Li Mengfen,Tang Xiaojun,Wang Shaomei,et al.Interaction between lifestyle and family history on cardiometabolic diseases[J].Journal of Chongqing Medical University,2024,49(1):31-36.
Li Mengfen,Tang Xiaojun,Wang Shaomei,et al.Interaction between lifestyle and family history on cardiometabolic diseases[J].Journal of Chongqing Medical University,2024,49(1):31-36. DOI: 10.13406/j.cnki.cyxb.003400.
Interaction between lifestyle and family history on cardiometabolic diseases
=1.22,95%CI=0.86~1.73),也不存在相加交互作用,相对超危险度比(the relative excess risk due to interaction,RERI)、归因比(attributable risk percent,AP)、交互作用指数(S)分别为0.69(95%CI=-3.98~5.36)、0.21(95%CI=-0.95~1.37)、1.44(95%CI=0.16~13.03)。生活方式不健康且有家族史者,患心血管代谢疾病的风险高于生活方式健康且无家族史者(
To investigate the influence of lifestyle and family history of cardiometabolic diseases on the risk of cardiometabolic diseases and the interaction between lifestyle and family history,and to guide disease prevention and control.
Methods
2
A total of 3009 permanent residents,aged 30-79 years,in Hechuan District were selected as subjects according to the inclusion and exclusion criteria,and a questionnaire survey,physical examination,and laboratory tests were performed. SPSS 26.0 was used to perform the chi-square test and the multivariate logistic regression analysis,and the multiplicative model and the additive model were used to investigate the interaction between lifestyle and family history on the onset of cardiometabolic diseases.
Results
2
There was neither multiplicative interaction(
OR
int
=1.22,95%CI=0.86-1.73) nor additive interaction between lifestyle and family history on cardiometabolic diseases,with a relative excess risk due to interaction of 0.69(95%CI=-3.98 to 5.36),an attributable proportion of 0.21(95%CI=-0.95 to 1.37),and a synergy index of 1.44(95%CI=0.16-13.03). The individuals with an unhealthy lifestyle and a family history of cardiometabolic diseases had a higher risk of cardiometabolic diseases than those with a healthy lifestyle and no fam
ily history(odds ratio[
OR
]
=3.26,95%CI=2.52-4.23),and male individuals(
OR
=5.16,95%CI=3.12-8.52) had a higher risk than female individuals(
OR
=2.72,95%CI=1.96-3.77).
Conclusion
2
There is no interaction between lifestyle and family history on the risk of cardiometabolic diseases,but there is a combined effect. For individuals with such family history,maintaining a healthy lifestyle may help to control cardiometabolic diseases.
Xu QQ , Yan YF , Chen H , et al . Predictions of achievement of Sustainable Development Goal to reduce age-standardized mortality rate of four major non-communicable diseases by 2030 in China [J ] . Chin J Epidemiol , 2022 , 43 ( 6 ): 878 - 884 .
Geng Y , Jie W , Zhang SJ , et al . Research progress on epidemic status and prevention of chronic diseases comorbidity [J ] . Chin J Prev Contr Chronic Dis , 2023 , 31 ( 1 ): 71 - 75 .
Han YT , Sun ZJ , Lyu J , et al . Progress in research on the association between lifestyle and cardiometabolic multimorbidity [J ] . Chin J Dis Contr Prev , 2021 , 25 ( 3 ): 266 - 270 .
Wang XL . Epidemiological analysis of cardiovascular metabolic diseases in China and the correlation between long-term weight change and metabolic health [D ] . Beijing : Chinese Academy of Medical Sciences , 2022 .
Xiao M , Tang XJ , Zhang F , et al . Association between self-reported snoring and hypertension among Chinese Han population aged 30-79 in Chongqing,China [J ] . Environ Health Prev Med , 2020 , 25 ( 1 ): 78 .
Zhao X , Hong F , Yin JZ , et al . Cohort profile:the China multi-ethnic cohort(CMEC) study [J ] . Int J Epidemiol , 2021 , 50 ( 3 ): 721-721l .
Li TT . Construction of natural population cohort information management platform based on precision medicine [J ] . Mod Inf Technol , 2020 , 4 ( 6 ): 124 - 126 .
Qiu H , Yu DX , Xie LY , et al . Interaction between continuous variables in logistic regression model [J ] . Chin J Epidemiol , 2010 , 31 ( 7 ): 812 - 814 .
Andersson T , Alfredsson L , Källberg H , et al . Calculating measures of biological interaction [J ] . Eur J Epidemiol , 2005 , 20 ( 7 ): 575 - 579 .
Han YT , Hu YZ , Yu CQ , et al . Lifestyle,cardiometabolic disease,and multimorbidity in a prospective Chinese study [J ] . Eur Heart J , 2021 , 42 ( 34 ): 3374 - 3384 .
Zhang DD , Tang X , Shen P , et al . Multimorbidity of cardiometabolic diseases:prevalence and risk for mortality from one million Chinese adults in a longitudinal cohort study [J ] . BMJ Open , 2019 , 9 ( 3 ): e024476 .
Xiu ZR , Luo L , Wu J , et al . Effect and interaction of family history of diabetes mellitus and hypertension on abnormal glucose metabolism [J ] . Chin J Diabetes Mellit , 2023 , 15 ( 5 ): 416 - 420 .
Tang HX , Wang J , Zeng Y , et al . Interaction effect of smoking and family history of stroke on stroke morbidity [J ] . Pract Prev Med , 2023 , 30 ( 7 ): 781 - 784 .
Li RC , Rong YM , Li YL , et al . Impact of interaction between family history of diabetes and abnormal waist-to-height ratio on risk of type 2 diabetes mellitus [J ] . Chin J Diabetes , 2018 , 10 ( 9 ): 606 - 610 .
Zhang Y , Tang HX , Ling YS , et al . Study on the correlation between family history of diabetes and central obesity on diabetes prevalence in a district of Chongqing [J ] . Chin Prim Heath Care , 2022 , 36 ( 5 ): 38 - 41 .