Value of vestibular evoked myogenic potentials and electrocochleography in predicting the prognosis of acute low-frequency sensorineural hearing loss

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Value of vestibular evoked myogenic potentials and electrocochleography in predicting the prognosis of acute low-frequency sensorineural hearing loss

Clinical research | 更新时间：2025-10-22

- Value of vestibular evoked myogenic potentials and electrocochleography in predicting the prognosis of acute low-frequency sensorineural hearing loss
- Journal of Chongqing Medical University Vol. 48, Issue 10, Pages: 1255-1260(2023)
- 作者机构：
  
  重庆医科大学附属第一医院耳鼻咽喉科，重庆 400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.003357
  CLC： R764.3
- Received：26 June 2023，
  
  Revised：2023-07-04，
  
  Accepted：17 August 2023，
  
  Published：28 October 2023
- 稿件说明：
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江黎珠,孙平,宗小芳.前庭诱发肌源性电位和耳蜗电图对急性低频感音神经性聋预后的预判价值[J].重庆医科大学学报,2023,48(10):1255-1260.

Jiang Lizhu,Sun Ping,Zong Xiaofang.Value of vestibular evoked myogenic potentials and electrocochleography in predicting the prognosis of acute low-frequency sensorineural hearing loss[J].Journal of Chongqing Medical University,2023,48(10):1255-1260.
江黎珠,孙平,宗小芳.前庭诱发肌源性电位和耳蜗电图对急性低频感音神经性聋预后的预判价值[J].重庆医科大学学报,2023,48(10):1255-1260. DOI： 10.13406/j.cnki.cyxb.003357.

Jiang Lizhu,Sun Ping,Zong Xiaofang.Value of vestibular evoked myogenic potentials and electrocochleography in predicting the prognosis of acute low-frequency sensorineural hearing loss[J].Journal of Chongqing Medical University,2023,48(10):1255-1260. DOI： 10.13406/j.cnki.cyxb.003357.

摘要

目的

2

探讨前庭诱发肌源性电位和耳蜗电图对急性低频感音神经性聋（acute low frequency sensorineural hearing loss，ALFHL）预后的预判价值。

方法

2

收集 2020年1月至2022年6月在重庆医科大学附属第一医院耳鼻咽喉科住院的60例单侧首次ALFHL患者的病历资料。所有患者入院后行耳蜗电图（electrocochleography ，EcochG）、眼性前庭诱发肌源性电位（ocular vestibular evoked myogenic potential，oVEMP）、颈性前庭诱发肌源性电位（cervical vestibular evoked myogenic potential，cVEMP）检查；于治疗开始前，治疗后1周、2周和1月行纯音测听检测。EcochG-SP/AP>0.4和SP/AP面积比>1.92为异常。cVEMP和oVEMP波形引出与否，振幅比（≤1.61）和不对称比（≤0.29），其中任何一项异常为异常。各组间率的比较采用卡方检验、McNemar检验和Mann-Whitney检验，ALFHL预后的危险因素分析采用单因素和多因素二元 logistic 回归分析。

结果

2

60例ALFHL患者中，EcochG、cVEMP和oVEMP异常率分别为26.7%、23.3%和35.0%。EcochG和oVEMP异常率与患者年龄、性别、听力损失水平、治疗起始时间、有无伴耳闷和头晕无相关性。cVEMP异常率在听力损失

>

40dB HL的ALFHL中显著高于≤40 dB HL的患者（

P

<

0.05）。EcochG、cVEMP和oVEMP异常的患者听力提高程度均低于其正常的患者（

P

<

0.05）。单因素二元logistic回归分析发现，异常的EcochG、cVEMP和oVEMP是ALFHL不痊愈的危险因素（均

P

<

0.05），而多因素二元logistic回归分析发现仅cVEMP和oVEMP是ALFHL不痊愈的独立危险因素（均

P

<

0.05）。

结论

2

异常的cVEMP和oVEMP是ALFHL患者不痊愈的独立危险因素，这可能与ALFHL患者球囊和椭圆囊内淋巴积水严重不易消退有关。检查cVEMP和oVEMP发现其异常，提示ALFHL患者不痊愈风险大。

Abstract

Objective

2

To investigate the value of vestibular evoked myogenic potentials（VEMPs） and electrocochleography（EcochG） in predicting the prognosis of acute low-frequency sens

orineural hearing loss（ALFHL）

.

Methods

2

Medical records were collected from 60 patients with first-time unilateral ALFHL who were hospitalized in Department of Otolaryngology，The First Affiliated Hospital of Chongqing Medical University from January 2020 to June 2022. All patients underwent the examinations of EcochG，ocular vestibular evoked myogenic potentials（oVEMP），and cervical vestibular evoked myogenic potentials（cVEMP） after admission，and pure tone audiometry was performed before treatment and at 1 week，2 weeks，and 1 month after treatment. An EcochG SP/AP ratio of >0.4 and an SP/AP area ratio of >1.92 were considered abnormal. If cVEMP and oVEMP were not elicited or if the amplitude ratio was ≤1.61 and the asymmetry ratio was ≤0.29，it was considered abnormal. The chi-square test，the McNemar test，and the Mann-Whitney test were used for comparison of rates between groups，and univariate and multivariate binary logistic regression analyses were used to identify the risk factors for the prognosis of ALFHL.

Results

2

The abnormal rates of EcochG，cVEMP，and oVEMP were 26.7%，23.3%，and 35.0%，respectively，in the 60 patients with ALFHL. The abnormal rates of EcochG and oVEMP showed no correlation with age，sex，hearing loss level，starting time of treatment，aural fullness，and dizziness. The abnormal rate of cVEMP in the ALFHL patients with hearing loss

>

40 dB HL was significantly higher than that in the patients with hearing loss ≤40 dB HL（

P

<

0.05）. The patients with abnormal EcochG，cVEMP，and oVEMP had a significantly lower degree of hearing improvement than those with normal results（

P

<

0.05）. The univariate binary logistic regression analysis showed that abnormal EcochG，cVEMP，and oVEMP were risk factors for non-recovery of ALFHL（all

P

<

0.05），while the multivariate binary logistic regression analysis showed that cVEMP and oVEMP were independent risk factors for non-reco

very of ALFHL（both

P

<

0.05）.

Conclusion

2

Abnormal cVEMP and oVEMP are independent risk factors for non-recovery of ALFHL，which may be associated with the difficulty in the regression of hydrops in the saccule and utricle of ALFHL patients. The detection of abnormal cVEMP and oVEMP indicates a high risk of non-recovery in patients with ALFHL.

关键词

Keywords

references

Imamura S ， Nozawa I ， Imamura M ， et al . Clinical observations on acute low-tone sensorineural hearing loss. Survey and analysis of 137 patients [J ] . Ann Otol Rhinol Laryngol ， 1997 ， 106 （ 9 ）： 746 - 750 .

Yamasoba T ， Sugasawa M ， Kikuchi S ， et al . An electrocochleographic study of acute low-tone sensorineural hearing loss [J ] . Eur Arch Otorhinolaryngol ， 1993 ， 250 （ 7 ）： 418 - 422 .

Diao TX ， Chen YR ， Jing YY ， et al . Clinical characteristics and prognosis of acute low-frequency hearing loss and ascending sensorineural sudden sensorineural hearing loss [J ] . Front Neurosci ， 2022 ， 16 ： 1076109 .

Inui H ， Sakamoto T ， Ito T ， et al . Magnetic resonance imaging of the endolymphatic space in patients with acute low-tone sensorineural hearing loss [J ] . Auris Nasus Larynx ， 2019 ， 46 （ 6 ）： 859 - 865 .

Peng AQ ， Hu JJ ， Wang Q ， et al . Modulation of hearing function following the downgrading or upgrading of endolymphatic hydrops in Meniere’s disease patients with endolymphatic duct blockage [J ] . PLoS One ， 2020 ， 15 （ 10 ）： e0240315 .

Murofushi T . Clinical application of vestibular evoked myogenic potential（VEMP） [J ] . Auris Nasus Larynx ， 2016 ， 43 （ 4 ）： 367 - 376 .

Jiang LZ ， Qian Y . The value of vestibular evoked myogenic potential and electrocochleography in unexplained aural fullness [J ] . Acta Otolaryngol ， 2022 ， 142 （ 3/4 ）： 225 - 228 .

Park MJ ， Kim SH ， Kim SS ， et al . Clinical characteristics and short-term outcomes of acute low frequency sensorineural hearing loss with Vertigo [J ] . Clin Exp Otorhinolaryngol ， 2018 ， 11 （ 2 ）： 96 - 101 .

Choi HG ， Park KH ， Seo JH ， et al . Clinical and audiologic characteristics of acute low-tone sensorineural hearing loss: therapeutic response and prognosis [J ] . Korean J Audiol ， 2011 , 15 : 8 - 14 .

Fushiki H ， Junicho M ， Kanazawa Y ， et al . Prognosis of sudden low-tone loss other than acute low-tone sensorineural hearing loss [J ] . Acta Otolaryngol ， 2010 ， 130 （ 5 ）： 559 - 564 .

Im GJ ， Kim SK ， Choi J ， et al . Analysis of audio-vestibular assessment in acute low-tone hearing loss [J ] . Acta Otolaryngol ， 2016 ， 136 （ 7 ）： 649 - 654 .

Guo XD ， Wang QL ， Mei XS ， et al . Value of videonystagmography and electrocochleography in prognosis prediction of patients with acute low-tone sensorineural hearing loss [J ] . Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi ， 2016 ， 30 （ 10 ）： 767 - 769 ； 773 .

Wu CL ， Young YH . Vestibular evoked myogenic potentials in acute low-tone sensorineural hearing loss [J ] . Laryngoscope ， 2004 ， 114 （ 12 ）： 2172 - 2175 .

de Waele C ， Huy PT ， Diard JP ， et al . Saccular dysfunction in Meniere’s disease [J ] . Am J Otol ， 1999 ， 20 （ 2 ）： 223 - 232 .

Egami N ， Ushio M ， Yamasoba T ， et al . The diagnostic value of vestibular evoked myogenic potentials in patients with Meniere’s disease [J ] . J Vestib Res ， 2013 ， 23 （ 4/5 ）： 249 - 257 .

Wang CT ， Fang KM ， Young YH ， et al . Vestibular-evoked myogenic potential in the prediction of recovery from acute low-tone sensorineural hearing loss [J ] . Ear Hear ， 2010 ， 31 （ 2 ）： 289 - 295 .

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