意义。相关性分析显示电休克治疗前后的SOD、MDA、BDNF分别和治疗前后HAMD-17评分存在弱相关性。多元逻辑回归分析显示电休克治疗前SOD水平能作为ECT治疗应答的独立影响因素，治疗前MDA、BDNF水平对HAMD-17治疗后评分差异无统计学意义。

结论

ECT治疗后，患者血清中SOD和BDNF升高、MDA降低。MDA降低，SOD和BDNF的增加与抑郁改善程度具有弱相关性，推测ECT治疗可改善MDD青少年患者抑郁症状，具体机制与SOD、MDA、BDNF改变有关，但3种指标能否成为预测电休克改善抑郁症状的独立影响因素还需进一步研究。

Abstract

Objective

To investigate the effect of electroconvulsive therapy （ECT） on adolescents with major depressive disorder （MDD），as well as the correlation of oxidative stress and brain-derived neurotrophic factor （BDNF） with the degree of depression in adolescents with MDD during ECT.

Methods

A total of 38 adolescents with MDD from May to December 2023 were enrolled as retrospective analysis group（MDD group），and 20 healthy children were recruited as control group through a questionnaire survey. Before and after ECT，the scores of 17-item Hamilton Depression Rating Scale（HAMD-17） and Connor-Davidson Resilience Scale（CD-RISC） were collected from the adolescents in the experimental group，and the serum levels of superoxide dismutase（SOD），malondialdehyde（MDA），and BDNF were measured. Only blood samples and demographic data were collected for the control group.

Results

Compared with the control group，the MDD group had significantly lower levels of SOD and BDNF（

0.001） and a significantly higher level of MDA（

0.001） before treatment. After ECT，the MDD group had significant increases in SOD and BDNF（

0.001） and a significant reduction in MDA（

0.001）. After treatment，there were significant reductions in the scores of HAMD-17（

0.001），PDQ-D（

=0.004），and CFQ（

=0.001），while there were no significant changes in the scores of CD-RISC and AAQ-2 after treatment. The correlation analysis showed that SOD，MDA，and BDNF were weakly correlated with HAMD-17 score before and after ECT. The multivariate logistic regression analysis showed that SOD level before ECT was an independent influencing factor for treatment response to ECT，while the levels of MDA and BDNF before treatment had no statistical significance on HAMD-17 score after treatment.

Conclusion

There are increases in the serum levels of SOD and BDNF and a reduction in the serum level of MDA after ECT. The reduction in MDA and the increases in SOD and BDNF have a weak correlation with the degree of improvement in depression，and it is speculated that ECT can improve depressive symptoms in adolescents with MDD，which is associated with the changes in SOD，MDA，and BDNF. However，further studies are needed to investigate whether these three indicators can be used as independent influencing factors to predict the improvement in depressive symptoms by ECT.

关键词

Keywords

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