Effect of oral administration of vitamin D<sub>3</sub> on intestinal barrier function in patients after gastric cancer surgery

Wang Hong; Liang Chengqiang; Kang Dandan; Yuan Yanping; Ye Yafang; Lin Lihui; Li Lei

doi:10.13406/j.cnki.cyxb.003651

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Effect of oral administration of vitamin D₃ on intestinal barrier function in patients after gastric cancer surgery

Precision medicine in cancer and translational studies | 更新时间：2025-11-20

- Effect of oral administration of vitamin D₃ on intestinal barrier function in patients after gastric cancer surgery
- Journal of Chongqing Medical University Vol. 50, Issue 11, Pages: 1520-1524(2025)
- 作者机构：
  
  1.厦门大学附属中山医院临床营养科，厦门 361004
  2.厦门大学附属中山医院胃肠外科，厦门 361004
  3.厦门大学公共卫生学院分子疫苗学和分子诊断学国家重点实验室，厦门 361104
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.003651
  CLC： R459.3;R151.4
- Received：22 February 2024，
  
  Revised：2024-04-23，
  
  Accepted：11 November 2024，
  
  Published：28 November 2025
- 稿件说明：
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王鸿,梁成强,康丹丹等.口服维生素D₃对胃癌术后患者肠屏障功能的影响[J].重庆医科大学学报,2025,50(11):1520-1524.

Wang Hong,Liang Chengqiang,Kang Dandan,et al.Effect of oral administration of vitamin D₃ on intestinal barrier function in patients after gastric cancer surgery[J].Journal of Chongqing Medical University,2025,50(11):1520-1524.
王鸿,梁成强,康丹丹等.口服维生素D₃对胃癌术后患者肠屏障功能的影响[J].重庆医科大学学报,2025,50(11):1520-1524. DOI： 10.13406/j.cnki.cyxb.003651.

Wang Hong,Liang Chengqiang,Kang Dandan,et al.Effect of oral administration of vitamin D₃ on intestinal barrier function in patients after gastric cancer surgery[J].Journal of Chongqing Medical University,2025,50(11):1520-1524. DOI： 10.13406/j.cnki.cyxb.003651.

摘要

目的

分析口服维生素D

对胃癌术后患者肠屏障功能的影响，为胃癌患者围手术期营养治疗提供参考依据。

方法

采用便利抽样法，选取2021年6月至2023年5月厦门大学附属中山医院胃肠外科收治的80例胃癌患者，按随机数字法分为干预组和对照组。干预组术前给予口服维生素D

800 IU/d，持续14 d。分别于入院24 h内及术后1、4、7 d采用酶联免疫法检测 2 组患者血清25羟基维生素D

3、

肠屏障指标（D-乳酸、连蛋白）和炎症指标（C-反应蛋白、白细胞介素-6），比较2组的变化。

结果

最终纳入患者71例，其中干预组34例，对照组37例。术后1、4、7 d，干预组D-乳酸水平明显低于对照组（

=3.978，

=0.026；

=9.649，

=0.005；

=4.389，

=0.021）。术后4 d，干预组连蛋白水平明显低于对照组（

=3.198，

=0.035）。

结论

胃癌患者术前口服维生素D

可能会加速术后肠屏障功能康复。

Abstract

Objective

To investigate the effect of oral administration of vitamin D

on intestinal barrier function in patients after gastric cancer surgery，and to provide a reference for perioperative nutritional therapy in patients with gastric cancer.

Methods

The convenience sampling method was used to select 80 patients with gastric cancer who were admitted to Department of Gastrointestinal Surgery in a grade A tertiary hospital in Xiamen，China，from June 2021 to May 2023，and the patients were divided into intervention group and control group using a random number table. The patients in the intervention group we

re given oral administration of vitamin D

800 IU/d for 14 consecutive days before surgery. ELISA was used to measure the serum levels of 25-hydroxyvitamin D

［25（OH）D

］，intestinal barrier indicators（D-lactate，Zonulin），and inflammatory indicators（C-reactive protein，interleukin-6） within 24 hours after admission and on days 1，4，and 7 after surgery，and the changes in these indicators were compared between the two groups.

Results

A total of 71 patients were enrolled finally，with 34 in the intervention group and 37 in the control group. On days 1，4，and 7 after surgery，the intervention group had a significantly lower level of D-lactate than the control group（

=3.978，

=0.026；

=9.649，

=0.005；

=4.389，

=0.021）. On day 4 after surgery，the intervention group had a significantly lower level of Zonulin than the control group（

=3.198，

=0.035）.

Conclusion

Oral administration of vitamin D

before surgery may accelerate the recovery of intestinal barrier function in patients with gastric cancer.

关键词

Keywords

references

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Effect of oral administration of vitamin D3 on intestinal barrier function in patients after gastric cancer surgery

DOI：10.13406/j.cnki.cyxb.003651

摘要

Abstract

关键词

Keywords

references

Effect of oral administration of vitamin D₃ on intestinal barrier function in patients after gastric cancer surgery