Nest case-control study of the correlation between changes in peripheral blood inflammatory cells and electrolyte levels and prognosis of hand-foot-mouth disease in Zhengzhou from 2015 to 2019

Zheng Shan; Feng Huifen; Xu Jing; Feng Shuang; Yang Jing

doi:10.13406/j.cnki.cyxb.003192

您当前的位置：

首页 >

文章列表页 >

Nest case-control study of the correlation between changes in peripheral blood inflammatory cells and electrolyte levels and prognosis of hand-foot-mouth disease in Zhengzhou from 2015 to 2019

Clinical research | 更新时间：2025-10-21

- Nest case-control study of the correlation between changes in peripheral blood inflammatory cells and electrolyte levels and prognosis of hand-foot-mouth disease in Zhengzhou from 2015 to 2019
- Journal of Chongqing Medical University Vol. 48, Issue 3, Pages: 304-309(2023)
- 作者机构：
  
  1.郑州大学第五附属医院，消化内科，郑州 450052
  2.郑州大学第五附属医院，感染科，郑州 450052
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.003192
  CLC： R512.5
- Received：27 September 2022，
  
  Revised：2022-12-23，
  
  Accepted：03 January 2023，
  
  Published：28 March 2023
- 稿件说明：
移动端阅览
郑珊,冯慧芬,徐晶,等.郑州市2015年至2019年手足口病患者外周血炎症细胞和电解质水平变化与预后关联的巢式病例对照研究[J].重庆医科大学学报,2023,48(3):304-309.

Zheng Shan,Feng Huifen,Xu Jing,et al.Nest case-control study of the correlation between changes in peripheral blood inflammatory cells and electrolyte levels and prognosis of hand-foot-mouth disease in Zhengzhou from 2015 to 2019[J].Journal of Chongqing Medical University,2023,48(3):304-309.
郑珊,冯慧芬,徐晶,等.郑州市2015年至2019年手足口病患者外周血炎症细胞和电解质水平变化与预后关联的巢式病例对照研究[J].重庆医科大学学报,2023,48(3):304-309. DOI： 10.13406/j.cnki.cyxb.003192.

Zheng Shan,Feng Huifen,Xu Jing,et al.Nest case-control study of the correlation between changes in peripheral blood inflammatory cells and electrolyte levels and prognosis of hand-foot-mouth disease in Zhengzhou from 2015 to 2019[J].Journal of Chongqing Medical University,2023,48(3):304-309. DOI： 10.13406/j.cnki.cyxb.003192.

摘要

目的

探讨血清炎症细胞和电解质水平变化与手足口病（hand-foot-mouth disease，HFMD）严重程度相关性。

方法

采用巢式病例对照研究，选取2015年至2019年于河南省儿童医院住院的HFMD患儿为研究对象，绘制趋势图进行对比，并构建logistic回归模型预测手足口病重症化的危险因素。

结果

logistic回归多因素分析中炎症细胞（白细胞、中性粒细胞比率、血小板计数）增加在轻、重症HFMD病程第1~3天差异有统计学意义（

0.05）；电解质水平

改变（K

升高、Ca

和Na

降低）在轻、重症HFMD病程第2~5天差异有统计学意义（

0.05）；重症HFMD组中居住地为农村、高热的比率明显高于普通HFMD组（

0.05）。

结论

炎症细胞（白细胞、中性粒细胞比率、血小板计数）增加和电解质水平改变（K

升高、Ca

和Na

降低）可提示重症HFMD不同病程的进展，监测HFMD患者病程中外周血炎症细胞和电解质水平变化具有一定的临床价值，应加强对居住地为农村和高热HFMD患者的健康管理。

Abstract

Objective

To explore the correlation between serum inflammatory cells and electrolyte levels and the severity of hand-foot-mouth disease（HFMD）.

Methods

Using the Nest case-control study，we selected children hospitalized in Henan Children's Hospital from 2015 to 2019 as research objects， mapped a trend chart for comparison， and built a logistic regression model to predict the risk factors of severe HFMD.

Results

Multivariate logistic regression analysis showed that the increase of inflammatory cells（leukocyte， neutrophil ratio，platelet count） in the course of mild and severe HFMD（day 1 to day 3） was statistically significant（

0.05）. The changes of electrolyte levels（increased K

，decreased Ca

and Na

） in the course of mild and severe HFMD（day 2 to day 5） was statistically significant（

0.05）. The rate of high fever in severe HFMD group was significantly higher than that in common HFMD group（

0.05）.

Conclusion

The increase of inflammatory cells（leukocyte， neutrophil ratio and platelet count） and the change of electrolyte levels（K

increase，Ca

and Na

decrease） can indicate the progression of severe HFMD. Monitoring the changes of inflammatory cells and electrolyte levels in peripheral blood of patients with HFMD during the course of the disease has certain clinical value. Health management of HFMD patients with high fever who live in rural are

as should be strengthened.

关键词

Keywords

references

He FL ， Rui J ， Deng ZQ ， et al . Surveillance，epidemiology and impact of EV-A71 vaccination on hand，foot，and mouth disease in Nanchang，China，2010-2019 [J ] . Front Microbiol ， 2022 ， 12 ： 811553 .

Fong SY ， Mori D ， Rundi C ， et al . A five-year retrospective study on the epidemiology of hand，foot and mouth disease in Sabah，Malaysia [J ] . Sci Rep ， 2021 ， 11 （ 1 ）： 17814 .

Miao L ， Liu YJ ， Luo PL ， et al . Association between platelet count and the risk and progression of hand，foot，and mouth disease among children [J ] . Clinics ， 2020 ， 75 ： e1619 .

Zhu HW ， Xu R ， Zang HH ， et al . Metabolomic characteristics of hand-foot-mouth disease facilitate discovery and diagnosis of pathogeny [J ] . Pediatr Int ， 2022 ， 64 （ 1 ）： e14927 .

Li YP ， Wang MQ ， Wang WJ ， et al . Prognostic value of neutrophil-to-lymphocyte ratio in predicting death risk in patients with severe hand，foot and mouth disease [J ] . Ther Clin Risk Manag ， 2020 ， 16 ： 1023 - 1029 .

Du ZC ， Yang BY ， Jalaludin B ， et al . Association of neighborhood greenness with severity of hand，foot，and mouth disease [J ] . BMC Public Health ， 2022 ， 22 （ 1 ）： 38 .

Li YN ， Xiong TT ， Meng Y ， et al . Risk factors for severe hand，foot，and mouth disease infected with Coxsackievirus A6：a hospital-based case-control study [J ] . J Med Virol ， 2020 ， 92 （ 12 ）： 3144 - 3150 .

Wang ZC ， Liu T ， Li JM ， et al . Risk factors for hand，foot，and mouth disease caused by coxsackievirus A6 in children under 6 years of age in Tianjin，China：a case-control study [J ] . Jpn J Infect Dis ， 2021 ， 74 （ 5 ）： 437 - 442 .

中华人民共和国卫生部 . 手足口病诊疗指南（2010年版） [J ] . 国际呼吸杂志， 2010 ， 30 （ 24 ）： 1473 - 1475 .

Ministry of Health of The People's Republic of China . Diagnosis and treatment guideline on hand-foot-mouth disease（2010） [J ] . Int J Respir ， 2010 ， 30 （ 24 ）： 1473 - 1475 .

Huang L ， Wang T ， Liu XX ， et al . Spatial-temporal-demographic and virological changes of hand，foot and mouth disease incidence after vaccination in a vulnerable region of China [J ] . BMC Public Health ， 2022 ， 22 （ 1 ）： 1468 .

王小莉，魏洪鑫，贾　蕾，等 . 我国手足口病经济负担研究概况 [J ] . 中华流行病学杂志， 2020 ， 41 （ 2 ）： 273 - 279 .

Wang XL ， Wei HX ， Jia L ， et al . Summary of research in economic burden of hand，foot，and mouth disease in China [J ] . Chin J Epidemiol ， 2020 ， 41 （ 2 ）： 273 - 279 .

Shang WZ ， Qian SY ， Fang LJ ， et al . Association study of inflammatory cytokine and chemokine expression in hand foot and mouth disease [J ] . Oncotarget ， 2017 ， 8 （ 45 ）： 79425 - 79432 .

Shao P ， Wu XX ， Li HB ， et al . Clinical significance of inflammatory cytokine and chemokine expression in hand，foot and mouth disease [J ] . Mol Med Rep ， 2017 ， 15 （ 5 ）： 2859 - 2866 .

Qin LW ， Dang DJ ， Wang XH ， et al . Identification of immune and metabolic predictors of severe hand-foot-mouth disease [J ] . PLoS One ， 2019 ， 14 （ 5 ）： e0216993 .

Li PQ ， Huang YG ， Zhu DP ， et al . Risk factors for severe hand-foot-mouth disease in China：a systematic review and Meta-analysis [J ] . Front Pediatr ， 2021 ， 9 ： 716039 .

Sun JF ， Li HL ， Sun BX . Correlation analysis on serum inflammatory cytokine level and neurogenic pulmonary edema for children with severe hand-foot-mouth disease [J ] . Eur J Med Res ， 2018 ， 23 （ 1 ）： 21 .

Aitken EH ， Alemu A ， Rogerson SJ . Neutrophils and malaria [J ] . Front Immunol ， 2018 ， 9 ： 3005 .

Yi ZJ ， Pei SJ ， Suo WS ， et al . Epidemiological characteristics，routine laboratory diagnosis，clinical signs and risk factors for hand，-foot-and-mouth disease：a systematic review and Meta-analysis [J ] . PLoS One ， 2022 ， 17 （ 4 ）： e0267716 .

Wang YR ， Wu MD ， Li YC ， et al . The effects of SARS-CoV-2 infection on modulating innate immunity and strategies of combating inflammatory response for COVID-19 therapy [J ] . J Biomed Sci ， 2022 ， 29 （ 1 ）： 27 .

Ponomarev ED . Fresh evidence for platelets as neuronal and innate immune cells：their role in the activation，differentiation，and deactivation of Th1，Th17，and tregs during tissue inflammation [J ] . Front Immunol ， 2018 ， 9 ： 406 .

Li QW ， Wang YM ， Xue WY ， et al . Immunomodulatory effects of platelets on the severity of hand，foot，and mouth disease infected with enterovirus 71 [J ] . Pediatr Res ， 2021 ， 89 （ 4 ）： 814 - 822 .

Elia E ， Montecucco F ， Portincasa P ， et al . Update on pathological platelet activation in coronary thrombosis [J ] . J Cell Physiol ， 2019 ， 234 （ 3 ）： 2121 - 2133 .

Jin YF ， Li D ， Sun TT ， et al . Pathological features of Enterovirus 71-associated brain and lung damage in mice based on quantitative proteomic analysis [J ] . Front Microbiol ， 2021 ， 12 ： 663019 .

Pearce D ， Manis AD ， Nesterov V ， et al . Regulation of distal tubule sodium transport：mechanisms and roles in homeostasis and pathophysiology [J ] . Pflugers Arch - Eur J Physiol ， 2022 ， 474 （ 8 ）： 869 - 884 .

苍　旻，谢国锦，李松涛，等 . 血清维生素D与重症手足口病患儿临床表现的关系 [J ] . 南京医科大学学报（自然科学版）， 2019 ， 39 （ 9 ）： 1341 - 1344，1360 .

Cang M ， Xie GJ ， Li ST ， et al . The relationship between serum 25-hydroxyvitamin D and clinical manifestations in severe hand-foot-and-mouth disease [J ] . J Nanjing Med Univ Nat Sci ， 2019 ， 39 （ 9 ）： 1341 - 1344，1360 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The clinical features of hand-foot-mouth disease complicated with nervous system damage and the analysis for its risk factors

MRI characteristics and pathogenesis of brainstem encephalitis in the enterovirus type 71 infected hand-foot-mouth disease

Investigation on reference intervals of serum K+，Na+，Cl-，TCa，TCO2，FBG and CRP by dry chemical system among preschool children in Shenzhen

Related Author

ZHOU Da-ming

et al

宗文宏

姜继军

黄祖璇

CHEN Feng1

LI Jian-jun1

LIU Tao2

Related Institution

Department of Infectious Diseases,the People’s Hospital of Taizhou,Nantong Medical College

Department of Radiology

Department of Neurology

Department of Pediatrics,Hainan Provincial People’s Hospital

Department of Clinical Laboratory，Shenzhen Children’s Hospital

⁰