Wang Zhen,Yang Yuli,Li Xiaomei,et al.Research advances in the influencing factors for exposure keratopathy and related treatment methods[J].Journal of Chongqing Medical University,2024,49(12):1541-1544.
Wang Zhen,Yang Yuli,Li Xiaomei,et al.Research advances in the influencing factors for exposure keratopathy and related treatment methods[J].Journal of Chongqing Medical University,2024,49(12):1541-1544. DOI: 10.13406/j.cnki.cyxb.003686.
Research advances in the influencing factors for exposure keratopathy and related treatment methods
Exposure keratopathy is a clinical syndrome characterized by incomplete closure of the eyelids and tear film defects and may result in a series of severe corneal injuries. Patients mainly have the early symptoms of eye discomfort and pain,which may lead to irreversible visual impairment without timely treatment and thus seriously affect the quality of life and physical and mental health of patients. This article summarizes the influencing factors and treatment methods for exposure keratopathy,in order to improve the vigilance of healthcare workers and the awareness of self-protection and treatment compliance among patients,reduce the incidence rate of the disease,and provide reference for developing safe and effective treatment regimens in clinical practice.
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Kousha O , Kousha Z , Paddle J . Exposure keratopathy:incidence,risk factors and impact of protocolised care on exposure keratopathy in critically ill adults [J ] . J Crit Care , 2018 , 44 : 413 - 418 .
Chen YL , He J , Wu QP , et al . Prevalence and risk factors of exposure keratopathy among critically ill patients:a systematic review and meta-analysis [J ] . Nurs Open , 2024 , 11 ( 1 ): e2061 .
Almulhim A . Therapeutic targets in the management of dry eye disease associated with sjögren’s syndrome:an updated review of current insights and future perspectives [J ] . J Clin Med , 2024 , 13 ( 6 ): 1777 .
Kaye AD , Renschler JS , Cramer KD , et al . Postoperative management of corneal abrasions and clinical implications:a comprehensive review [J ] . Curr Pain Headache Rep , 2019 , 23 ( 7 ): 48 .
Li AQ , Jin PY , Xie B , et al . Analysis on the status of exposure keratopathy in comatose patients of ICU and its influencing factors [J ] . J Nurses Train , 2022 , 37 ( 8 ): 705 - 709,717 .
Li JO , Lam DSC , Chen YX , et al . Novel Coronavirus disease 2019 (COVID-19):the importance of recognising possible early ocular manifestation and using protective eyewear [J ] . Br J Ophthalmol , 2020 , 104 ( 3 ): 297 - 298 .
Sanders RN , Elhusseiny AM , Chauhan MZ , et al . Association between systematic use of bio-occlusive dressing and general anaesthesia-associated corneal injury [J ] . Br J Anaesth , 2022 , 129 ( 6 ): e153 - e155 .
Warad C , Mohapatra S , Mehta A . Bedside assessment of ophthalmic manifestations in neurocritical care:a study in Southern India [J ] . Indian J Ophthalmol , 2024 , 72 ( 2 ): 201 - 205 .
Lahiji AP , Gohari M , Mirzaei S , et al . The effect of implementation of evidence-based eye care protocol for patients in the intensive care units on superficial eye disorders [J ] . BMC Ophthalmol , 2021 , 21 ( 1 ): 275 .
Mobarez F , Sayadi N , Jahani S , et al . The effect of eye care protocol on the prevention of ocular surface disorders in patients admitted to intensive care unit [J ] . J Med Life , 2022 , 15 ( 8 ): 1000 - 1004 .
Singh RB , Khera T , Ly V , et al . Ocular complications of perioperative anesthesia:a review [J ] . Graefes Arch Clin Exp Ophthalmol , 2021 , 259 ( 8 ): 2069 - 2083 .
Muralidhar A , Das S , Tiple S . Clinical profile of thyroid eye disease and factors predictive of disease severity [J ] . Indian J Ophthalmol , 2020 , 68 ( 8 ): 1629 - 1634 .
Pucker AD , Yim TW , Rueff E , et al . LipiFlow for the treatment of dry eye disease [J ] . Cochrane Database Syst Rev , 2024 , 2 ( 2 ): CD015448 .
Park CS , Kim SH , Lee CK . Immunotherapy of autoimmune diseases with nonantibiotic properties of tetracyclines [J ] . Immune Netw , 2020 , 20 ( 6 ): e47 .
Chu LY , Wang CM , Zhou HY . Inflammation mechanism and anti-inflammatory therapy of dry eye [J ] . Front Med , 2024 , 11 : 1307682 .
Li FY . Research advances in the treatment of exposed keratitis after general anesthesia surgery [J ] . J Hubei Polytech Inst , 2022 , 25 ( 3 ): 103 - 107 .
Roberts JK , Meekins JM , Roush JK , et al . Effects of topical instillation of 0.1% diclofenac sodium,0.5% ketorolac tromethamine,and 0.03% flurbiprofen sodium on corneal sensitivity in ophthalmologically normal cats [J ] . Am J Vet Res , 2021 , 82 ( 1 ): 81 - 87 .
Merino-Bohórquez V , Berisa-Prado S , Delgado-Valverde M , et al . Physicochemical and microbiological stability study of two new preservative-free methylprednisolone eye drops [J ] . Farm Hosp , 2024 , 48 ( 4 ): T145 - T152 .
Erdinest N , Pincovich S , London N , et al . Neurostimulation for dry eye disease [J ] . Curr Opin Allergy Clin Immunol , 2022 , 22 ( 5 ): 328 - 334 .
Shoji J , Inada N , Tomioka A , et al . Assessment of mucin-related gene alterations following treatment with rebamipide ophthalmic suspension in Sjögren’s syndrome-associated dry eyes [J ] . PLoS One , 2020 , 15 ( 11 ): e0242617 .
Dong Y , Yin HN , Pi YL , et al . The prevention and therapy of corneal ulcers in patients with large-area thermal burns [J ] . Chin J Ophthalmol , 2022 , 58 ( 8 ): 592 - 597 .
Kaiser KP , Wissiak E , Daas L , et al . Use of in vivo corneal confocal microscopy to guide excimer laser with adjunctive mitomycin C for treatment of recalcitrant Acanthamoeba keratitis [J ] . Cornea , 2024 , 43 ( 5 ): 652 - 657 .
Du YL , Wang JS , Geng W , et al . Amniotic membrane transplantation combined with conjunctival flap covering surgery for the treatment of corneal perforations in fungal keratitis [J ] . Heliyon , 2023 , 9 ( 12 ): e22693 .
Zhang XM , Yang NY , Liu XJ , et al . Autonomic reinnervation and functional regeneration in autologous transplanted submandibular glands in patients with severe keratoconjunctivitis sicca [J ] . Int J Oral Sci , 2018 , 10 ( 2 ): 14 .
Ogawa M , Dogru M , Toriyama N , et al . Evaluation of the effect of moist chamber spectacles in patients with dry eye exposed to adverse environment conditions [J ] . Eye Contact Lens , 2018 , 44 ( 6 ): 379 - 383 .
Moon CW , Cho CH , Lee SB . Clinical comparative analysis of bacterial keratitis according to contact lens use:a retrospective study in a tertiary referral center of South Korea [J ] . Int Ophthalmol , 2023 , 43 ( 10 ): 3509 - 3521 .
Chen D , Xu DJ , Wu XD , et al . The efficacy of bandage contact lens in relieving the aggravation of dry eye disease after complicated cataract or/and IOL surgery [J ] . BMC Ophthalmol , 2024 , 24 ( 1 ): 141 .
Zheng Y , Zhai CB . Performance of bandage contact lens in patients post-ocular surgeries:a systematic literature review [J ] . Eye Contact Lens , 2023 , 49 ( 11 ): 449 - 458 .
Yoshikawa Y , Ueta M , Kinoshita S , et al . Long-term benefits of tear exchangeable limbal-rigid contact lens wear therapy in stevens- Johnson syndrome cases [J ] . Eye Contact Lens , 2023 , 49 ( 6 ): 247 - 253 .
Gervasio KA , Godfrey KJ , Marlow ED , et al . Prosthetic replacement of the ocular surface ecosystem(PROSE) versus standard of care for postsurgical lagophthalmos and exposure keratopathy:trends in visual outcomes [J ] . Ophthalmic Plast Reconstr Surg , 2019 , 35 ( 3 ): 281 - 285 .
Xu MM , Randleman JB , Chiu GB . Long-term descemetocele management with prosthetic replacement of the ocular surface ecosystem (PROSE) treatment [J ] . Eye Contact Lens , 2020 , 46 ( 2 ): e7 - e10 .
Schjerven Magno M , Olafsson J , Beining M , et al . Hot towels:the bedrock of Meibomian gland dysfunction treatment -A review [J ] . Cont Lens Anterior Eye , 2023 , 46 ( 2 ): 101775 .
Zhou XY , Shen Y , Shang JM , et al . Effects of warm compress on tear film,blink pattern and Meibomian gland function in dry eyes after corneal refractive surgery [J ] . BMC Ophthalmol , 2021 , 21 ( 1 ): 330 .
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Related Institution
Department of Health Statistics,College of Public Health,Chongqing Medical University
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