Relationship between monocyte-to-lymphocyte ratio and lower extremity arterial disease in patients with diabetic foot disease

He Yu; Lei Xiaotian; Leng Weiling; Zhang Xing; Liang Ziwen

doi:10.13406/j.cnki.cyxb.003322

您当前的位置：

首页 >

文章列表页 >

Relationship between monocyte-to-lymphocyte ratio and lower extremity arterial disease in patients with diabetic foot disease

Hypothalamic pituitary gland and wound repair diseases | 更新时间：2025-10-21

- Relationship between monocyte-to-lymphocyte ratio and lower extremity arterial disease in patients with diabetic foot disease
- Journal of Chongqing Medical University Vol. 48, Issue 9, Pages: 1063-1068(2023)
- 作者机构：
  
  陆军军医大学第一附属医院内分泌科，重庆 400038
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.003322
  CLC： R587.2
- Received：30 May 2023，
  
  Revised：2023-07-01，
  
  Accepted：25 July 2023，
  
  Published：28 September 2023
- 稿件说明：
移动端阅览
何雨,雷小添,冷蔚玲,等.单核细胞/淋巴细胞比值与糖尿病足患者下肢动脉病变的相关性研究[J].重庆医科大学学报,2023,48(9):1063-1068.

He Yu,Lei Xiaotian,Leng Weiling,et al.Relationship between monocyte-to-lymphocyte ratio and lower extremity arterial disease in patients with diabetic foot disease[J].Journal of Chongqing Medical University,2023,48(9):1063-1068.
何雨,雷小添,冷蔚玲,等.单核细胞/淋巴细胞比值与糖尿病足患者下肢动脉病变的相关性研究[J].重庆医科大学学报,2023,48(9):1063-1068. DOI： 10.13406/j.cnki.cyxb.003322.

He Yu,Lei Xiaotian,Leng Weiling,et al.Relationship between monocyte-to-lymphocyte ratio and lower extremity arterial disease in patients with diabetic foot disease[J].Journal of Chongqing Medical University,2023,48(9):1063-1068. DOI： 10.13406/j.cnki.cyxb.003322.

摘要

目的

探讨单核细胞/淋巴细胞比值（monocytes to lymphocytes ratio，MLR）与糖尿病足患者下肢动脉病变（lower extremity arterial disease，LEAD）的相关性。

方法

选取2020年4月至2023年4月于陆军军医大学第一附属医院住院治疗的2 型糖尿病足患者243例，分为下肢动脉病变组（LEAD，

=103）和非下肢动脉病变组（non-lower extremity arterial disease，NLEAD，

=140），分析MLR与LEAD的相关性。

结果

LEAD组MLR显著高于NLEAD组［0.46（0.29，0.63） vs. 0.38（0.26，0.58）（

0.05）］。logistic回归分析结果显示，MLR、年龄、胆固醇、血肌酐是糖尿病足患者发生下肢血管病变的影响因素（

0.05）。受试者工作特征曲线分析表明，MLR预测糖尿病足患者下肢血管病变的最佳切点为0.34，敏感度和特异度分别为69.9%和46.4%。

结论

MLR与2型糖尿病足患者LEAD的发生相关。

Abstract

Objective

To evaluate the relationship between the monocyte-to-lymphocyte ratio（MLR） and lower extremity arterial disease（LEAD） in patients with diabetic foot disease.

Methods

We included a total of 243 patients with type 2 diabetic foot problems hospitalized in The First Affiliated Hospital of Army Medical University from April 2020 to April 2023. They were divided into LEAD group（

=103） and non-LEAD group（

=140） to analyze the relationship between MLR and LEAD.

Results

The MLR in the LEAD group was significantly higher than that in the non-LEAD group（0.46［0.29，0.63］ vs. 0.38［0.26，0.58］，

0.05）. The logistic regression analysis showed that MLR，age，serum cholesterol，and serum creatinine were risk factors for LEAD in patients with diabetic foot disease（

0.05）. The receiver operating characteristic curve analysis showed that the optimal cut-off point for MLR predicting lower extremity arterial disease in patients with diabetic foot problems was 0.34，with sensitivity and specificity being 69.9% and 46.4%，respectively.

Conclusion

MLR is associated with the development of LEAD in patients with type 2 diabetic foot disease.

关键词

Keywords

references

Li Y ， Teng D ， Shi X ， et al . Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association：national cross sectional study [J ] . Bmj ， 2020 ， 369 ： m997 .

Schaper NC ， van Netten JJ ， Apelqvist J ， et al . Practical Guidelines on the prevention and management of diabetic foot disease（IWGDF 2019 update) [J ] . Diabetes Metab Res Rev ， 2020 ， 36 Suppl 1 ： e3266 .

Zhang X ， Ran X ， Xu Z ， et al . Epidemiological characteristics of lower extremity arterial disease in Chinese diabetes patients at high risk：a prospective，multicenter，cross-sectional study [J ] . J Diabetes Complications ， 2018 ， 32 （ 2 ）： 150 - 156 .

Halim M ， Halim A . The effects of inflammation，aging and oxidative stress on the pathogenesis of diabetes mellitus（type 2 diabetes) [J ] . Diabetes Metab Syndr ， 2019 ， 13 （ 2 ）： 1165 - 1172 .

Wolf D ， Ley K . Immunity and Inflammation in Atherosclerosis [J ] . Circ Res ， 2019 ， 124 （ 2 ）： 315 - 327 .

Kose N ， Akin F ， Yildirim T ， et al . The association between the lymphocyte-to-monocyte ratio and coronary artery disease severity in patients with stable coronary artery disease [J ] . Eur Rev Med Pharmacol Sci ， 2019 ， 23 （ 6 ）： 2570 - 2575 .

Mao X ， Yu Q ， Liao Y ， et al . Lymphocyte-to-monocyte ratio is independently associated with progressive infarction in patients with acute ischemic stroke [J ] . Biomed Res Int ， 2022 ， 2022 ： 2290524 .

Jaaban M ， Zetoune AB ， Hesenow S ， et al . Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as novel risk markers for diabetic nephropathy in patients with type 2 diabetes [J ] . Heliyon ， 2021 ， 7 （ 7 ）： e07564 .

Zeng J ， Chen M ， Feng Q ， et al . The Platelet-to-lymphocyte ratio predicts diabetic retinopathy in type 2 diabetes mellitus [J ] . Diabetes Metab Syndr Obes ， 2022 ， 15 ： 3617 - 3626 .

中国医疗保健国际交流促进会糖尿病足病分会，国际血管联盟中国分部糖尿病足病专家委员会 . 中国糖尿病足诊治指南 [J ] . 中国临床医生杂志， 2020 ， 48 （ 1 ）： 19 - 27 .

China International Exchange and Promotive Association for Medical and Health Care Diabetic Foot Disease Branch ， International Vascular Union Chinese Branch Diabetic Foot Disease Expert Committee . Guidelines for diagnosis and treatment of Diabetic foot in China [J ] . J Chinese Journal for Clinicians ， 2020 ， 48 （ 1 ）： 19 - 27 .

Medzhitov R . Origin and physiological roles of inflammation [J ] . Nature ， 2008 ， 454 （ 7203 ）： 428 - 435 .

Teperman J ， Carruthers D ， Guo Y ， et al . Relationship between neutrophil-lymphocyte ratio and severity of lower extremity peripheral artery disease [J ] . Int J Cardiol ， 2017 ， 228 ： 201 - 204 .

Shi Y ， Vanhoutte P M . Macro- and microvascular endothelial dysfunction in diabetes [J ] . J Diabetes ， 2017 ， 9 （ 5 ）： 434 - 449 .

Balta S ， Demırer Z ， Aparci M ， et al . The lymphocyte-monocyte ratio in clinical practice [J ] . J Clin Pathol ， 2016 ， 69 （ 1 ）： 88 - 89 .

Ji H ， Li Y ， Fan Z ， et al . Monocyte/lymphocyte ratio predicts the severity of coronary artery disease：a syntax score assessment [J ] . BMC Cardiovasc Disord ， 2017 ， 17 （ 1 ）： 90 .

Ren H ， Liu X ， Wang L ， et al . Lymphocyte-to-monocyte ratio：a novel predictor of the prognosis of acute ischemic stroke [J ] . J Stroke Cerebrovasc Dis ， 2017 ， 26 （ 11 ）： 2595 - 2602 .

中华医学会糖尿病学分会 . 中国2型糖尿病防治指南（2020年版) [J ] . 中华糖尿病杂志， 2021 ， 13 （ 4 ）： 95 .

Chinese Diabetes Society . Guideline for the prevention and treatment of type 2 diabetes mellitus in China（2020edition) [J ] . J Chin J Diabetes Mellitus ， 2021 ， 13 （ 4 ）： 95 .

Cosarca MC ， Hălmaciu I ， Muresan AV ， et al . Neutrophil‑to‑lymph-ocyte，platelet‑to‑lymphocyte and lymphocyte‑to‑monocyte ratios are associated with amputation rates in patients with peripheral arterial disease and diabetes mellitus who underwent revascularization：a Romanian regional center study [J ] . Exp Ther Med ， 2022 ， 24 （ 5 ）： 703 .

Demirdal T ， Sen P . The significance of neutrophil-lymphocyte ratio，platelet-lymphocyte ratio and lymphocyte-monocyte ratio in predicting peripheral arterial disease，peripheral neuropathy，osteomyelitis and amputation in diabetic foot infection [J ] . Diabetes Res Clin Pract ， 2018 ， 144 ： 118 - 125 .

Libby P ， Okamoto Y ， Rocha VZ ， et al . Inflammation in atherosclerosis：transition from theory to practice [J ] . Circ J ， 2010 ， 74 （ 2 ）： 213 - 220 .

Si Y ， Liu J ， Shan W ， et al . Association of lymphocyte-to-monocyte ratio with total coronary plaque burden in patients with coronary artery disease [J ] . Coron Artery Dis ， 2020 ， 31 （ 7 ）： 650 - 655 .

吕秋菊，唐喜香，文哲瑶，等 . 外周血单核细胞表达PEDF在2型糖尿病视网膜病变中的意义 [J ] . 中山大学学报（医学科学版) ， 2015 ， 36 （ 1 ）： 114 - 119 .

Lü QJ ， Tang XX ， Wen ZY ， et al . Level of PEDF Increased in monocytes in diabetic retinopathy [J ] . J Journal of Sun Yat-sen University（Medical Sciences) ， 2015 ， 36 （ 1 ）： 114 - 119 .

Alavi A ， Sibbald R G ， Mayer D ， et al . Diabetic foot ulcers：part I. pathophysiology and prevention [J ] . J Am Acad Dermatol ， 2014 ， 70 （ 1 ）： 1.e1 - 1.e18 .

Moro-García MA ， Mayo JC ， Sainz RM ， et al . Influence of Inflammation in the Process of T Lymphocyte Differentiation：Proliferative，Metabolic，and Oxidative Changes [J ] . Front Immunol ， 2018 ， 9 ： 339 .

Top C ， Yildiz S ， Oncül O ， et al . Phagocytic activity of neutrophils improves over the course of therapy of diabetic foot infections [J ] . J Infect ， 2007 ， 55 （ 4 ）： 369 - 373 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Research status of GLP-1 receptor agonists in the treatment of obesity

Risk factors for aggravation of type 2 diabetic foot ulcer and features of bacterial infection

Risk factors for cognitive dysfunction in patients with brain infarction and type 2 diabetes

Study on serum free testosterone level and its relevant factors in adult male patients with type 2 diabetes mellitus

Related Author

Zhao Yacong

Wang Chen

Di Jianzhong

Mei Keqiang

Liu Zehui

Zhu Rong

Ma Lijuan

Han Rui

Related Institution

Department of Bariatric & Metabolic Surgery，Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Department of International Medicine，The First Affiliated Hospital of Kunming Medical University

Department of Geriatrics，Xijing Hospital，Air Force Medical University

Teaching Office of Health Statistics， Department of Military Preventive Medicine，Air Force Medical University

Department of Geriatrics， Tangdu Hospital，Air Force Medical University

⁰