四川大学华西第二医院妇产科出生缺陷与相关妇儿疾病教育部重点实验室,成都 610041
Received:28 August 2023,
Revised:2023-12-06,
Accepted:23 April 2024,
Published:28 November 2024
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张倩雯,刘兴会.内质网应激与疾病的关系研究进展[J].重庆医科大学学报,2024,49(11):1345-1349.
Zhang Qianwen,Liu Xinghui.Advances in the association between endoplasmic reticulum stress and human diseases[J].Journal of Chongqing Medical University,2024,49(11):1345-1349.
张倩雯,刘兴会.内质网应激与疾病的关系研究进展[J].重庆医科大学学报,2024,49(11):1345-1349. DOI: 10.13406/j.cnki.cyxb.003616.
Zhang Qianwen,Liu Xinghui.Advances in the association between endoplasmic reticulum stress and human diseases[J].Journal of Chongqing Medical University,2024,49(11):1345-1349. DOI: 10.13406/j.cnki.cyxb.003616.
内质网(endoplasmic reticulum,ER)是真核细胞的重要细胞器,负责绝大多数蛋白质的合成、加工及转运。为维持正常生理功能,细胞内质网对各种诱发因素极为敏感,通过激活自身应激状态缓解内质网压力以恢复稳态,持续或严重的内质网应激(endoplasmic reticulum stress,ERS)状态则促进细胞走向凋亡。目前发现ERS介导的细胞凋亡与疾病发生密切相关,本文将ERS相关信号通路、ERS与疾病的关系研究进展作一综述,为探索其参与疾病发生的机理、靶向干预ERS在疾病治疗中的作用提供新思路。
Endoplasmic reticulum is an important organelle of eukaryotic cells and is responsible for the synthesis,processing,and transportation of most proteins. In order to maintain the normal physiological function,endoplasmic reticulum is extremely sensitive to various predisposing factors and is restored to homeostasis by activating endoplasmic reticulum stress(ERS) to alleviate endoplasmic reticulum pressure,but persistent or severe ERS can promote cell apoptosis. Current studies have shown that ERS-mediated cell apoptosis is closely associated with the development of diseases. This article reviews the research advances in the association between ERS and diseases,in order to provide new ideas for exploring the mechanism and targeted intervention of ERS in diseases.
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