Study on the diagnostic value of inflammation score system in preeclampsia

Cai Yu; Zhao Keyong

doi:10.13406/j.cnki.cyxb.003256

您当前的位置：

首页 >

文章列表页 >

Study on the diagnostic value of inflammation score system in preeclampsia

Clinical research | 更新时间：2025-10-21

- Study on the diagnostic value of inflammation score system in preeclampsia
- Journal of Chongqing Medical University Vol. 48, Issue 6, Pages: 712-714(2023)
- 作者机构：
  
  遵义医科大学第三附属医院/遵义市第一人民医院妇产科，遵义 563000
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.003256
  CLC： R714.2
- Received：08 September 2022，
  
  Revised：2023-03-10，
  
  Accepted：27 March 2023，
  
  Published：28 June 2023
- 稿件说明：
移动端阅览
蔡煜,赵科永.炎症评分系统对子痫前期诊断价值的研究[J].重庆医科大学学报,2023,48(6):712-714.

Cai Yu,Zhao Keyong.Study on the diagnostic value of inflammation score system in preeclampsia[J].Journal of Chongqing Medical University,2023,48(6):712-714.
蔡煜,赵科永.炎症评分系统对子痫前期诊断价值的研究[J].重庆医科大学学报,2023,48(6):712-714. DOI： 10.13406/j.cnki.cyxb.003256.

Cai Yu,Zhao Keyong.Study on the diagnostic value of inflammation score system in preeclampsia[J].Journal of Chongqing Medical University,2023,48(6):712-714. DOI： 10.13406/j.cnki.cyxb.003256.

摘要

目的

研究外周血中性粒细胞-淋巴细胞比值（neutrophil-lymphocyte ratio，NLR）、血小板-淋巴细胞比值（platelet-lymphocyte ratio，PLR）、平均血小板体积（mean platelet volume，MPV）和血小板压积（platelet hematocrit，PCT）在子痫前期孕妇中的变化及临床意义。

方法

回顾性研究160例子痫前期孕妇的外周血常规数据及临床资料。其中，160例子痫前期孕妇包含轻度子痫前期孕妇（mild preeclampsia，MPE）80例、重度子痫前期孕妇（severe preeclampsia，SPE）80例。对照组为同期就诊的80例正常孕妇（normal pregnancy，NP）。比较SPE、MPE和对照组之间NLR、PLR、MPV和PCT。

结果

3组中性粒细胞、PLR、MPV、PCT比较差异有统计学意义（

0.05），淋巴细胞差异无统计学意义（

0.05）。MPE组与对照组比较，中性粒细胞差异有统计学意义（

0.05）。SPE 组与NP组相比，中性粒细胞、血小板、PLR、MPV、PCT差异有统计学意义（

0.05），SPE组与MPE组比较，中性粒细胞、血小板、PLR、MPV和PCT 差异有统计学意义（

0.05）。

结论

外周血中PLR、MPV和PCT检测用于子痫前期的诊断具有一定价值，同时可以反映子痫前期的严重程度。

Abstract

Objective

To study the changes and clinical significance of neutrophil-lymphocyte ratio（NLR），platelet-lymphocyte ratio （PLR） in peripheral blood，mean platelet volume（MPV） and platelet hematocrit（PCT） in preeclampsia.

Methods

The peripheral blood routine data and clinical data of 160 pregnant women with preeclampsia were retrospectively studied，including 80 cases of mild preeclampsia（MPE） and 80 cases of severe preeclampsia（SPE）. The control group included 80 normal pregnant women visited our department during the same period. The NLR，PLR，MPV，and PCT were compared among SPE，MPE and the control group.

Results

There were significant differences in neutrophil，PLR，MPV，PCT among the three groups（

0.05），but no significant difference in lymphocyte（

0.05）. There was significant difference in neutrophils between the MPE group and the control group（

0.05）. There were significant differences in neutrophil，platelet，PLR，MPV and PCT between SPE group and control group（

0.05），and there were significant differences in neutrophil，platelet，PLR，MPV and PCT between SPE group and MPE group（

0.05）.

Conclusion

The detection of PLR，MPV and PCT in peripheral blood has certain value in the diagnosis of preeclampsia，and it can also reflect the severity of preeclampsia.

关键词

Keywords

references

Yıldız GA ， Yılmaz EPT . The association between protein levels in 24-hour urine samples and maternal and neonatal outcomes of pregnant women with preeclampsia [J ] . J Turk Ger Gynecol Assoc ， 2022 ， 23 （ 3 ）： 190 - 198 .

Li YY ， Cao J ， Li JL ， et al . Screening high-risk population of persistent postpartum hypertension in women with preeclampsia using latent class cluster analysis [J ] . BMC Pregnancy Childbirth ， 2022 ， 22 （ 1 ）： 687 .

Beernink RHJ ， Zwertbroek EF ， Schuitemaker JHN ， et al . First trimester serum biomarker discovery study for early onset，preterm onset and preeclampsia at term [J ] . Placenta ， 2022 ， 128 ： 39 - 48 .

Carter SA ， Lin JC ， Chow T ， et al . Maternal obesity，diabetes，preeclampsia，and asthma during pregnancy and likelihood of autism spectrum disorder with gastrointestinal disturbances in offspring [J ] . Autism ， 2022 ， 2022 ： 13623613221118430 .

Vaisbuch E ， Romero R ， Mazaki-Tovi S ， et al . Retinol binding protein 4：a novel association with early-onset preeclampsia [J ] . J Perinat Med ， 2010 ， 38 （ 2 ）： 129 - 139 .

Ding YZ ， Yang XF ， Han XX ， et al . Ferroptosis-related gene expression in the pathogenesis of preeclampsia [J ] . Front Genet ， 2022 ， 13 ： 927869 .

MacKay CR ， Marques FZ . Dysbiosis in preeclampsia and treatment with short chain fatty acids [J ] . Circ Res ， 2022 ， 131 （ 6 ）： 507 - 509 .

Wang H ， Liu ML ， Chu C ， et al . Paeonol alleviates placental inflammation and apoptosis in preeclampsia by inhibiting the JAK2/STAT3 signaling pathway [J ] . Kaohsiung J Med Sci ， 2022 ， 38 （ 11 ）： 1103 - 1112 .

Rezk M ， Grasegger L ， Brandstetter N ， et al . Biomarker screening in preeclampsia：an RNA-sequencing approach based on data from multiple studies [J ] . J Hypertens ， 2022 ， 40 （ 10 ）： 2022 - 2036 .

Li M ， Yue CY . Abnormal uterine artery Doppler ultrasound during gestational 21-23 weeks associated with pre-eclampsia [J ] . Int J Gynaecol Obstet ， 2023 ， 161 （ 1 ）： 264 - 270 .

Yousefzadeh Y ， Soltani-Zangbar MS ， Kalafi L ， et al . Evaluation of CD39，CD73，HIF-1α，and their related miRNAs expression in decidua of preeclampsia cases compared to healthy pregnant women [J ] . Mol Biol Rep ， 2022 ， 49 （ 11 ）： 10183 - 10193 .

Sadeghi Afkham M ， Hashemnejad M ， Esmaelzadeh Saeieh S ， et al . Prophylactic effect of rectal and sublingual misoprostol on postpartum hemorrhage in mothers with preeclampsia following cesarean section surgery；a double-blind randomized controlled trial [J ] . Ann Med Surg（Lond）， 2022 ， 80 ： 104175 .

Li JY ， Hou L ， Zhao R ， et al . Potential use of anti-cancer drugs for treatment of preeclampsia by targeting the miRNA-IGF1R-PI3K-Akt axis [J ] . Evid Based Complement Alternat Med ， 2022 ， 2022 ： 3883082 .

Priya V ， Amanda H ， Craig Maria E ， et al . A review of infant growth and psychomotor developmental outcomes after intrauterine exposure to preeclampsia [J ] . BMC Pediatr ， 2022 ， 22 （ 1 ）： 513 .

Burgess A ， Dalke K ， Wheeling J ， et al . Standardizing screening for preeclampsia risk factors to improve prescribing of low-dose aspirin [J ] . J Healthc Qual ， 2022 ， 44 （ 6 ）： 324 - 330 .

Reeder HT ， Haneuse S ， Modest AM ， et al . A novel approach to joint prediction of preeclampsia and delivery timing using semicompeting risks [J ] . Am J Obstet Gynecol ， 2023 ， 228 （ 3 ）： 338. e1 - 338 . e12.

Dierickx I ， Kremer C ， Bruckers L ， et al . Early-onset preeclampsia is characterised by an increased vascular tone in internal jugular veins [J ] . Front Cardiovasc Med ， 2022 ， 9 ： 911059 .

Liu MY ， Yang XF ， Chen GL ， et al . Development of a prediction model on preeclampsia using machine learning-based method：a retrospective cohort study in China [J ] . Front Physiol ， 2022 ， 13 ： 896969 .

Veiga ECA ， Korkes HA ， Salomão KB ， et al . Association of LEPTIN and other inflammatory markers with preeclampsia：a systematic review [J ] . Front Pharmacol ， 2022 ， 13 ： 966400 .

Mashak B ， Bagheri RB ， Noorani G ， et al . Comparison of hemodynamic and biochemical factors and pregnancy complications in women with/without preeclampsia [J ] . Maedica（Bucur）， 2022 ， 17 （ 2 ）： 363 - 370 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Lactate dehydrogenase: a potential regulatory molecule in preeclampsia

Application value of placental growth factor，soluble fms-like tyrosine kinase-1，and glycosylated fibronectin in the prediction of preeclampsia

Expression of activated Cdc42-associated kinase in the placenta of pregnant women with preeclampsia and its regulatory effect on invasion of trophoblasts

Effect of GPR30 protein on function of trophoblast cells and its relationship with the development of preeclampsia

Related Author

Gu Weirong

Zhang Xiaoyue

Pei Jiangnan

Liu Zhenzhen

Xiao Jianping

Shi Hao

Su Jingna

Zhao Di

Related Institution

Department of Obstetrics，Obstetrics & Gynecology Hospital of Fudan University

Department of Medical Genetics and Prenatal Diagnosis，Wuxi Maternal and Child Health Hospital

Department of Obstetrics and Gynecology，The First Affiliated Hospital of Chongqing Medical University

Department of Obstetrics，People’s Hospital of Chongqing Hechuan

Department of Obstetrics and Gynecology,The First Affiliated Hospital of Chongqing Medical University

⁰