Distribution and drug resistance of pathogenic bacteria in children with septic arthritis

Li Ziyu; Li Gefang; He Bo; Zhang Qun

doi:10.13406/j.cnki.cyxb.003449

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Distribution and drug resistance of pathogenic bacteria in children with septic arthritis

Clinical research | 更新时间：2025-10-22

- Distribution and drug resistance of pathogenic bacteria in children with septic arthritis
- Journal of Chongqing Medical University Vol. 49, Issue 3, Pages: 290-294(2024)
- 作者机构：
  
  重庆医科大学附属儿童医院骨科/国家儿童健康与疾病临床医学研究中心/儿童发育疾病研究教育部重点实验室/ 儿科学重庆市重点实验室，重庆　400014
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.003449
  CLC： R915.11
- Received：20 November 2023，
  
  Revised：2023-12-22，
  
  Accepted：03 January 2024，
  
  Published：28 March 2024
- 稿件说明：
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黎梓宇,李各芳,何波,等.儿童化脓性关节炎病原菌分布及耐药性分析[J].重庆医科大学学报,2024,49(3):290-294.

Li Ziyu,Li Gefang,He Bo,et al.Distribution and drug resistance of pathogenic bacteria in children with septic arthritis[J].Journal of Chongqing Medical University,2024,49(3):290-294.
黎梓宇,李各芳,何波,等.儿童化脓性关节炎病原菌分布及耐药性分析[J].重庆医科大学学报,2024,49(3):290-294. DOI： 10.13406/j.cnki.cyxb.003449.

Li Ziyu,Li Gefang,He Bo,et al.Distribution and drug resistance of pathogenic bacteria in children with septic arthritis[J].Journal of Chongqing Medical University,2024,49(3):290-294. DOI： 10.13406/j.cnki.cyxb.003449.

摘要

目的

分析171例儿童化脓性关节炎病原菌的分布及耐药性，为临床诊治提供依据。

方法

回顾重庆医科大学附属儿童医院2012年1月至2022年12月化脓性关节炎患者的细菌培养及药敏试验结果，分析其病原菌分布及耐药性特点。

结果

171例患者共检出病原菌82株，其中革兰氏阳性菌（Gram-positive G

）74株，革兰氏阴性菌（Gram-negative G

）8株。居前3位的细菌为金黄色葡萄球菌（54株，65.9%）、化脓性链球菌（7株，8.5%）、肺炎链球菌（5株，6.1%）。

2岁的患者主要病原菌为金黄色葡萄球菌和肺炎链球菌（15例，71.4%），2~5岁的患者主要病原菌为金黄色葡萄球菌（9例，81.8%），5岁以上的患者主要病原菌为金黄色葡萄球菌和化脓性链球菌（40例，88.9%）。所有G

对万古霉素和利奈唑胺耐药率0%，金黄色葡萄球菌对苯唑西林、阿莫西林/克拉维酸、头孢克洛、氟氯西林的耐药率

30%，化脓性链球菌对青霉素耐药率0%，肺炎链球菌对青霉素、头孢曲松耐药率20%。所有G

对头孢他啶、头孢吡肟、左氧氟沙星、环丙沙星、亚胺培南耐药率均为0%。

结论

临床医师在治疗化脓性关节炎时可根据所在区域的主要病原菌及其耐药特点结合患者年龄分布特征选择适宜的抗菌药物。

Abstract

Objective

To analyze the distribution and drug resistance of pathogenic bacteria in 171 children with septic arthritis，and to provide a basis for clinical diagnosis and treatment.

Methods

Based on bacterial culture and drug sensitivity test results，we analyzed the distribution and drug resistance of pathogenic bacteria in patients with septic arthritis in Children’s Hospital of Chongqing Medical University from January 2012 to December 2022.

Results

A total of 82 strains of pathogenic bacteria were detected in 171 patients，including 74 Gram-positive （G

） and 8 Gram-negative strains（G

）. The top three bacteria were

Staphylococcus aureus

（54 strains，65.9%），

Streptococcus pyogenes

（7 strains，8.5%），and

Streptococcus pneumoniae

（5 strains，6.1%）. The predominant pathogens were

Staphylococcus aureus

and

Streptococcus pneumoniae

in patients under two years of age （15 cases，71.4%），

Staphylococcus aureus

in patients between two and five years of age（9 cases，81.8%），and

Staphylococcus aureus

and

Streptococcus pyogenes

in patients over five years of age（40 cases，88.9%）. For all G

bacteria，the rates of resistance to vancomycin and linezolid were 0%. The resistance rates of

Staphylococcus aureus

to benzoxacillin，amoxicillin/clavulanic acid，cefaclor，and flucloxacillin were

30%. The resistance rate of

Streptococcus pyogenes

to penicillin was 0%.

Streptococcus pneumoniae

was 20% resistant to penicillin and ceftriaxone. All G

bacteria were 0% resistant to ceftazidime，cefepime，levofloxacin，ciprofloxacin，and imipenem.

Conclusion

Clinicians should choose appropriate antimicrobial drugs to treat septic arthritis according to the main pathogens and their resistance characteristics in local regions as well as the age distribution of patients.

关键词

Keywords

references

Cohen E ， Katz T ， Rahamim E ， et al . Septic arthritis in children：updated epidemiologic，microbiologic，clinical and therapeutic correlations [J ] . Pediatr Neonatol ， 2020 ， 61 （ 3 ）： 325 - 330 ．

Arieli MM ， Fowler ML ， Lieber SB ， et al . The profile of the causative organisms which lead to septic arthritis of native joints over the last two decades in a single tertiary medical center in the east coast of the United States [J ] . Int J Clin Pract ， 2021 ， 75 （ 12 ）： e15003 ．

Aitkens L ， Winn M ， Waller JL ， et al . Septic arthritis in the end-stage renal disease population [J ] . J Investig Med ， 2022 ， 70 （ 2 ）： 383 - 390 ．

Cohen D ， Natshe A ， Ben Chetrit E ， et al . Synovial fluid culture：agar plates vs . blood culture bottles for microbiological identification [J ] . Clin Rheumatol ， 2020 ， 39 （ 1 ）： 275 - 279 ．

Nossent JC ， Raymond WD ， Keen HI ， et al . Septic arthritis in children：a longitudinal population-based study in western Australia [J ] . Rheumatol Ther ， 2021 ， 8 （ 2 ）： 877 - 888 ．

Jeyanthi JC ， Yi KM ， Jr Allen JC ， et al . Epidemiology and outcome of septic arthritis in childhood：a 16-year experience and review of literature [J ] . Singapore Med J ， 2022 ， 63 （ 5 ）： 256 - 262 ．

卓　超，钟南山 . 骨关节外科相关感染国外指南述评 [J ] . 中华关节外科杂志（电子版）， 2015 ， 9 （ 1 ）： 128 - 132 ．

Zhuo C ， Zhong NS . Review of foreign guidelines on osteoarticular surgery-related infections [J ] . Chin J Jt Surg Electron Ed ， 2015 ， 9 （ 1 ）： 128 - 132 ．

He M ， Arthur Vithran DT ， Pan LY ， et al . An update on recent progress of the epidemiology，etiology，diagnosis，and treatment of acute septic arthritis：a review [J ] . Front Cell Infect Microbiol ， 2023 ， 13 ： 1193645 ．

Zhang TJ ， Yu S ， Lv X ， et al . Paediatric osteomyelitis and septic arthritis pathogen distribution and antimicrobial resistance in a single centre：a 15-year retrospective analysis [J ] . J Trop Pediatr ， 2022 ， 68 （ 3 ）： fmac038 ．

Faust SN ， Clark J ， Pallett A ， et al . Managing bone and joint infection in children [J ] . Arch Dis Child ， 2012 ， 97 （ 6 ）： 545 - 553 ．

崔硬铁，冯彦华，王　康，等 . 儿童髋化脓性关节炎病原体及药物敏感分析 [J ] . 国际生物医学工程杂志， 2017 ， 40 （ 6 ）： 432 - 436 ．

Cui YT ， Feng YH ， Wang K ， et al . Pathogens and drug susceptibility test of septic arthritis of hip in children [J ] . Int J Biomed Eng ， 2017 ， 40 （ 6 ）： 432 - 436 ．

Ross JJ ， Saltzman CL ， Carling P ， et al . Pneumococcal septic arthritis：review of 190 cases [J ] . Clin Infect Dis ， 2003 ， 36 （ 3 ）： 319 - 327 ．

Congedi S ， Minotti C ， Giaquinto C ， et al . Acute infectious osteomyelitis in children：new treatment strategies for an old enemy [J ] . World J Pediatr ， 2020 ， 16 （ 5 ）： 446 - 455 ．

Pääkkönen M . Septic arthritis in children：diagnosis and treatment [J ] . Pediatric Health Med Ther ， 2017 ， 8 ： 65 - 68 ．

郭　宇，梁玉龙，魏　莹，等 . 儿童化脓性骨与关节感染的细菌耐药分析 [J ] . 国际检验医学杂志， 2021 ， 42 （ 13 ）： 1618 - 1621 ．

Guo Y ， Liang YL ， Wei Y ， et al . Bacterial drug resistance analysis of suppurative bone and joint infection in children [J ] . Int J Lab Med ， 2021 ， 42 （ 13 ）： 1618 - 1621 ．

Lade H ， Joo HS ， Kim JS . Molecular basis of non-β-lactam antibiotics resistance in Staphylococcus aureus [J ] . Antibiotics ， 2022 ， 11 （ 10 ）： 1378 ．

Chang C ， Lo W ， Chan M ， et al . An investigation of vancomycin minimum inhibitory concentration creep among [J ] . Journal of Microbiology Immunology & Infection ， 2017 , 50 ( 3 ）: 362 - 369 .

Siemens N ， Lütticken R . Streptococcus pyogenes （“group A Streptococcus ”），a highly adapted human pathogen-potential implications of its virulence regulation for epidemiology and disease management [J ] . Pathogens ， 2021 ， 10 （ 6 ）： 776 ．

易　进．化脓性链球菌SLO对破骨细胞分化及其功能影响的研究 [D ] . 重庆：陆军军医大学， 2018 ．

Yi J . Effects of Streptococcus pyogenes SLO on osteoclast differentiation and function [D ] . ChongQing ： Army Medical University ， 2018 ．

Trobisch A ， Schweintzger NA ， Kohlfürst DS ， et al . Osteoarticular infections in pediatric hospitals in Europe：a prospective cohort study from the EUCLIDS consortium [J ] . Front Pediatr ， 2022 ， 10 ： 744182 ．

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