1.天津中医药大学中西医结合学院,天津 301617
2.天津中德应用技术大学科技处,天津 300350
Received:16 October 2022,
Revised:2023-04-03,
Accepted:13 April 2023,
Published:28 May 2023
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李涛,于志超,赵静雯,等.铁死亡在阿尔茨海默病中的研究进展[J].重庆医科大学学报,2023,48(5):508-511.
Li Tao,Yu Zhichao,Zhao Jingwen,et al.Research advances of ferroptosis in Alzheimer's disease[J].Journal of Chongqing Medical University,2023,48(5):508-511.
李涛,于志超,赵静雯,等.铁死亡在阿尔茨海默病中的研究进展[J].重庆医科大学学报,2023,48(5):508-511. DOI: 10.13406/j.cnki.cyxb.003222.
Li Tao,Yu Zhichao,Zhao Jingwen,et al.Research advances of ferroptosis in Alzheimer's disease[J].Journal of Chongqing Medical University,2023,48(5):508-511. DOI: 10.13406/j.cnki.cyxb.003222.
最新研究表明,铁死亡在阿尔茨海默病(Alzheimer's disease,AD)的发生发展中扮演重要角色。本文通过对近年相关国内外文献进行总结,对铁代谢紊乱、谷胱甘肽耗竭和脂质过氧化三种铁死亡主要机制与AD的关系进行分类综述,以期为AD的机制研究提供参考并提示铁死亡有望成为治疗AD的新策略。
Recent studies have shown that ferroptosis plays an important role in the occurrence and development of Alzheimer's disease. This article summarizes relevant domestic and foreign literature in recent years,and categorizes and reviews the relationship between the three main mechanisms of ferroptosis,namely iron metabolism disorder,glutathione(GSH) depletion,and lipid peroxidation,and AD. This finding suggests that ferroptosis may become a new therapeutic strategy to treat and prevent AD in the future.
Dixon SJ , Lemberg KM , Lamprecht MR , et al . Ferroptosis:an iron-dependent form of nonapoptotic cell death [J ] . Cell , 2012 , 149 ( 5 ): 1060 - 1072 .
Yu HT , Guo PY , Xie XZ , et al . Ferroptosis,a new form of cell death,and its relationships with tumourous diseases [J ] . J Cell Mol Med , 2017 , 21 ( 4 ): 648 - 657 .
Li J , Cao F , Yin HL , et al . Ferroptosis:past,present and future [J ] . Cell Death Dis , 2020 , 11 ( 2 ): 88 .
Pleen J , Townley R . Alzheimer's disease clinical trial update 2019-2021 [J ] . J Neurol , 2022 , 269 ( 2 ): 1038 - 1051 .
Trejo-Lopez JA , Yachnis AT , Prokop S . Neuropathology of Alzheimer's disease [J ] . Neurotherapeutics , 2022 , 19 ( 1 ): 173 - 185 .
Ma C , Hong FF , Yang SL . Amyloidosis in Alzheimer's disease:pathogeny,etiology,and related therapeutic directions [J ] . Molecules , 2022 , 27 ( 4 ): 1210 .
Yan N , Zhang JJ . The emerging roles of ferroptosis in vascular cognitive impairment [J ] . Front Neurosci , 2019 , 13 : 811 .
Chen K , Jiang XB , Wu MX , et al . Ferroptosis,a potential therapeutic target in Alzheimer's disease [J ] . Front Cell Dev Biol , 2021 , 9 : 704298 .
Wu J , Yang JJ , Cao Y , et al . Iron overload contributes to general anaesthesia-induced neurotoxicity and cognitive deficits [J ] . J Neuroinflammation , 2020 , 17 ( 1 ): 110 .
Gao MH , Monian P , Jiang XJ . Metabolism and iron signaling in ferroptotic cell death [J ] . Oncotarget , 2015 , 6 ( 34 ): 35145 - 35146 .
Lane DJR , Metselaar B , Greenough M , et al . Ferroptosis and NRF2:an emerging battlefield in the neurodegeneration of Alzheimer's disease [J ] . Essays Biochem , 2021 , 65 ( 7 ): 925 - 940 .
Hayano M , Yang WS , Corn CK , et al . Loss of cysteinyl-tRNA synthetase(CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation [J ] . Cell Death Differ , 2016 , 23 ( 2 ): 270 - 278 .
Zheng JS , Conrad M . The metabolic underpinnings of ferroptosis [J ] . Cell Metab , 2020 , 32 ( 6 ): 920 - 937 .
Riegman M , Sagie L , Galed C , et al . Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture [J ] . Nat Cell Biol , 2020 , 22 ( 9 ): 1042 - 1048 .
Liang DG , Minikes AM , Jiang XJ . Ferroptosis at the intersection of lipid metabolism and cellular signaling [J ] . Mol Cell , 2022 , 82 ( 12 ): 2215 - 2227 .
Ratan RR . The chemical biology of ferroptosis in the central nervous system [J ] . Cell Chem Biol , 2020 , 27 ( 5 ): 479 - 498 .
Hambright WS , Fonseca RS , Chen LJ , et al . Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration [J ] . Redox Biol , 2017 , 12 : 8 - 17 .
Huang L , McClatchy DB , Maher P , et al . Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death [J ] . Cell Death Dis , 2020 , 11 ( 10 ): 828 .
Fischer W , Currais A , Liang ZB , et al . Old age-associated phenotypic screening for Alzheimer's disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santa [J ] . Redox Biol , 2019 , 21 : 101089 .
Zhang YH , Wang DW , Xu SF , et al . α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress,inflammation,ferroptosis,and tauopathy in P301S Tau transgenic mice [J ] . Redox Biol , 2018 , 14 : 535 - 548 .
Fakhri S , Pesce M , Patruno A , et al . Attenuation of Nrf2/Keap1/ARE in Alzheimer's disease by plant secondary metabolites:a mechanistic review [J ] . Molecules , 2020 , 25 ( 21 ): 4926 .
Li L , Li WJ , Zheng XR , et al . Eriodictyol ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via vitamin D receptor-mediated Nrf2 activation [J ] . Mol Med , 2022 , 28 ( 1 ): 11 .
Yang SX , Xie ZP , Pei TT , et al . Salidroside attenuates neuronal ferroptosis by activating the Nrf2/HO1 signaling pathway in Aβ 1-42 -induced Alzheimer's disease mice and glutamate-injured HT22 cells [J ] . Chin Med , 2022 , 17 ( 1 ): 82 .
Cheng LT , Liang RF , Li Z , et al . Aluminum maltolate triggers ferroptosis in neurons:mechanism of action [J ] . Toxicol Mech Methods , 2021 , 31 ( 1 ): 33 - 42 .
Long HZ , Cheng Y , Zhou ZW , et al . The key roles of organelles and ferroptosis in Alzheimer's disease [J ] . J Neurosci Res , 2022 , 100 ( 6 ): 1257 - 1280 .
Bao WD , Pang P , Zhou XT , et al . Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer's disease [J ] . Cell Death Differ , 2021 , 28 ( 5 ): 1548 - 1562 .
Schröder N , Figueiredo LS , de Lima MNM . Role of brain iron accumulation in cognitive dysfunction:evidence from animal models and human studies [J ] . J Alzheimer's Dis , 2013 , 34 ( 4 ): 797 - 812 .
Derry PJ , Hegde ML , Jackson GR , et al . Revisiting the intersection of amyloid,pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective [J ] . Prog Neurobiol , 2020 , 184 : 101716 .
Gong NJ , Dibb R , Bulk M , et al . Imaging beta amyloid aggregation and iron accumulation in Alzheimer's disease using quantitative susceptibility mapping MRI [J ] . Neuroimage , 2019 , 191 : 176 - 185 .
Yan N , Zhang JJ . Iron metabolism,ferroptosis,and the links with Alzheimer's disease [J ] . Front Neurosci , 2020 , 13 : 1443 .
Nikseresht S , Bush AI , Ayton S . Treating Alzheimer's disease by targeting iron [J ] . Br J Pharmacol , 2019 , 176 ( 18 ): 3622 - 3635 .
Rao SS , Lago L , Gonzalez de Vega R , et al . Characterising the spatial and temporal brain metal profile in a mouse model of tauopathy [J ] . Metallomics , 2020 , 12 ( 2 ): 301 - 313 .
Plascencia-Villa G , Perry G . Preventive and therapeutic strategies in Alzheimer's disease:focus on oxidative stress,redox metals,and ferroptosis [J ] . Antioxid Redox Signal , 2021 , 34 ( 8 ): 591 - 610 .
Tan QY , Fang YY , Gu Q . Mechanisms of modulation of ferroptosis and its role in central nervous system diseases [J ] . Front Pharmacol , 2021 , 12 : 657033 .
Li Y , Zhang ED , Yang H , et al . Gastrodin ameliorates cognitive dysfunction in vascular dementia rats by suppressing ferroptosis via the regulation of the Nrf2/Keap1-GPx4 signaling pathway [J ] . Molecules , 2022 , 27 ( 19 ): 6311 .
Ansari MA , Scheff SW . Oxidative stress in the progression of Alzheimer disease in the frontal cortex [J ] . J Neuropathol Exp Neurol , 2010 , 69 ( 2 ): 155 - 167 .
Greenough MA , Lane DJR , Balez R , et al . Selective ferroptosis vulnerability due to familial Alzheimer's disease presenilin mutations [J ] . Cell Death Differ , 2022 , 29 ( 11 ): 2123 - 2136 .
Nebie O , Devos D , Vingtdeux V , et al . The neuroprotective activity of heat-treated human platelet lysate biomaterials manufactured from outdated pathogen-reduced(amotosalen/UVA) platelet concentrates [J ] . J Biomed Sci , 2019 , 26 ( 1 ): 89 .
Wang CY , Chen SS , Guo HY , et al . Forsythoside A mitigates alzheimer's-like pathology by inhibiting ferroptosis-mediated neuroinflammation via Nrf2/GPX4 axis activation [J ] . Int J Biol Sci , 2022 , 18 ( 5 ): 2075 - 2090 .
Gao Y , Li JT , Wu QL , et al . Tetrahydroxy stilbene glycoside ameliorates Alzheimer's disease in APP/PS1 mice via glutathione peroxidase related ferroptosis [J ] . Int Immunopharmacol , 2021 , 99 : 108002 .
Shao L , Dong C , Geng DQ , et al . Ginkgolide B protects against cognitive impairment in senescence-accelerated P8 mice by mitigating oxidative stress,inflammation and ferroptosis [J ] . Biochem Biophys Res Commun , 2021 , 572 : 7 - 14 .
Ferré-González L , Peña-Bautista C , Baquero M , et al . Assessment of lipid peroxidation in Alzheimer's disease differential diagnosis and prognosis [J ] . Antioxidants , 2022 , 11 ( 3 ): 551 .
Vitalakumar D , Sharma A , Flora SJS . Ferroptosis:a potential therapeutic target for neurodegenerative diseases [J ] . J Biochem Mol Toxicol , 2021 , 35 ( 8 ): e22830 .
Butterfield DA . Brain lipid peroxidation and alzheimer disease:synergy between the butterfield and mattson laboratories [J ] . Ageing Res Rev , 2020 , 64 : 101049 .
Park MW , Cha HW , Kim J , et al . NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases [J ] . Redox Biol , 2021 , 41 : 101947 .
Ates G , Goldberg J , Currais A , et al . CMS121,a fatty acid synthase inhibitor,protects against excess lipid peroxidation and inflammation and alleviates cognitive loss in a transgenic mouse model of Alzheimer's disease [J ] . Redox Biol , 2020 , 36 : 101648 .
Di Meco A , Li JG , Blass BE , et al . 12/15-lipoxygenase inhibition reverses cognitive impairment,brain amyloidosis,and tau pathology by stimulating autophagy in aged triple transgenic mice [J ] . Biol Psychiatry , 2017 , 81 ( 2 ): 92 - 100 .
Southon A , Szostak K , Acevedo KM , et al . Cu II (ATSM) inhibits ferroptosis:implications for treatment of neurodegenerative disease [J ] . Br J Pharmacol , 2020 , 177 ( 3 ): 656 - 667 .
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