Correlation between low anti-nuclear antibody titers and pregnancy outcomes after frozen embryo transfer

Xu Shuning; Jia Zhu; Zhang Ning

doi:10.13406/j.cnki.cyxb.003612

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Correlation between low anti-nuclear antibody titers and pregnancy outcomes after frozen embryo transfer

Clinical research | 更新时间：2025-10-23

- Correlation between low anti-nuclear antibody titers and pregnancy outcomes after frozen embryo transfer
- Journal of Chongqing Medical University Vol. 49, Issue 11, Pages: 1474-1478(2024)
- 作者机构：
  
  1.山东中医药大学第一临床医学院，济南 250014
  2.山东中医药大学附属医院生殖中心，济南 250014
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.003612
  CLC： R114
- Received：19 July 2023，
  
  Revised：2024-06-22，
  
  Accepted：10 July 2024，
  
  Published：28 November 2024
- 稿件说明：
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徐书凝,贾珠,张宁.低滴度抗核抗体阳性与冻融胚胎移植妊娠结局的相关性研究[J].重庆医科大学学报,2024,49(11):1474-1478.

Xu Shuning,Jia Zhu,Zhang Ning.Correlation between low anti-nuclear antibody titers and pregnancy outcomes after frozen embryo transfer[J].Journal of Chongqing Medical University,2024,49(11):1474-1478.
徐书凝,贾珠,张宁.低滴度抗核抗体阳性与冻融胚胎移植妊娠结局的相关性研究[J].重庆医科大学学报,2024,49(11):1474-1478. DOI： 10.13406/j.cnki.cyxb.003612.

Xu Shuning,Jia Zhu,Zhang Ning.Correlation between low anti-nuclear antibody titers and pregnancy outcomes after frozen embryo transfer[J].Journal of Chongqing Medical University,2024,49(11):1474-1478. DOI： 10.13406/j.cnki.cyxb.003612.

摘要

目的

探讨低滴度抗核抗体（anti-nuclear antibody，ANA）阳性与冻融胚胎移植（frozen embryo transfer，FET）妊娠结局的相关性。

方法

筛选2019年1月至2022年1月于山东中医药大学附属医院生殖中心行FET患者的临床资料共1 562例，根据ANA检测结果分为低滴度阳性组155例和阴性组1 407例，将2组进行倾向性评分匹配后得到阳性组与对照组各48例，进行回顾性研究比较2组患者的妊娠结局。

结果

阳性组较对照组年龄（

=0.027）更大，临床妊娠率（

=0.008）、活产率（

=0.012）更低，差异有统计学意义，2组间异位妊娠率、流产率、早产率、单胎早产率、单胎出生体质量、单胎出生身长差异无统计学意义（

0.05），低滴度ANA阳性是FET临床妊娠（

=0.008）、活产（

=0.014）的独立影响因素，低滴度ANA阳性较ANA阴性患者FET更难获得临床妊娠（

=0.325，95%CI=0.140~0.750）和活产（

=0.342，95%CI=0.146~0.801）。

结论

低滴度ANA阳性与FET妊娠结局有关，对临床妊娠和活产有不利影响。

Abstract

Objective

To determine the correlation between low anti-nuclear antibody（ANA） titers and pregnancy outcomes after frozen embryo transfer（FET）.

Methods

Clinical data were collected from 1 562 patients undergoing

FET at the Reproductive Center of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine between January 2019 and January 2022. The patients were initially divided into the low-titer ANA-positive group（

=155） and ANA-negative group（

=1 407） based on their ANA test results. After propensity score matching，there were 48 patients each in the ANA-positive and ANA-negative groups. The pregnancy outcomes of the two groups were retrospectively analyzed.

Results

Patients in the ANA-positive group were older than those in the ANA-negative group（

=0.027），with significantly lower clinical pregnancy rate（

=0.008） and live birth rate（

=0.012）. There were no significant differences in ectopic pregnancy rate，miscarriage rate，premature birth rate，single premature birth rate，single birth weight，and single birth length between the two groups（

0.05）. Low-titer ANA positivity was an independent influencing factor for clinical pregnancy（

=0.008） and live birth（

=0.014） after FET. Clinical pregnancy（

=0.325，95%CI=0.140-0.750） and live birth（

=0.342，95%CI=0.146-0.801） after FET were more difficult for patients with low-titer ANAs compared to those without ANAs.

Conclusion

Low ANA titers are associated with FET pregnancy outcomes and have adverse effects on clinical pregnancy and live birth.

关键词

Keywords

references

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