Clinicopathological features and prognostic factors of nodal T-follicular helper cell lymphoma，angioimmunoblastic-type

He Juan; Wang Xingyu; He Hong; Wang Lixin; Tan Yanmei; Li Yuanxin; Huang Ying; Yu Kuai; Zhao Min; Xie Tao; Li Dan

doi:10.13406/j.cnki.cyxb.003547

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Clinicopathological features and prognostic factors of nodal T-follicular helper cell lymphoma，angioimmunoblastic-type

Clinical research | 更新时间：2025-10-21

- Clinicopathological features and prognostic factors of nodal T-follicular helper cell lymphoma，angioimmunoblastic-type
- Journal of Chongqing Medical University Vol. 49, Issue 7, Pages: 895-903(2024)
- 作者机构：
  
  1.重庆医科大学基础医学院病理学教研室,重庆 400016
  2.重庆医科大学附属第一医院第一分院消化内科,重庆 400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.003547
  CLC： R363
- Received：23 April 2024，
  
  Revised：2024-05-20，
  
  Accepted：30 May 2024，
  
  Published：28 July 2024
- 稿件说明：
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贺娟,王星宇,何鸿,等.淋巴结滤泡辅助T细胞淋巴瘤-血管免疫母细胞型临床病理特征和预后因素分析[J].重庆医科大学学报,2024,49(7):895-903.

He Juan,Wang Xingyu,He Hong,et al.Clinicopathological features and prognostic factors of nodal T-follicular helper cell lymphoma，angioimmunoblastic-type[J].Journal of Chongqing Medical University,2024,49(7):895-903.
贺娟,王星宇,何鸿,等.淋巴结滤泡辅助T细胞淋巴瘤-血管免疫母细胞型临床病理特征和预后因素分析[J].重庆医科大学学报,2024,49(7):895-903. DOI： 10.13406/j.cnki.cyxb.003547.

He Juan,Wang Xingyu,He Hong,et al.Clinicopathological features and prognostic factors of nodal T-follicular helper cell lymphoma，angioimmunoblastic-type[J].Journal of Chongqing Medical University,2024,49(7):895-903. DOI： 10.13406/j.cnki.cyxb.003547.

摘要

目的

探讨淋巴结滤泡辅助T细胞淋巴瘤-血管免疫母细胞型（nodal T-follicular helper cell lymphoma，angioimmuno-blastic-type，nTFHL-AI）临床病理特征和预后因素。

方法

回顾性分析63例nTFHL-AI患者临床信息，利用免疫组化（immunohistochemistry，IHC）、原位杂交（in situ hybridization，ISH）和抗原受体基因重排评估nTFHL-AI临床病理特征。使用Cox比例风险回归模型评估预后因素。

结果

免疫染色提示CD4阳性肿瘤细胞例数明显超过CD8（66% vs. 5%）。Epstein-Barr病毒（Epstein-Barr virus，EBV）编码的小RNA（EBV-encoded small RNA，EBER）阳性患者比EBER阴性患者更易表达CXCL13（

=0.006）。5年总体生存期（overall survival，OS）和无进展生存期（progression-free survival，PFS）分别为31%和16%。CXCL13阳性组OS和PFS显著优于CXCL13阴性组（

=0.003、

=0.04

0）。相反，BCL6阳性表达与较差的OS和PFS相关（

=0.026、

= 0.044），EBER阴性也与较差的OS和PFS相关（

=0.013、

=0.047）。多因素分析表明EBER阴性是OS和PFS独立不良预后因素（

=0.001、

=0.003）。

结论

CXCL13阳性预示nTFHL-AI患者预后良好，而BCL6阳性和EBER阴性与患者预后不良相关，并且EBER阴性是患者预后的独立危险因素。

Abstract

Objective

To investigate the clinicopathologic features and prognostic factors of nodal T-follicular helper cell lymphoma，angioimmunoblastic-type（nTFHL-AI）.

Methods

A retrospective analysis was performed for the clinical information of 63 patients with nTFHL-AI，and immunohistochemistry，

in situ

hybridization，and antigen receptor gene rearrangement were used to assess the clinicopathological features of nTFHL-AI. The

Cox

proportional hazards regression model was used to investigate prognostic factors.

Results

Immunostaining showed that the number of patients with dominant CD4-positive cells was significantly higher than that of patients with dominant CD8-positive cells（66% vs. 5%）. The patients who tested positive for Epstein-Barr virus-encoded small RNA （EBER） showed a higher probability for the expression of CXCL13 compared with their EBER-negative counterparts（

=0.006）. The 5-year overall survival（OS） rate and the progression-free survival（PFS） rate were 31% and 16%，respectively. The CXCL13-positive group had significantly better OS and PFS than the CXCL13-negative group（

=0.003 and 0.040）. On the contrary，positive BCL6 expression was associated with worse OS and PFS（

=0.026 and 0.044），and negative EBER was also associated with worse OS and PFS（

=0.013 and 0.047）. The multivariate analysis showed that negative EBER was an independent negative prognostic factor for both OS and PFS（

=0.001 and 0.003）.

Conclusion

Positive expression of CXCL13 indicates a favorable prognosis of nTFHL-AI patients，while positive BCL6 and negative EBER are associated with poor prognosis，and negative EBER is an independent risk factor for the prognosis of patients.

关键词

Keywords

references

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