Advances in invasive neuromodulation therapy for gait disturbance in Parkinson's disease

Zeng Zhitong; Huang Peng; Sun Bomin; Li Dianyou

doi:10.13406/j.cnki.cyxb.003486

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Advances in invasive neuromodulation therapy for gait disturbance in Parkinson's disease

Treatment of movement disorders | 更新时间：2025-10-22

- Advances in invasive neuromodulation therapy for gait disturbance in Parkinson's disease
- Journal of Chongqing Medical University Vol. 49, Issue 5, Pages: 548-551(2024)
- 作者机构：
  
  上海交通大学医学院附属瑞金医院神经外科，上海　200025
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.003486
  CLC： R742.5;R651
- Received：26 January 2024，
  
  Revised：2024-02-27，
  
  Accepted：29 February 2024，
  
  Published：28 May 2024
- 稿件说明：
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曾志童,黄鹏,孙伯民,等.帕金森病步态障碍的侵入性神经调控治疗进展[J].重庆医科大学学报,2024,49(5):548-551.

Zeng Zhitong,Huang Peng,Sun Bomin,et al.Advances in invasive neuromodulation therapy for gait disturbance in Parkinson's disease[J].Journal of Chongqing Medical University,2024,49(5):548-551.
曾志童,黄鹏,孙伯民,等.帕金森病步态障碍的侵入性神经调控治疗进展[J].重庆医科大学学报,2024,49(5):548-551. DOI： 10.13406/j.cnki.cyxb.003486.

Zeng Zhitong,Huang Peng,Sun Bomin,et al.Advances in invasive neuromodulation therapy for gait disturbance in Parkinson's disease[J].Journal of Chongqing Medical University,2024,49(5):548-551. DOI： 10.13406/j.cnki.cyxb.003486.

摘要

步态障碍是帕金森病（Parkinson's disease，PD）最常见的中轴症状之一，严重损害患者活动能力和生活质量。神经调控是PD步态障碍药物、运动和康复治疗之外的重要疗法，其中侵入性手术是常采用的调控手段。鉴于步态障碍的高发病率和现有疗法的疗效局限性，近年来侵入性神经调控出现了许多针对新靶点和新模式的研究。本文对侵入性神经调控在治疗PD步态障碍方面取得的一些进展进行综述和展望。

Abstract

Gait disturbance is one of the most common axial symptoms in Parkinson's disease（PD），and it severely impairs the mobility and quality of life of patients. Neuromodulation is an important therapy in addition to pharmacotherapy，exercise，and rehabilitation，among which invasive surgery is a commonly used modulation method. Due to the high prevalence rate of gait disturbance in PD and the limitations of existing therapies，studies for new targets and techniques have been conducted for invasive neuromodulation in recent years. This article reviews the advances and prospects of invasive neuromodulation in the treatment of gait disturbance in PD.

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references

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